Effects of ions traces on the dissolution of bioceramics composed of hydroxyapatite and Î²-tricalcium phosphate

Jamil, M.; Abida, Fatima; Hatim, Z.; Mostafa, Ehab; Gourri, E.

doi:10.13171/mjc.4.1.2015.14.03.14.15/jamil

Cited by 2 publications

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“…Substituted HAPs, specifically HAPc-5%Sr and HAPc-10%Sr, release higher amounts of calcium ions ( figure 4 a ) and phosphate ions ( figure 4 g ) than pure non-calcined HAP, namely the solubility of HAPs is increased by substitution in the HAP lattice. The higher solubility of substituted HAPs when compared with pure HAP is known in the literature [ 10 , 34 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…By substitution of some Ca 2+ ions by other cations, and/or of phosphate and hydroxide ions by silicate or carbonate ions, (but not by fluoride ions), the solubility of substituted HAP is generally increased [ 10 , 34 , 38 , 39 ]. For instance, an increase in the solubility of Sr-substituted HAP with increasing strontium content was observed [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study

et al. 2021

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Multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration owing to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopaedic and dental applications. In this study, nano-hydroxyapatite (HAP) substituted with multiple cations (Sr 2+ , Mg 2+ and Zn 2+ ) for Ca 2+ and anion ( Si O 4 4 − ) for P O 4 3 − and OH − , specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is HAP-1.5%Mg–0.2%Zn–0.2%Si), both lyophilized non-calcined and lyophilized calcined, were evaluated for their in vitro ions release. These nanomaterials were characterized by scanning electron microscopy, field emission-scanning electron microscopy and energy-dispersive X-ray, as well as by atomic force microscope images and by surface specific areas and porosity. Further, the release of cations and of phosphate anions were assessed from nano-HAP and ms-HAPs, both in water and in simulated body fluid, in static and simulated dynamic conditions, using inductively coupled plasma optical emission spectrometry. The release profiles were analysed and the influence of experimental conditions was determined for each of the six nanomaterials and for various periods of time. The pH of the samples soaked in the immersion liquids was also measured. The ion release mechanism was theoretically investigated using the Korsmeyer–Peppas model. The results indicated a mechanism principally based on diffusion and dissolution, with possible contribution of ion exchange. The surface of ms-HAP nanoparticles is more susceptible to dissolution into immersion liquids owing to the lattice strain provoked by simultaneous multi-substitution in HAP structure. According to the findings, it is rational to suggest that both materials HAPc-5%Sr and HAPc-10%Sr are bioactive and can be potential candidates in bone tissue regeneration.

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Section: Resultsmentioning

confidence: 99%