Effects of Iron Nanoparticles on Immune Response of Two Immunocytes Like Virus

Zhang, Ling; Chen, Yan; Lin, Weihong; Liu, Yingxun; Wang, Jinke

doi:10.1166/nnl.2017.2539

Cited by 3 publications

(9 citation statements)

References 47 publications

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“…18 Our results are consistent with the previous studies. 19 Our previous studies also show these related genes ( Mmp9 , Icam1 , Icam2 , Itgav , Csf3 , and Itgb7 ) of RAW264.7 cells overexpression after FeNPs treatment. 19,52…”

Section: Discussionmentioning

confidence: 74%

“…Fcgri and Fcgr3 as FcγR were also differently expressed in the RAW264.7 cells in our previous studies. 19,43…”

Section: Discussionmentioning

confidence: 99%

“…Tlr4 and Tlr7 are both upregulated as typical immune pathways receptors in addition to Ddx58 , Ifih1 , Nlrp10 , Nlrp3 , Zbp1 , and Clec4n/ 4e. 19 , 43,52 FeNPs trigger to product many kinds of cytokines, including IL-1β, TNF, LTB, many C-X-C and C-C motif chemokine ligands. 19 These results indicate that FeNPs might also activate RAW264.7 cells to M1 phenotypes and then attack Hepa1-6 cells.…”

Section: Discussionmentioning

confidence: 99%

“…18 Our previous studies demonstrate that an iron oxide nanoparticles coated by DMSA (named FeNPs) triggered comprehensive immune responses of mouse macrophages (RAW264.7 cells), inducing some typical immune pathways, such as retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), toll-like receptors (TLRs), and nucleotide oligomerization domain (NOD)-like receptors (NLRs) signal pathways. 19 FeNPs also trigger production of many kinds of cytokines. 19 The results indicate a potential application of FeNPs in cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…19 FeNPs also trigger production of many kinds of cytokines. 19 The results indicate a potential application of FeNPs in cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

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In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages

et al. 2019

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Macrophages as immunocyte are attracting more and more attention in cancer therapy. Our previous study observed that dimercaptosuccinic acid (DMSA)-coated Fe3O4 magnetic nanoparticles triggered comprehensive immune responses of mouse macrophages (RAW264.7 cells) and induced production of many kinds of cytokines. This study investigated the effects of Fe3O4 magnetic nanoparticles on RAW264.7 cells proliferation, migration, and inhibition of tumor growth in vitro. Fe3O4 magnetic nanoparticles had an average size of about 11 nm with good dispersibility and uniformity. Fe3O4 magnetic nanoparticles internalized efficiently into RAW264.7 cells. Through Cell Counting Kit-8 (CCK-8) detection, the proliferation of RAW264.7 cells significantly increased by the low-dose Fe3O4 magnetic nanoparticles (50 µg/mL) treatment. The results of wound-healing and Transwell assays both displayed a significant promotion of the RAW264.7 cells migratory capability compared with control group ( P<0.01). It is interesting to find that a large number of proliferated RAW264.7 cells were activated to surround quickly and attack mouse liver cancer cell (Hepa1-6) cells by Fe3O4 magnetic nanoparticles. The growth of Hepa1-6 cells was effectively inhibited according to microscope imaging and flow cytometry analysis. The inhibition may be cooperative effects of RAW264.7 cells proliferation, migration, and immune activation. The results suggest potential clinical value of low-dose iron oxide nanomaterials in cancer therapy.

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Section: Discussionmentioning

confidence: 74%

“…Fcgri and Fcgr3 as FcγR were also differently expressed in the RAW264.7 cells in our previous studies. 19,43…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…19 FeNPs also trigger production of many kinds of cytokines. 19 The results indicate a potential application of FeNPs in cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

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In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages

et al. 2019

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A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles: Antiviral Mechanisms Investigation

et al. 2023

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Prevention of spreading viral respiratory disease, especially in case of a pandemic such as coronavirus disease of 2019 (COVID-19), has been proved impossible without considering obligatory face mask-wearing protocols for both healthy and contaminated populations. The widespread application of face masks for long hours and almost everywhere increases the risks of bacterial growth in the warm and humid environment inside the mask. On the other hand, in the absence of antiviral agents on the surface of the mask, the virus may have a chance to stay alive and be carried to different places or even put the wearers at risk of contamination when touching or disposing the masks. In this article, the antiviral activity and mechanism of action of some of the potent metal and metal oxide nanoparticles in the role of promising virucidal agents have been reviewed, and incorporation of them in an electrospun nanofibrous structure has been considered an applicable method for the fabrication of innovative respiratory protecting materials with upgraded safety levels. Graphical Abstract

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Gene Expression and Transcriptome Profiling of Changes in a Cancer Cell Line Post-Exposure to Cadmium Telluride Quantum Dots: Possible Implications in Oncogenesis

et al. 2021

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Cadmium telluride quantum dots (CdTe-QDs) are acquiring great interest in terms of their applications in biomedical sciences. Despite earlier sporadic studies on possible oncogenic roles and anticancer properties of CdTe-QDs, there is limited information regarding the oncogenic potential of CdTe-QDs in cancer progression. Here, we investigated the oncogenic effects of CdTe-QDs on the gene expression profiles of Chang cancer cells. Chang cancer cells were treated with 2 different doses of CdTe-QDs (10 and 25 μg/ml) at different time intervals (6, 12, and 24 h). Functional annotations helped identify the gene expression profile in terms of its biological process, canonical pathways, and gene interaction networks activated. It was found that the gene expression profiles varied in a time and dose-dependent manner. Validation of transcriptional changes of several genes through quantitative PCR showed that several genes upregulated by CdTe-QD exposure were somewhat linked with oncogenesis. CdTe-QD-triggered functional pathways that appear to associate with gene expression, cell proliferation, migration, adhesion, cell-cycle progression, signal transduction, and metabolism. Overall, CdTe-QD exposure led to changes in the gene expression profiles of the Chang cancer cells, highlighting that this nanoparticle can further drive oncogenesis and cancer progression, a finding that indicates the merit of immediate in vivo investigation.

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Effects of Iron Nanoparticles on Immune Response of Two Immunocytes Like Virus

Cited by 3 publications

References 47 publications

In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages

In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages

A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles: Antiviral Mechanisms Investigation

Gene Expression and Transcriptome Profiling of Changes in a Cancer Cell Line Post-Exposure to Cadmium Telluride Quantum Dots: Possible Implications in Oncogenesis

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