Effects of Irritable Bowel Syndrome on Daily Activities Vary Among Subtypes Based on Results From the IBS in America Survey

Ballou, Sarah; McMahon, Courtney; Lee, Ha Neul; Katon, Jesse; Shin, Andrea; Rangan, V. Kasturi; Singh, Prashant; Nee, Judy; Camilleri, Michael; Lembo, Anthony; Iturrino, Johanna

doi:10.1016/j.cgh.2019.08.016

Cited by 75 publications

(72 citation statements)

References 21 publications

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“…The lack of significant individual symptom differences between groups could also be due at least in part to the fact that our IBS groups were heterogenous with respect to predominant bowel habit. Significant IBS bowel habit differences in the prevalence of individual symptoms 61 and impact on daily activities have been reported 62 …”

Section: Discussionmentioning

confidence: 99%

Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS

Lenhart

Naliboff

Shih

et al. 2020

Neurogastroenterology Motil

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Background Although irritable bowel syndrome (IBS) is more common in women, little is known about the role of hormonal changes and menopause in IBS. This study aimed to evaluate for differences in gastrointestinal (GI) and psychological symptoms between pre‐ and postmenopausal women with IBS compared to age‐matched men with IBS. Methods Patients with Rome‐positive IBS were identified. Premenopausal women were <45 years of age with regular menses. Postmenopausal women were ≥45 years without menses for at least 1 year. Younger men were <45 years, and older men were ≥45 years. Questionnaires measured severity of IBS symptoms, somatic symptoms, health‐related quality of life (HRQOL), and psychological symptoms. Multivariable linear or logistic regressions evaluating relationships between age and sex were performed. Key Results 190 premenopausal women (mean age 30.25 years), 52 postmenopausal women (mean age 54.38 years), 190 men <45 years (mean age 30.45 years), and 52 men ≥45 years (mean age 53.37 years) were included. Postmenopausal IBS women had greater severity of IBS symptoms (P = .003) and worse physical HRQOL (P = .048) compared to premenopausal women. No differences were observed between age‐matched older and younger IBS men. Constipation increased with age for both sexes but was the principal IBS subtype in women only. Conclusions and Inferences Postmenopausal women with IBS have more severe IBS symptoms than premenopausal women, while no comparable age‐related changes were seen in IBS men. The modulatory effect of female sex hormones on brain‐gut interactions which affect visceral perception and GI function likely contributes to these findings.

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Section: Discussionmentioning

confidence: 99%

Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS

Lenhart

Naliboff

Shih

et al. 2020

Neurogastroenterology Motil

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“…59 Indeed, patients with IBS-D report more avoidance of places without bathrooms and reluctance to leave home, whereas individuals with IBS with predominant constipation (IBS-C) are more likely to report avoiding sex, difficulty concentrating and feeling self-conscious. 60 The effects of IBS symptoms on work, including loss of earnings, socialising and the ability to travel also have a negative effect on QoL. 61 Overall, patients with IBS report feeling a loss of freedom and spontaneity, highlight the unpredictability of their symptoms, and can feel stigmatised by family, friends and physicians, who might struggle to understand the effects on their life.…”

Section: [H2] Quality Of Lifementioning

confidence: 99%

Global burden of irritable bowel syndrome: trends, predictions and risk factors

Black

Ford

2020

Nat Rev Gastroenterol Hepatol

341

237

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Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction worldwide and is defined according to patterns of gastrointestinal symptoms, as described by the Rome diagnostic criteria. However, these criteria, developed with reference to research conducted largely in Western populations, might be limited in their applicability to other countries and cultures. Epidemiological data show a wide variation in the prevalence of IBS globally and more rigorous studies are needed to accurately determine any differences that might exist between countries and potential explanations. The effect of IBS on the individual, in terms of their quality of life, and on healthcare delivery and society, in terms of economic costs, is considerable. Although the magnitude of these effects seems to be comparable between nations, their precise nature can vary based on the existence of societal and cultural differences. The pathophysiology of IBS is complex and incompletely understood; genetics, diet and the gut microbiome are all recognised risk factors, but the part they play might be influenced by geography and culture, and hence their relative importance might vary between countries. This Review aims to provide an overview of the burden of IBS in a global context, to discuss future implications for the care of people with IBS worldwide, and to identify key areas for further research.

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“…However, only one prior study so far has validated quality of life (QOL) in specific IBS subtypes, namely constipation-dominant (IBS-C) versus diarrhea-dominant IBS (IBS-D). In this issue of Clinical Gastroenterology and Hepatology, Ballou et al 14 compared the impairment of specific daily activities in IBS subtypes using the nationwide "Life with IBS" survey in 3254 people from 50 different US states. Although the perceived effects of IBS symptoms on productivity are similar, IBS subtypes differ in specific areas of daily function.…”

Section: Effects Of Irritable Bowel Syndrome On Dailymentioning

confidence: 99%

Issue Highlights

Manns

2019

Clinical Gastroenterology and Hepatology

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Effects of Irritable Bowel Syndrome on Daily Activities Vary Among Subtypes Based on Results From the IBS in America Survey

Cited by 75 publications

References 21 publications

Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS

Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS

Global burden of irritable bowel syndrome: trends, predictions and risk factors

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