Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice

Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?

“…This was particularly important in the present study because SI increased locomotion in the PM-DAT despite increasing immobility in the FST and in the TST. This increase in locomotor activity induced by SI is in line with the results of previous studies [47][48][49][50] that have linked it to both a decrease in the basal turnover of serotonin in the nucleus accumbens 48 and an increase in the activity of dopamine neurons in the mesoaccumbens system. 50 Avoidance of the aversive enclosed arm in the PM-DAT on testing has been validated as a measurement of retention because amnestic manipulations decrease it.…”

Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test

“…The food restriction procedure used in these experiments involved individual housing that could have had behavioral effects by itself (Siegfried et al 1981). Although the problem of which environmental manipulation is affecting behavior is not a question here, it should be pointed out that in DBA mice food restriction and repeated restraint reduce immobility in the FST (Cabib et al 1995) while individual housing with unlimited access to food actually enhances it (Cabib et al 2002).…”

Olfaction, GABAergic neurotransmission in the olfactory bulb, and intermale aggression in mice: Modulation by steroids

“…Social isolation lowers GAD activity (Blinderman et al, 1979) and GABA content in the olfactory bulbs of outbred C3II/IIe mice (Early and Leonard, 1977) and inbred C57 and DBA mice (Simler et aL, 1982), but also increases aggression (Ginsburg and Allee, 1942;Kahn 1954;Lagerspetz and Lagerspetz, 1971;Crawley et al, 1975;Siegfried et al, 1981;Hayashi, 1991). Thus, several manipulations of GABA content in the olfactory bulb are consistently associated with changes in aggression.…”