Effects of isotretinoin on serum lipids and lipoproteins, liver and thyroid function

Marsden, J.R.; Trinick, Thomas R.; Laker, M. F.; Shuster, Sam

doi:10.1016/0009-8981(84)90074-3

Cited by 35 publications

(10 citation statements)

References 18 publications

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“…One of these side effects is increased cholesterol levels (Lyons et al, 1982;Zech et al, 1983;Marsden et al, 1984;Bershad et al, 1985;Michaelsson et al, 1986;Barth et al, 1993;Fex et al, 1996;Ostlere et al, 1996;Lestringant et al, 1997). Here, the effects of 13-cis-RA on serum chemistry were studied after oral treatment with doses that mimic plasma levels achieved by humans taking the recommended doses.…”

Section: Discussionmentioning

confidence: 96%

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Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

Cisneros¹,

Gough²,

Patton³

et al. 2005

J. Appl. Toxicol.

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Currently used to treat severe acne, 13-cis-retinoic acid (13-cis-RA) is under investigation for its anticancer effects as is the isomer, all-trans-retinoic acid (all-trans-RA). Here, the effects of oral 13-cis-RA or all-trans-RA treatment on serum chemistry, leptin and adiponectin levels were evaluated. Adult Sprague-Dawley rats were gavaged once daily for 7 consecutive days with 13-cis-RA (7.5 or 15 mg kg(-1)), all-trans-RA (10 or 15 mg kg(-1)) (n=24/sex/dose), or soy oil (n=16/sex) and blood was sampled 30-480 min after the last gavage. The body weight was unaffected; however, the liver/body weight ratios were increased by both doses of all-trans-RA. Sex differences were noted for levels of cholesterol, creatine, triglycerides, albumin, alanine aminotransferase and total protein. Both doses of all-trans-RA reduced albumin levels to approximately 90% of the control and total protein levels to approximately 93% of the control while substantially elevating triglyceride levels to approximately 66%-99% above the control. Additionally, triglyceride levels of the 15 mg kg(-1) 13-cis RA group were approximately 62% higher than the controls and total protein levels were approximately 5% less. Glucose levels were affected by sex and RA treatment in that males treated with 15 mg kg(-1) of 13-cis-RA or 10 mg kg(-1) all-trans-RA had lower (13%-19%) levels than the same-sex controls; however, females were not similarly affected. Neither 13-cis-RA nor all-trans-RA treatment had significant effects on the levels of blood urea nitrogen, aspartate amino transferase, leptin or adiponectin. On a mg kg(-1) basis, all-trans-RA was more potent than 13-cis-RA. These results replicate previous findings of RA-induced increased triglyceride levels. Additionally, several new findings indicate there may be sex-specific effects of RA treatment. Finally, neither treatment appeared to alter the typical diurnal cycles of these endpoints.

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Section: Discussionmentioning

confidence: 96%

“…While some authors have previously published similar results (Barth et al, 1993), others have reported an AST increase after several weeks of 13-cis-RA treatment (Marsden et al, 1984;Altman et al, 2002).…”

mentioning

confidence: 90%

Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

Cisneros¹,

Gough²,

Patton³

et al. 2005

J. Appl. Toxicol.

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“…ISO has been controversially shown to cause reversible hypo- and hyperthyroidism [3,13,32]. Several other vitamin A derivatives also influence thyroid metabolism.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Different Doses of Isotretinoin on Pituitary Hormones

Karadağ¹,

Takçı²,

Ertuğrul³

et al. 2015

Dermatology

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Background: There are a limited number of studies investigating the side effects and effectiveness of various doses of isotretinoin (ISO). We have previously shown that high-dose ISO affects pituitary hormones. Objectives: To our knowledge, there is no study in the literature looking into the effects of various doses of ISO on pituitary hormones. We searched pituitary hormones in three groups of different doses in acne patients. Methods: We included 105 acne vulgaris patients from two different centers. We divided the patients into three groups; the first group received 0.5-1 mg/kg/day, the second 0.2-0.5 mg/kg/day and the third intermittent 0.5-1 mg/kg/day (only 1 week in 1 month) ISO treatment. Blood samples were collected for biochemistry and hormone analysis, before the treatment and after 3 months. Results: After 3 months of treatment with ISO, luteinizing hormone (LH) (p < 0.001), prolactin (p < 0.001), total testosterone (p < 0.001), adrenocorticotropic hormone (ACTH) (p < 0.001), cortisol (p < 0.001), insulin-like growth factor-binding protein 3 (p < 0.001), insulin-like growth factor 1 (IGF-1) (p = 0.002), growth hormone (GH) (p = 0.002) and free T3 (fT3) (p < 0.001) levels had decreased significantly. Furthermore, we split data into three different groups. Among the patients receiving intermittent-dose ISO, LH, ACTH, IGF-1, GH and fT3 measurements lost significance. Most of the significant measurements observed in the whole group were also significant among the patients receiving high-dose ISO. Additionally, dehydroepiandrosterone sulfate (p = 0.003) levels increased, and free T4 levels decreased significantly. Conclusions: ISO affects pituitary hormones at all of these three doses. The differences in pituitary hormones are more pronounced in high-dose treatment. The weakest effect was observed in the intermittent-dose group. Choosing lower doses of ISO may decrease side effects, however the effectiveness of the treatment may also be diminished. ISO, by affecting the PPARγ/RXR system, may affecting hormone systems. These changes in various hormone systems may be related to the effectiveness of ISO.

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“…Eight male subjects aged 18-24 years, all non-smokers, with severe acne were treated with 0.5 mg of isotretinoin day-' kg-1; all gave informed written consent before participating in the study. Before treatment began and after 4 weeks, the following measurements were made after a 14 h fast by using previously described techniques (Marsden et al, 1984a); levels of cholesterol, triglyceride, high-density lipoprotein (HDL)-cholesterol, aspartate aminotransferase ~y-glutamyltranspeptidase, alkaline phosphatase, bilirubin, thyroxine (T4), tri-iodothyronine (T3) and T3 uptake. Levels of u-1 -acid glycoprotein were measured by automated immune precipitation.…”

Section: Introductionmentioning

confidence: 99%

Antipyrine Clearance and α1-Acid Glycoprotein Levels after Isotretinoin

1985

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Eight male subjects aged 18-24 years were treated with 0.5 mg of isotretinoin day-1 kg -1. After 4 weeks levels of cholesterol (P < 0.05) and triglyceride (P < 0.05) were increased and levels of high-density lipoprotein (HDL)-cholesterol were decreased (P < 0.05). Concentrations of aspartate aminotransferase (P < 0.01) and γ-glutamyltranspeptidase (P < 0.01) were higher after treatment; increased alkaline phosphatase and a reduction in bilirubin levels did not reach statistical significance. Values for thyroxine were reduced after isotretinoin and free thyroxine index was lower (P < 0.01). Measurements of salivary clearance of antipyrine and levels of α 1-acid glycoprotein were lower after treatment but these differences did not reach statistical significance. The findings suggest that there is a small decrease in hepatic microsomal-enzyme activity after isotretinoin and that the unwanted effects on lipids, liver and thyroid function are unlikely to be due to hepatic microsomal-enzyme induction.

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Effects of isotretinoin on serum lipids and lipoproteins, liver and thyroid function

Cited by 35 publications

References 18 publications

Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

The Effect of Different Doses of Isotretinoin on Pituitary Hormones

Antipyrine Clearance and α1-Acid Glycoprotein Levels after Isotretinoin

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