Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition

Johnson, Bankole A.; Roache, John D.; Ait-Daoud, Nassima; Wallace, Christopher L.; Wells, Lynda T.; Wang, Yanmei

doi:10.1007/s00213-004-1998-0

Cited by 30 publications

(36 citation statements)

References 34 publications

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“…Similar to our previous study (Johnson et al, 2005b), intravenous methamphetamine administration was associated with significant and orderly increases in psychomotor performance and attention in methamphetamine-dependent individuals.…”

Section: Discussionsupporting

confidence: 89%

“…Rapid Visual Information Processing Task-The rapid visual information processing task (RVIPT) is a recognized computer-based test of attention and concentration (Johnson et al, 1996(Johnson et al, , 2005bSilverstone et al, 1992). In the RVIPT, subjects monitor digits that are presented sequentially on a computer screen at a rate of 100 per minute for 7.5 min.…”

Section: Experimental Measuresmentioning

confidence: 99%

“…Yet, while ample studies have demonstrated that d-amphetamine enhances cognitive processing on computerized tasks that test performance and attention (Gunne, 1977;Harvey, 1987;Johnson et al, 1996;Spiegel, 1979;Weiss and Laties, 1962), presumably due to enhancement of catecholamine Robbins, 1987, 1992) and particularly dopamine release (Drachman, 1977), only one study has reported on the effects of intravenously administered methamphetamine on cognitive performance in methamphetamine-dependent individuals (Johnson et al, 2005b). In that study, intravenous dmethamphetamine produced dose-dependent increases in attention, concentration, and psychomotor performance.…”

Section: Introductionmentioning

confidence: 99%

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Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Johnson

Roache

Ait-Daoud

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Methamphetamine-dependent individuals often cite the need to maintain enhanced cognitive performance and attention as a reason for continuing or relapsing to drug-taking. Further, methamphetamine addicts might not comply with taking a potentially therapeutic medication if it had a profound effect on these cognitive processes. Topiramate, a sulfamate-substituted fructopyranose derivative, has been suggested as a putative therapeutic medication for treating methamphetamine dependence. Examination of topiramate's effects on cognitive performance and attention is a clinically and scientifically important component of understanding its potential therapeutic profile. In 10 male and female individuals who met DSM-IV criteria for methamphetamine dependence, we examined the effects of low (50 mg b.i.d.)-and high (100 mg b.i.d.)-dose topiramate -in both the presence and absence of low (15 mg)-and high (30 mg)-dose intravenous methamphetamine -on cognitive performance, attention, and concentration on the rapid visual information processing task and the digit symbol substitution test. Intravenous methamphetamine enhanced cognitive performance, attention, and concentration among recently withdrawn methamphetamine addicts -an effect that hitherto had not been well characterized. Topiramate's cognitive effects were mixed and rather paradoxical, with a tendency to improve attention and concentration both alone and in the presence of methamphetamine while worsening psychomotor retardation. No deleterious interaction occurred between topiramate and methamphetamine on any of these cognitive processes. While clinical studies with topiramate should Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Discussionsupporting

confidence: 89%

Section: Experimental Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Johnson

Roache

Ait-Daoud

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Nevertheless, the data generally agree with results from studies assessing the effects of oral (Johnson et al, 2000;Hart et al, 2002;Silber et al, 2006) and i.v. (Johnson et al, 2005b) methamphetamine on performance. These data are also consistent with findings from studies that have assessed the effects of oral methamphetamine on performance of sleep-deprived individuals and research participants subjected to abrupt work-shift schedule changes (Wiegmann et al, 1996;Hart et al, 2003Hart et al, , 2005.…”

Section: Discussionmentioning

confidence: 99%

Acute Physiological and Behavioral Effects of Intranasal Methamphetamine in Humans

Hart

Gunderson

Perez

et al. 2007

Neuropsychopharmacol

116

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Intranasal methamphetamine abuse has increased dramatically in the past decade, yet only one published study has investigated its acute effects under controlled laboratory conditions. Thus, the current study examined the effects of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological measures. Eleven nontreatment-seeking methamphetamine abusers (two females, nine males) completed this four-session, in-patient, within-participant, double-blind study. During each session, one of four intranasal methamphetamine doses (0, 12, 25, and 50 mg/70 kg) was administered and methamphetamine plasma concentrations, cardiovascular, subjective, and psychomotor/cognitive performance effects were assessed before drug administration and repeatedly thereafter. Following drug administration, methamphetamine plasma concentrations systematically increased for 4 h postdrug administration then declined. Methamphetamine dose dependently increased cardiovascular measures and 'positive' subjective effects, with peaks occurring approximately 5-15 min after drug administration, when plasma levels were still ascending. In addition, cognitive performance on less complicated tasks was improved by all active methamphetamine doses, whereas performance on more complicated tasks was improved only by the intermediate doses (12 and 25 mg). These results show that intranasal methamphetamine produced predictable effects on multiple behavioral and physiological measures before peak plasma levels were observed. Of interest is the dissociation between methamphetamine plasma concentrations with cardiovascular measures and positive subjective effects, which might have important implications for potential toxicity after repeated doses. INTRODUCTIONAlthough methamphetamine abuse has increased dramatically over the past decade, much of our knowledge about its acute effects in humans is anecdotal. The drug is frequently abused via the intranasal, i.v., and smoked routes (Domier et al, 2000; Community Epidemiology Work Group, 2005), but few studies have evaluated the acute effects of methamphetamine in humans using these routes of administration. The majority of studies conducted with humans have focused primarily on the cardiovascular and subjective effects produced by oral methamphetamine, a route of administration least often associated with abuse presumably due to its slow onset of effects. The onset of peak effects produced by oral methamphetamine does not occur until about 90 min after the administration (Hart et al, 2001a). By comparison, peak effects produced by intranasal, smoked, and i.v. methamphetamine occur within 15 min (Harris et al, 2003;Newton et al, 2005).Given that the rapidity of drug-related effects is a critical determinant of abuse liability (Hatsukami and Fischman, 1996), it is surprising that only a few studies have examined methamphetamine-related effects via routes of administration other than oral (eg Cook et al, 1993;Mendelson et al, 1995;Newton et al, 2006). Although inhalation by s...

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“…One approach is to inhibit the reinforcing effects of the drug with small molecule receptor antagonists. [2][3][4][5][6] A second approach, and one pursued by our laboratory, is to block distribution of METH into the brain, its primary site of action, by administration of an anti-METH monoclonal antibody (mAb). [7][8][9][10] These high molecular weight (150 kDa) proteins interact strongly with METH (K d < 100 nM), decreasing the volume of distribution of METH and blocking METH penetration into the brain.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of total methamphetamine and active metabolites in rat tissue by liquid chromatography with tandem mass spectrometric detection

Hendrickson¹,

Laurenzana²,

Owens³

2006

AAPS J

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High-throughput liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) methodology for the determination of methamphetamine (METH), amphetamine (AMP), 4-hydroxymethamphetamine (4-OH-METH), and 4-hydroxyamphetamine (4-OH-AMP) was developed and validated using simple trichloroacetic acid sample treatment. The method was validated in rat serum, brain, and testis. Lower limits-of-quantitation (LOQ) for METH and AMP were 1 ng • mL − 1 using positive ion electrospray tandem mass spectrometry (MS/MS). The accuracy of the method was within 25% of the actual values over a wide range of analyte concentrations. The within-assay precision was better than 12% (co effi cient of variation). The method was linear over a wide dynamic range (0.3-1000 ng • mL − 1 ). Quantitation was possible in all 3 matrices using only serum standards because of minimal matrix-associated ion effects or the use of an internal standard. Finally, the LC-MS/MS method was used to determine serum, brain, and testis METH and AMP concentrations during a subcutaneous infusion (5.6 mg kg − 1 day − 1 ) of METH in rats. Concentrations of 4-OH-AMP and 4-OH-METH were below the LOQ in experimental samples. The bias introduced by using serum calibrators for the determination of METH and AMP concentrations in testis and brain was less than 8% and insignifi cant relative to the interanimal variability.K EYWORDS: methamphetamine , rats , LC-MS/MS , matrix ion effects

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Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition

Abstract: Our results do not support the further testing of isradipine as a medication for improving the cognitive impairments that have been associated with chronic methamphetamine use.

Cited by 30 publications

References 34 publications

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Acute Physiological and Behavioral Effects of Intranasal Methamphetamine in Humans

Quantitative determination of total methamphetamine and active metabolites in rat tissue by liquid chromatography with tandem mass spectrometric detection

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