Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits

Ahn, Chang Beohm; Song, Choon Ho; Kim, Woo Hwan; Kim, Yong Keun

doi:10.1016/s0378-8741(02)00124-1

Cited by 29 publications

(13 citation statements)

References 19 publications

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“…Our findings showed that both NAC and DMSA ameliorated the decrease in serum and mRNA expression of antioxidants. These findings were confirmed in previous reports for both LA and HgCl 2 using curcumin and selenium, respectively (Agarwal et al, 2007;Ahn et al, 2002; Abu El-Saad et al, 2016). NAC interacts most powerfully with the free radicals, it exerts an indirect effect on antioxidant status, since it restores catalase and is a precursor for synthesis of GSH, (Arakawa & Ito, 2007) thus providing enhanced defense against toxin-induced oxidative insult (Abu El-Saad & Elgerbed, 2010).…”

Section: Discussionsupporting

confidence: 89%

“…Liver and kidney damage, gastrointestinal diseases, and alterations in central nervous system, blood pressure and vitamin D metabolism occurred after exposure to LA and HgCl 2 (Ansari et al, 2013;Ahn et al, 2002). Furthermore, antioxidants, plant extracts and chelating agents have the potential to inhibit these effects (Kumar et al, 2013;Jarrar, 2003;Mehana et al, 2012;Ekor et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Baiomy¹,

Soliman²,

Saad³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Heavy metals that normally cause problems are mercury (HgCl 2 ) and lead acetate (LA). Chelating and inhibitor agents are the target to treat and overcome metal toxicity. The current study has been carried out to evaluate the protective effects of N-acetyl cysteine (NAC) and meso 2,3 dimercaptosuccinic acid (DMSA) against HgCl 2 and LA toxicity. Materials and Methods: Ninety male Wistar rats were divided into nine equal groups. The groups were administered NAC and/or DMSA in presence or absence of LA (LA; 0.2% in drinking water) or HgCl 2 (2 mg/kg BW) for 2 consecutive months. Serum and organs were collected for biochemical, genetic and histopathological changes. Results: Biochemical results revealed that LA and HgCl 2 significantly increased the levels of liver and kidney biomarkers. Administration of NAC and DMSA considerably improved these altered changes. LA and HgCl 2 decreased serum levels of antioxidants and were ameliorated in NAC and DMSA administered rats. LA and HgCl 2 administration upregulated expression of IL-1β and IL-8 that were normalized by NAC and DMSA. Kidneys of LA and HgCl 2 groups showed intraluminal hyaline casts. Kidneys of DMSA-administrated rats showed mild hydropic degeneration of renal tubular epithelium in LA and HgCl 2 groups. Kidneys of NAC administrated rats showed atrophy of capillary tufts. Kidneys of LA and HgCl 2 administered rats which received DMSA and NAC showed normal glomerular structure. Liver histopathology showed sever changes that were ameliorated by NAC and DMSA. Conclusion: Taken together, usage of NAC and DMSA provide significant protection against LA and HgCl 2 -induced hepatotoxicity and nephrotoxicity in male Wistar rats.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Baiomy¹,

Soliman²,

Saad³

et al. 2017

Afr J Tradit Complement Altern Med

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“…As a result of this study, it was found that MDA levels declined significantly in the group added walnut extract [37]. In another study, the effects of liquid extract of walnut against cyclophosphamide (CP)-induced biochemical toxicity.…”

Section: Discussionmentioning

confidence: 65%

The effects of Juglans regia L. (walnut) extract on certain biochemical paramaters and in the prevention of tissue damage in brain, kidney, and liver in CCl₄ applied Wistar rats

Aydın

Gökçe

Yılmaz

2015

Turkish Journal of Biochemistry

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CCl 4 uygulanan Wistar sıçanlarda beyin, böbrek ve karaciğer doku hasarlarının önlenmesinde ve bazı biyokimyasal parametreler üzerine Juglans regia L. (ceviz) ekstraktının etkileri Abstract: Objective: The purpose of this study is to demonstrate protective effects of walnut samples on CCl 4 -induced tissue damage in vivo.Methods: Walnut fruits were extracted and then subjected to vitamin and flavonoid analyses. The extracts obtained were injected intraperitoneally every other day to Wistar male rats given carbon tetrachloride (CCl 4 ) and the animals were decapitated at the end of the study period. The brain, kidney, and liver tissues were removed and lipid peroxidation (LPO) measurements were done in the lipid fraction generated. The fatty acids in the lipid extract were analyzed by gas chromatography after converting them into methyl esters. In addition, the amounts of glutathione, protein, and vitamins were analyzed.

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“…Considering that oxidative stress and endogenous thiol depletion are involved in inorganic Hg toxicity, it has been suggested that antioxidants could contribute to the treatment of Hg poisoning [13,14]. Antioxidants like melatonin, curcumin, and vitamin E have been found to play a protective effect against mercuric chloride (HgCl2)-induced acute renal toxicity [15][16][17]. Similarly, a number of plant extracts with antioxidant properties have been shown to inhibit HgCl2-induced toxicity [16,18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Ansar

2015

Biol Trace Elem Res

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Selenium is an essential cofactor in the key enzymes involved in cellular antioxidant defense. This study was designed to investigate the protective effects of selenium on mercury chloride (HgCl2)-induced toxicity. Male Wistar rats were randomly divided into four groups of six animals each. The first group was control; the second group was treated with mercuric chloride (HgCl2: 50 mg/kg/bw). The third group was treated with sodium selenite (Se 0.2 mg/kg/bw), and the fourth group received Se (0.2 mg/kg/bw) plus HgCl2 (50 mg/kg for 24 h). The influence of Se on mercury induced levels of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) and zinc, copper, and iron in serum of rats were observed. The serum MDA, SOD, zinc, and iron concentrations were found to be statistically different among the control and toxin-treated group. The serum levels of IL-6, IL-10, and TNF-α were also measured. There was a significant decrease in the levels of TNF-α, IL-6, and IL-10 in toxin-treated group II compared with that of the control group (p < 0.05). A significant increase in the serum levels of inflammatory cytokines IL-6, TNF-α, and IL-10 after administration of Se seemed to counteract some of the damage, as indicated by differences in the serum concentrations of major elements.

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Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits

Cited by 29 publications

References 19 publications

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

The effects of Juglans regia L. (walnut) extract on certain biochemical paramaters and in the prevention of tissue damage in brain, kidney, and liver in CCl₄ applied Wistar rats

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

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Effects of Juglans sinensis Dode extract and antioxidant on mercury chloride-induced acute renal failure in rabbits

Cited by 29 publications

References 19 publications

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

The effects of Juglans regia L. (walnut) extract on certain biochemical paramaters and in the prevention of tissue damage in brain, kidney, and liver in CCl4 applied Wistar rats

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

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The effects of Juglans regia L. (walnut) extract on certain biochemical paramaters and in the prevention of tissue damage in brain, kidney, and liver in CCl₄ applied Wistar rats