Effects of Juniperus oxycedrus ssp. oxycedrus on tissue lipid peroxidation, trace elements (Cu, Zn, Fe) and blood glucose levels in experimental diabetes

Orhan, Nilüfer; Berkkan, Aysel; Orhan, Didem Deliorman; Aslan, Mustafa; Ergün, Fatma

doi:10.1016/j.jep.2010.11.002

Cited by 27 publications

(16 citation statements)

References 23 publications

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“…This study indicates treatment of diabetic rats for 10 days with Joso fruit and leaf crude extracts decreased blood glucose levels. Moreover, extracts decreased levels of lipid peroxidation in liver and kidney tissues remarkably and augmented Zn concentrations in liver (Orhan et al, 2011).…”

Section: Discussionmentioning

confidence: 92%

Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Orhan

Aslan

Pekcan

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 92%

Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Orhan

Aslan

Pekcan

et al. 2012

Journal of Ethnopharmacology

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“…STZ‐induced diabetes has been reported to increase Cu content associated with the metallothionein of rat liver and kidney tissues (Orhan et al. ).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effects of Mangifera indica Kernel Flour‐supplemented diet in streptozotocin‐induced type 2 diabetes in rats

Irondi

Oboh

Akindahunsi

2016

Food Science & Nutrition

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Our previous report showed that Mangifera indica kernel flour (MIKF) is a rich source of pharmacologically important flavonoids and phenolic acids; and that its methanolic extract inhibits some key enzymes linked to the pathology and complications of type 2 diabetes (T2D) in vitro. Hence, this study evaluated the antidiabetic effects of 10% and 20% MIKF‐supplemented diets in T2D in rats. T2D was induced in rats using a high‐fat diet (HFD), low‐dose streptozotocin (HFD/STZ) model, by feeding the rats with HFD for 2 weeks followed by single dose administration of STZ (40 mg/kg body weight, intraperitoneally). The diabetic rats were later fed the MIKF‐supplemented diets, or administered with metformin (25 mg/kg b.w.) for 21 days; the control rats were fed basal diet during this period. Intake of the MIKF‐supplemented diets resulted in significant (P < 0.05) improvement in the fasting blood glucose, hepatic glycogen, glycosylated hemoglobin, lipid profile, plasma electrolytes, hepatic and pancreatic malonaldehyde, and the liver function markers of the diabetic rats, compared with the diabetic control rats. The ameliorative effect of 20% MIKF‐supplemented was comparable (P > 0.05) with that of metformin administration in the diabetic rats. It is concluded that M. indica kernel flour has antidiabetic effects in T2D rats, and could therefore be a promising nutraceutical therapy for the management of T2D and its associated complications.

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“…A standardized diet was offered every two hours, with a total of 125 kcal/kg/day (Table 1). Iron and zinc contents of the food were determined using a food contents table 3. Liquid intake was standardized at 10–20 mL/kg to maintain a constant urinary flow and avoid dehydration.…”

Section: Methodsmentioning

confidence: 99%

Impact of Aging on Urinary Excretion of Iron and Zinc

Pfrimer

Micheletto

Marchini

et al. 2014

Nutr Metab Insights

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PROJECTData about the influence of aging on urinary excretion of iron and zinc are scarce. The objective of the present study was to compare the concentration of zinc and iron in the urine of healthy elderly subjects and younger adults.PROCEDURESeven healthy elderly subjects and seven younger adults were selected and submitted to biochemical, clinical, and nutritional tests. After a fasting period, 12-hour urine was collected for the determination of iron and zinc concentrations by graphite furnace atomic absorption spectrophotometry.RESULTSUrinary zinc and iron concentrations of the elderly subjects were not significantly different from that of younger adults. However, the total zinc and iron urinary clearance in 24 hours for the elderly was significantly higher compared with that of younger adults.CONCLUSIONThere is an increase in urinary iron and zinc clearance with aging. The values reported in this manuscript may be used as references in future studies.

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Effects of Juniperus oxycedrus ssp. oxycedrus on tissue lipid peroxidation, trace elements (Cu, Zn, Fe) and blood glucose levels in experimental diabetes

Cited by 27 publications

References 23 publications

Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Antidiabetic effects of Mangifera indica Kernel Flour‐supplemented diet in streptozotocin‐induced type 2 diabetes in rats

Impact of Aging on Urinary Excretion of Iron and Zinc

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