Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: behavioural and autoradiographic studies

Berg, C.L. van den; Ree, Jan M. van; Spruijt, Berry M.; Kitchen, Ian

doi:10.1046/j.1460-9568.1999.00717.x

Cited by 68 publications

(28 citation statements)

References 57 publications

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“…There have also been several studies reporting altered social behaviors in rodents exposed to social isolation during adolescence. Isolation rearing has consistently been found to increase aggressive behaviors in male rats; however the effect on non-aggressive behaviors has been less consistent with some studies showing a significant decrease in social interaction while others found a significant increase in social behaviors (Lukkes et al, 2009; Meng et al, 2010; Van den Berg et al, 1999; Zhao et al, 2009). One possible reason for the contrasting results may be due to the inconsistent period of time rats were socially isolated (2–8 weeks).…”

Section: Social Interactionmentioning

confidence: 88%

Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia

Wilson¹,

Koenig²

2014

European Neuropsychopharmacology

111

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Negative symptoms (e.g., asociality and anhedonia) are a distinct symptomatic domain that has been found to significantly affect the quality of life in patients diagnosed with schizophrenia. Additionally, the primary negative symptom of asociality (i.e., withdrawal from social contact that derives from indifference or lack of desire to have social contact) is a major contributor to poor psychosocial functioning and has been found to play an important role in the course of the disorder. Nonetheless, the pathophysiology underlying these symptoms is unknown and currently available treatment options (e.g., antipsychotics and cognitive-behavioral therapy) fail to reliably produce efficacious benefits. Utilizing rodent paradigms that measure social behaviors (e.g., social withdrawal) to elucidate the neurobiological substrates that underlie social dysfunction and to identify novel therapeutic targets may be highly informative and useful to understand more about the negative symptoms of schizophrenia. Accordingly, the purpose of this review is to provide an overview of the behavioral tasks for assessing social functioning that may be translationally relevant for investigating negative symptoms associated with schizophrenia.

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Section: Social Interactionmentioning

confidence: 88%

Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia

Wilson¹,

Koenig²

2014

European Neuropsychopharmacology

111

View full text Add to dashboard Cite

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“…In contrast, rats in the present study were able to engage in unrestricted species-typical social behavior for 21 hr/day in the home cage, such as pinning, chasing, and rolling, as well complex behavioral sequences of deception and surprise attacks (Panksepp et al, 1984). These behaviors play a critical role in the development of normal social relationships in socially housed rats (Hol et al, 1999; Van den Berg et al, 1999; Von Frijtag et al, 2002), and likely play a modulatory role in social learning tasks in which responding depends on the degree of familiarity between the subjects (see, for example, Choleris et al, 1998; Galef et al, 1998; Kavaliers et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

Peer influences on drug self-administration

Peitz

Strickland²,

Pitts³

et al. 2013

Behavioural Pharmacology

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Social-learning theories of substance use propose that members of peer groups influence the drug use of other members by selectively modeling, reinforcing, and punishing either abstinence-related or drug-related behaviors. The objective of the present study was to examine social influences on cocaine self-administration in isolated and socially housed rats, with the caveat that the socially housed rats were tested simultaneously with their partner in the same chamber. To this end, male rats were obtained at weaning and housed in isolated or pair-housed conditions for 6 weeks. Rats were then implanted with intravenous catheters and cocaine self-administration was examined in custom-built operant conditioning chambers that allowed two rats to be tested simultaneously. For some socially housed subjects, both rats had simultaneous access to cocaine; for others, only one rat of the pair had access to cocaine. An econometric analysis was applied to the data, and the reinforcing strength of cocaine was measured by examining consumption (i.e., quantity demanded) and elasticity of demand as a function of price, which was manipulated by varying the dose and ratio requirements on a fixed ratio schedule of reinforcement. Cocaine consumption decreased as a function of price in all groups. Elasticity of demand did not vary across groups, but consumption was significantly lower in socially housed rats paired with a rat without access to cocaine. These data suggest that the presence of an abstaining peer decreases the reinforcing strength of cocaine, thus supporting the development of social interventions in drug abuse prevention and treatment programs.

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“…Specifically, administration of morphine enhances play behavior, while administration of the mu-opiate receptor antagonist naloxone, reduces rough and tumble play (Panksepp et al, 1985; Vanderschuren et al, 1995; Guard et al, 2002; Trezza and Vanderschuren, 2008). Moreover, when juveniles are socially isolated, thereby eliminating all experiences of play, both mu and kappa receptors are significantly up-regulation in several nuclei related to emotional regulation (Van den Berg et al, 1999b). Thus, the reduction in rough and tumble play behavior could be a symptom of a down-regulation of functional mu-opiate receptors in MOR-F1 males or conversely, their low levels of play could induce alterations in opiate receptors.…”

Section: Discussionmentioning

confidence: 99%

Adolescent Opiate Exposure in the Female Rat Induces Subtle Alterations in Maternal Care and Transgenerational Effects on Play Behavior

Johnson¹,

Carini²,

Schenk³

et al. 2011

Front. Psychiatry

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The non-medical use of prescription opiates, such as Vicodin® and MSContin®, has increased dramatically over the past decade. Of particular concern is the rising popularity of these drugs in adolescent female populations. Use during this critical developmental period could have significant long-term consequences for both the female user as well as potential effects on her future offspring. To address this issue, we have begun modeling adolescent opiate exposure in female rats and have observed significant transgenerational effects despite the fact that all drugs are withdrawn several weeks prior to pregnancy. The purpose of the current set of studies was to determine whether adolescent morphine exposure modifies postpartum care. In addition, we also examined juvenile play behavior in both male and female offspring. The choice of the social play paradigm was based on previous findings demonstrating effects of both postpartum care and opioid activity on play behavior. The findings revealed subtle modifications in the maternal behavior of adolescent morphine-exposed females, primarily related to the amount of time females’ spend nursing and in non-nursing contact with their young. In addition, male offspring of adolescent morphine-exposed mothers (MOR-F1) demonstrate decreased rough and tumble play behaviors, with no significant differences in general social behaviors (i.e., social grooming and social exploration). Moreover, there was a tendency toward increased rough and tumble play in MOR-F1 females, demonstrating the sex-specific nature of these effects. Given the importance of the postpartum environment on neurodevelopment, it is possible that modifications in maternal–offspring interactions, related to a history of adolescent opiate exposure, plays a role in the observed transgenerational effects. Overall, these studies indicate that the long-term consequences of adolescent opiate exposure can impact both the female and her future offspring.

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Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: behavioural and autoradiographic studies

Cited by 68 publications

References 57 publications

Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia

Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia

Peer influences on drug self-administration

Adolescent Opiate Exposure in the Female Rat Induces Subtle Alterations in Maternal Care and Transgenerational Effects on Play Behavior

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