Effects of ketamine and other rapidly acting antidepressants on hippocampal excitatory and inhibitory transmission

Global Proteomic Profile of Aluminum-Induced Hippocampal Impairments in Rats: Are Low Doses of Aluminum Really Safe?

“…Fourth, if another method of euthanasia were considered, it would also affect the molecular characteristics of the animals’ brains, such as the CO 2 chamber. As for the number of publications describing the effects of anesthetics on the hippocampus, there are some that aim to mimic the long-term use of anesthetics, and their recreational and illegal use (see [ 64 , 65 ]), an approach beyond the scope of our study.…”

Rapid-acting antidepressants and the circadian clock

“…Traditional antidepressants and anti-manic compounds (e.g., lithium, valproic acid) share overlapping mechanisms with ketamine and sleep deprivation by promoting neurogenesis and synaptic plasticity [ 11 , 175 – 178 ]. In animal models of depression, antidepressant effects of ketamine and SDT can take place in a matter of minutes to hours [ 104 , 105 , 179 ]. It is not yet known whether other classes of antidepressants promote neurogenesis within a similar time-frame.…”

Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala

“…In cognitive activities such as learning loss and fear expression, BDNF has different effects on the neural plasticity of hippocampal (HIP) and amygdala (AMG) networks [11,12]. For example, the acquisition and retrieval of contextual fear memory also requires coordinated neural activity, which is presented in the form of encoded information in HIP and transmitted to AMG to achieve contextual fear conditioning [13,14]. In addition, spatial learning is closely related to hippocampal dependent learning, and high level of traumatic stress damages hippocampal dependent spatial memory [15].…”