Rapid-acting antidepressants and the circadian clock

Sato, Shogo; Bunney, Blynn G.; Mendoza-Viveros, Lucía; Bunney, William E.; Borrelli, Emiliana; Sassone–Corsi, Paolo; Orozco-Solís, Ricardo

doi:10.1038/s41386-021-01241-w

Cited by 38 publications

(27 citation statements)

References 222 publications

(277 reference statements)

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“…In turn REV-ERBs repress Bmal1 transcription via the retinoic acid response element (RRE) [ 56 ]. The nuclear hormone receptors RORα, β, γ compete with REV-ERBs to activate Bmal1 transcription [ 57 , 58 ]. Rhythmic expression of clock output genes (so called “Clock-controlled genes”) is transcriptionally regulated by CLOCK: BMAL1 acting on E-box elements in their regulatory regions [ 59 ].…”

Section: The Mammalian Circadian Systemmentioning

confidence: 99%

“…Similarly, other studies have explored the antidepressant effects of various drugs and found activation of the mTOR signaling as a common pathway [ 231 , 232 ]. Overall, mTOR signaling mediates the behavioral response of many antidepressant drugs [ 57 , 214 , 216 , 233 – 236 ], which also indicates a critical role of the mTOR signaling in depression.…”

Section: Circadian Dysfunction Mtor and MDmentioning

confidence: 99%

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The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

2022

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Circadian (~24 h) rhythms in physiology and behavior are evolutionarily conserved and found in almost all living organisms. The rhythms are endogenously driven by daily oscillatory activities of so-called “clock genes/proteins”, which are widely distributed throughout the mammalian brain. Mammalian (mechanistic) target of rapamycin (mTOR) signaling is a fundamental intracellular signal transduction cascade that controls important neuronal processes including neurodevelopment, synaptic plasticity, metabolism, and aging. Dysregulation of the mTOR pathway is associated with psychiatric disorders including autism spectrum disorders (ASD) and mood disorders (MD), in which patients often exhibit disrupted daily physiological rhythms and abnormal circadian gene expression in the brain. Recent work has found that the activities of mTOR signaling are temporally controlled by the circadian clock and exhibit robust circadian oscillations in multiple systems. In the meantime, mTOR signaling regulates fundamental properties of the central and peripheral circadian clocks, including period length, entrainment, and synchronization. Whereas the underlying mechanisms remain to be fully elucidated, increasing clinical and preclinical evidence support significant crosstalk between mTOR signaling, the circadian clock, and psychiatric disorders. Here, we review recent progress in understanding the trilateral interactions and propose an “interaction triangle” model between mTOR signaling, the circadian clock, and psychiatric disorders (focusing on ASD and MD).

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Section: The Mammalian Circadian Systemmentioning

confidence: 99%

Section: Circadian Dysfunction Mtor and MDmentioning

confidence: 99%

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

2022

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“…A potential role has been recently proposed for the circadian clock in the mechanism of rapid antidepressant treatments, like SD and ketamine [ 60 ]. Duncan et al revealed an association between ketamine’s clinical antidepressant response and circadian-related wrist-activity parameters [ 39 ], finding that responders showed a phase-advanced activity rhythm and a decreased measure compared with nonresponders at baseline.…”

Section: Circadian Clock and Mood Regulationmentioning

confidence: 99%

A Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder

Wang

Gardner

et al. 2022

Mol Neurobiol

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Several studies have reported separate roles of adenosine receptors and circadian clockwork in major depressive disorder. While less evidence exists for regulation of the circadian clock by adenosine signaling, a small number of studies have linked the adenosinergic system, the molecular circadian clock, and mood regulation. In this article, we review relevant advances and propose that adenosine receptor signaling, including canonical and other alternative downstream cellular pathways, regulates circadian gene expression, which in turn may underlie the pathogenesis of mood disorders. Moreover, we summarize the convergent point of these signaling pathways and put forward a pattern by which Homer1a expression, regulated by both cAMP-response element binding protein (CREB) and circadian clock genes, may be the final common pathogenetic mechanism in depression.

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“…Disruptions of circadian rhythms in sleep/wake cycles, blood pressure, and hormonal secretion such as melatonin have been reported in patients with mood disorders. Clinical studies have pointed to a direct association between the severity of circadian rhythm disturbances and mood disorders and further showed a positive impact on mood disorders when restoring circadian dynamics with treatments ( Ruben et al, 2019 ; Sato et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

et al. 2022

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A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.

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Rapid-acting antidepressants and the circadian clock

Cited by 38 publications

References 222 publications

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

A Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

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