1976
DOI: 10.1097/00132586-197602000-00018
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Effects of Ketamine in Epilepsy

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Cited by 4 publications
(7 citation statements)
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“…The patterns of EEG activity obtained with ketamine in children correspond closely to those previously reported in cat, monkey, and adult man , CORSSEN et al 1974. Studies with depth electrodes indicate that ketamine excites neuronal activity in neocortex, hippocampus, and various subcortical structures (MORI et al 1971, KAYAMA & IWAMA 1972 corresponding to the periods of desynchronized I high frequency EEG activity.…”
Section: Discussionsupporting
confidence: 78%
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“…The patterns of EEG activity obtained with ketamine in children correspond closely to those previously reported in cat, monkey, and adult man , CORSSEN et al 1974. Studies with depth electrodes indicate that ketamine excites neuronal activity in neocortex, hippocampus, and various subcortical structures (MORI et al 1971, KAYAMA & IWAMA 1972 corresponding to the periods of desynchronized I high frequency EEG activity.…”
Section: Discussionsupporting
confidence: 78%
“…The observations of the excitatory action of ketamine caused some fear that the drug might induce and/or aggravate epileptic seizures (WINTERS 1972), and this seems to have been the case amongst some of the brain damaged epileptics studied by BENNETT et al (1973). Further studies on 17 and 26 epileptic patients, respectively (CORSSEN et al 1974, CELESIA et al 1975 clearly demonstrated that ketamine did not induce seizures, and that it was less effective than natural sleep in potentiating the electrographic epileptiform discharges. Furthermore, ketamine was shown actually to depress epileptogenic activity in penicillin foci in cat and monkey .…”
Section: Discussionmentioning
confidence: 99%
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“…If transient exposure to NMDAR antagonists during interictal activity resulted in depotentiation of synapses in epileptic foci and subsequent reductions in seizure probability (Staley and Dudek 2006, Dudek and Staley 2007), then epileptic patients exposed to NMDAR antagonists such as the anesthetic ketamine (Celesia et al 1975) or experimental anticonvulsants (Kohl and Dannhardt 2001), should have experienced long-term reductions in seizure probability. This has not been reported, but there are several reasons why NMDA antagonists may not have induced long-term depression at synapses generating periodic epileptic discharges.…”
Section: Discussionmentioning
confidence: 99%