Effects of Knee Debridement with Flurbiprofen on Knee Function, Inflammatory Levels, and Bone Metabolism Activity in Patients with Knee Osteoarthritis

Abstract

Objective. The objective of this study is to explore the effects of knee debridement with flurbiprofen on the knee function, inflammatory levels, and bone metabolism activity in patients with knee osteoarthritis. Methods. 110 patients with knee osteoarthritis who underwent arthroscopic debridement in our hospital from 2020.01 to 2022.01 were selected for retrospective analysis. Based on whether or not flurbiprofen was used in combination during the perioperative phase, the patients were divided into the control group (only arthroscopic debridement of the knee) and the research group (flurbiprofen with arthroscopic debridement of the knee), with 55 cases in each group. The indexes such as knee function, inflammatory levels, and bone metabolism activity of the two groups were analyzed. Results. According to hospital for special surgery (HSS) evaluation for knee function, most patients in the control group were assessed as “moderate,” while patients in the research group were mainly focused on “excellent” and “good,” and their excellent and good rates were remarkably higher than those in the control group ( P < 0.05 ). There were no significant variations in bone metabolism indices such as osteoprotegerin levels (OPG), insulin-like growth factor-1 (IGF-1), β-isomerized C-terminal telopeptide (β-CTX), and receptor activator of nuclear factor-κB ligand (RANKL) before treatment between both groups ( P > 0.05 ), with higher OPG, IGF-1 levels, and remarkably lower β-CTX, RANKL levels in the research group than those in the control group after treatment ( P < 0.05 ). There were no remarkable differences in pain between both groups before treatment ( P > 0.05 ), while at 24 h and 48 h after surgery, the VAS scores in the research group were remarkably lower than those in the control group ( P < 0.05 ). In terms of inflammatory factors, the levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2) in the research group were remarkably lower than those in the control group after treatment ( P < 0.05 ). Conclusion. Arthroscopy coupled with flurbiprofen provides a good analgesic effect in the therapeutic treatment of patients with knee osteoarthritis, which contributes to the recovery of knee function with definite results. Its mechanism may be associated with the control of inflammatory response and the regulation of bone metabolism disorder.

Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies

“…For most patients, conservative management is often piecemeal, and various interventions are tried as individual “one-offs” until something is found to offer relief. When such an intervention subsequently fails, the search continues until more invasive options are entertained; such options include pre-joint replacement surgical interventions such as osteotomies [ 81 ], drilling/microfracture of the bone [ 94 , 95 ], or debridement alone or in combination with other treatments [ 96 , 97 , 98 ]. While many of these invasive surgeries offer transient relief for a number of patients, they have not been evaluated for effectiveness regarding knee OA subsets as defined in this review.…”