Objective. The objective of this study is to explore the effects of knee debridement with flurbiprofen on the knee function, inflammatory levels, and bone metabolism activity in patients with knee osteoarthritis. Methods. 110 patients with knee osteoarthritis who underwent arthroscopic debridement in our hospital from 2020.01 to 2022.01 were selected for retrospective analysis. Based on whether or not flurbiprofen was used in combination during the perioperative phase, the patients were divided into the control group (only arthroscopic debridement of the knee) and the research group (flurbiprofen with arthroscopic debridement of the knee), with 55 cases in each group. The indexes such as knee function, inflammatory levels, and bone metabolism activity of the two groups were analyzed. Results. According to hospital for special surgery (HSS) evaluation for knee function, most patients in the control group were assessed as “moderate,” while patients in the research group were mainly focused on “excellent” and “good,” and their excellent and good rates were remarkably higher than those in the control group ( P < 0.05 ). There were no significant variations in bone metabolism indices such as osteoprotegerin levels (OPG), insulin-like growth factor-1 (IGF-1), β-isomerized C-terminal telopeptide (β-CTX), and receptor activator of nuclear factor-κB ligand (RANKL) before treatment between both groups ( P > 0.05 ), with higher OPG, IGF-1 levels, and remarkably lower β-CTX, RANKL levels in the research group than those in the control group after treatment ( P < 0.05 ). There were no remarkable differences in pain between both groups before treatment ( P > 0.05 ), while at 24 h and 48 h after surgery, the VAS scores in the research group were remarkably lower than those in the control group ( P < 0.05 ). In terms of inflammatory factors, the levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2) in the research group were remarkably lower than those in the control group after treatment ( P < 0.05 ). Conclusion. Arthroscopy coupled with flurbiprofen provides a good analgesic effect in the therapeutic treatment of patients with knee osteoarthritis, which contributes to the recovery of knee function with definite results. Its mechanism may be associated with the control of inflammatory response and the regulation of bone metabolism disorder.

Background: In our previous study, we have found that PPARγ-silenced BMSCs decreased adipogenic differentiation, but increased osteogenic differentiation after being induced by doxycycline. We demonstrated biphasic calcium phosphate (BCP) scaffold coated with multilayer of hydroxyapatite/poly-L-Lactide (HA/PLLA) nanocomposites is an excellent substitute for damaged and defect bone in bone tissue engineering. Combination of biomaterial scaffolds and therapeutic agents could contribute to a more predictable outcome with the potential of inducing bone formation while preventing bacterial infection. The delivery of BMSCs into Dox implant scaffolds aiming at enhancing the influence of BMSCs on the biocompatibility of the Dox implant has not been reported yet. Methods: The Poly-lactic-co-glycolic acid-Methoxypolyethylene glycols (PLGA-mPEG) microspheres were prepared by encapsulating the doxycycline, and they were incorporated into three dimensional BCP scaffold to build a doxycycline sustained release system of BCP scaffold. The preprocessed BCP scaffold is present to tBMSCs, then tBMSCs viability, tBMSCs proliferation and differentiation capacities are detected in vitro. Results: The microspheres were uniformly loaded on the BCP scaffolds and the pore structure was not affected, the BCP/Dox scaffolds were a good porous scaffold for the sustained release Dox for 2 months. The BCP/Dox scaffolds could promote transfected tBMSCs adhesion, proliferation and osteogenic differentiation in vitro. Conclusions: The BCP/Dox scaffold is a suitable carrier for localized delivery of the Dox, and he BCP/Dox scaffolds could promote adhesion, proliferation and osteogenic differentiation of undifferentiated tBMSCs in vitro, but more work is needed to research to meet the demands of tissue engineering.