Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of the male reproductive system

Jung, Sung-Jin; Kim, Hyeonjoong; Lee, Byung-Hwan; Choi, Sun-Hye; Kim, Hyun‐Sook; Choi, Yang‐Kyu; Kim, Joon Yong; Kim, Eun-Soo; Hwang, Sung‐Hee; Lim, Kwang Yong; Kim, Hyoung‐Chun; Jang, Minhee; Park, Seong Kyu; Cho, Ik‐Hyun; Nah, Seung-Yeol

doi:10.1016/j.jgr.2015.01.002

Cited by 44 publications

(33 citation statements)

References 18 publications

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“…22 Jung and colleagues reported that 40 mg/kg of busulfan caused injury to testicular tissue as well as reduction of sperm parameters and testosterone hormone. 23 Another study showed that busulfan administration caused a reduction in sperm parameters and glutathione peroxidase levels as well as increase in caspase 3 and MDA level. 24 Dehghani et al induced infertility rat model by injection of busulfan.…”

Section: Discussionmentioning

confidence: 99%

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice

Vafaei¹,

Mohammadi²,

Fazel³

et al. 2018

Pharm Sci

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Section: Discussionmentioning

confidence: 99%

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice

Vafaei¹,

Mohammadi²,

Fazel³

et al. 2018

Pharm Sci

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“…Three-week-old ICR male mice were given a single injection of 40 mg/kg body weight (BW) of busulfan. 37 The following day, the mice were dosed with ddH 2 O as the control or AOS 10 mg/kg BW via oral gavage (0.1 ml/mouse/day). Our preliminary experiments had found that 10 mg/kg was the best concentration for recovering the intestinal epithelial cell damage caused by busulfan.…”

Section: Materials and Methods [Detailed Methods In Supplemental Infomentioning

confidence: 99%

Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis

et al. 2020

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Worldwide the incidence of cancer has been continuing increasing. Mucositis of the gastrointestinal tract is a common side effect in patients under chemotherapy. Anticancer drug busulfan, used for treating chronic myeloid leukemia especially in pediatric patients, causes mucositis of the gastrointestinal tract. Alginate oligosaccharides (AOS) are natural products with attractive pharmaceutical potentials. We aimed to investigate, at the single-cell level, AOS preventing small intestine mucositis induced by busulfan. We found that busulfan disturbed the endoplasmic reticulum and mitochondria of cells in the small intestine, damaged cell membranes especially cell junctions, and disrupted microvilli; all of which were rescued by AOS. Single-cell RNA sequencing analysis and functional enrichment analysis showed that AOS could recover small intestinal function. Deep analysis found that AOS improved the expression of transcriptional factors which explained AOS regulating gene expression to improve small intestine function. Further investigation in IPEC-J2 cells found that AOS acts its function through mannose receptor signaling pathway. Moreover, the improved blood metabolome confirmed small intestinal function was recovered by AOS. As a natural product with many advantages, AOS could be developed to assist in the recovery of intestinal functions in patients undergoing anticancer chemotherapy or other treatments.

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“…The severity of dermatitis was assessed using the method described by Yamamoto et al 22) The severity of dermatitis was evaluated once, just before euthanization of the experimental animals. The development of (1) erythema/hemorrhage, (2) scarring/dryness, (3) edema, and (4) excoriation/erosion was evaluated using the following scoring system: 0 (none), 1 (mild), 2 (moderate), and 3 (severe).…”

Section: Evaluation Of Dermatitis Lesion and Ear Thicknessmentioning

confidence: 99%

Effects of Gintonin-Enriched Fraction in an Atopic Dermatitis Animal Model: Involvement of Autotaxin Regulation

Lee

Kim

Jang

et al. 2017

Biological & Pharmaceutical Bulletin

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Ginseng extract has been used for prevention of atopic dermatitis (AD) in experimental animal models. However, little is known about its active ingredients and the molecular mechanisms underlying its anti-AD effects. Recently, we isolated a unique lysophosphatidic acid (LPA) receptor ligand, gintonin, from ginseng. Gintonin, the glycolipoprotein fraction of ginseng, contains LPAs, mainly LPA C with other minor lysophospholipid components. A line of evidence showed that serum autotaxin (ATX) activity and level are significantly elevated in human AD patients compared to those in normal controls, which indicates that ATX may be involved in human AD. In a previous study, we demonstrated that gintonin exerted anti-inflammatory effects via inhibition of microglial activation and proinflammatory cytokine production by immune cells and that it strongly inhibited ATX activity. In this study, we investigated whether oral administration of the gintonin-enriched fraction (GEF) could ameliorate the symptoms of 2,4-dinitrofluorobenzene (DNFB)-induced AD in NC/Nga mice. We found that oral administration of GEF to DNFB-induced AD mice for 2 weeks reduced ear swelling and AD skin index. In addition, oral administration of GEF reduced the serum levels of immunoglobulin E, histamine, interleukin-4, and interferon-γ. Histological examination showed that oral administration of GEF attenuated skin inflammation and significantly reduced eosinophil and mast cell infiltration into the skin. Moreover, oral administration of GEF not only decreased serum ATX level but also reduced serum ATX activity. The present study shows that the anti-AD effects of ginseng might be attributed to GEF-induced anti-inflammatory activity and ATX regulation.

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Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of the male reproductive system

Cited by 44 publications

References 18 publications

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice

Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis

Effects of Gintonin-Enriched Fraction in an Atopic Dermatitis Animal Model: Involvement of Autotaxin Regulation

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