Effects of l-carnosine on splenic sympathetic nerve activity and tumor proliferation

Role of l-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine

“…Adrenal sympathetic nerve Suppression Decrease in adrenaline secretion (decreases in BP and BG) Yamano et al (2001) Hepatic sympathetic nerve Suppression Decreases in glycogenolysis and gluconeogenesis (decrease in BG) Yamano et al (2001) Pancreatic sympathetic nerve Suppression Increase in insulin secretion (decrease in BG) Niijima et al (unpublished data) Renal sympathetic nerve Suppression Decrease in BP Tanida et al (2005a, b) Brow adipose tissue sympathetic nerve Suppression Decrease in heat production (lowering of BT) Tanida et al (2007a) White adipose tissue sympathetic nerve Facilitation Increase in lipolysis Shen et al (2008) Splenic sympathetic nerve Suppression Increase in NK activity Horii et al (2012) BP blood pressure, BG blood glucose, BT body temperature, NK natural killer and the precise functions of CAR are important issues to be clarified in the near future. In parallel, we are interested in the effect of CAR on skeletal muscle sympathetic nerve activity, as sympathetic excitation in muscles causes dilatation of the muscle arterial vessels and increases the blood supply, and thus oxygen and nutrient supplies to muscles through the adrenergic b-2 receptor (Ganong 2005).…”

l-Carnosine’s dose-dependent effects on muscle sympathetic nerves and blood flow

“…In our previous work, evidence was found suggesting that CAR is released during physical exercise [4] and affects autonomic neurotransmission and physiological phenomena in a dose-dependent manner [5][6][7][8][9][10][11]. That is, CAR affects blood glucose, blood pressure, body temperature, lipolysis, and tumor immunity via changes in autonomic neurotransmission.…”

Oxaliplatin complexes with carnosine and its derivatives: in vitro cytotoxicity, mass spectrometric and computational studies with a focus on complex fragmentation

“…[41] More recently it has been reported that carnosine can prevent cell proliferation in colon cancer cells. [47,48] The related dipeptides N-acetlycarnosine and anserine share many of the beneficial characteristics of carnosine. The N-acetyled form of carnosine, N-acetyl-carnosine has been shown to be effective in the treatment of stomach ulcers [42] and similarly to carnosine has been used in the treatment of cataracts.…”