Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis

Chen, Chunlei; Li, Lanjuan; Wang, Zhongwen; Chen, Huguang; Fu, Shuzhen

doi:10.1016/j.jinf.2005.11.013

Cited by 51 publications

(34 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This could be because L. fermentum was present in the feces of the patients at the detection limit. These results confirmed the findings of the previous studies [7,10,13,26,36] and indicated that disturbance of gastrointestinal lactobacilli flora is associated with the liver injury. L. gasseri is closely related to L. acidophilus.…”

Section: Discussionsupporting

confidence: 92%

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Wang

Lü

et al. 2011

Microb Ecol

View full text Add to dashboard Cite

This study aims to provide an overview of the diversity of intestinal Lactobacillus among Chinese patients with hepatitis B virus (HBV)-related decompensated cirrhosis and who received liver transplant for hepatitis B cirrhosis. Fecal samples were collected from 38 healthy volunteers, 61 patients with HBV-related decompensated cirrhosis (group LC) and 74 patients who had liver transplant for hepatitis B cirrhosis (group LT). Quantitative polymerase chain reaction technology with species-specific primers was applied to investigate lactobacilli 16S rDNA in crude DNA, extracted from fecal samples. Software package Statistical Package for the Social Sciences and Palaeontological Statistics for Windows was used to analyze the data. Lactobacilli population of the two patient groups was different from the healthy control subjects, principal differences being marked decrease in the population of Lactobacillus rhamnosus (p < 0.001 for both patient groups) and reduction in the frequency of Lactobacillus fermentus (p < 0.001 for group LC and p < 0.01 for group LT). Our findings on the frequency of lactobacilli population suggested decreased diversity in groups LC and LT (compared with the healthy controls (p < 0.001 and p < 0.01, respectively)). Patients tended to have less complex fecal lactobacilli composition than the healthy controls, especially in the group LC.

show abstract

Section: Discussionsupporting

confidence: 92%

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Wang

Lü

et al. 2011

Microb Ecol

View full text Add to dashboard Cite

show abstract

“…Lactitol also acts as a prebiotic that is capable of promoting the growth of beneficial bacteria in the colon such as Bifidobacteria and Lactobacilli, but also reduces the population of putrefactive bacteria selectively and lowers the intestinal pH as well as the production and absorption of ammonia [45,46,48,50,51]. Lactitol was also applied in treating encephalopathy and constipation [52][53][54][55][56].…”

Section: Properties and Applicationsmentioning

confidence: 99%

“…Due to its properties, lactitol is used in certain pharmaceutical applications, in food for diabetics, low-calorie, low-fat and/or sugar-free foods such as ice cream, chocolate, hard and soft candies, baked goods, sugar-reduced preserves, chewing gums and sugar substitutes [49,52,57,58]. However, due to its low sweetness, it is usually mixed with intense sweeteners [47].…”

Section: Properties and Applicationsmentioning

confidence: 99%

Sugar alcohols—their role in the modern world of sweeteners: a review

Grembecka

2015

Eur Food Res Technol

346

296

View full text Add to dashboard Cite

observed. It was mainly due to the developments in biological studies, the change of a population lifestyle and the increase in the consumer awareness concerning food products. The health quality of food depends mainly on nutrients, but also on foreign substances such as food additives. The presence of foreign substances in the food can be justified, allowed or tolerated only when they are harmless to our health. Epidemic obesity and diabetes encouraged the growth of the artificial sweetener industry. There are more and more people who are trying to lose weight or keeping the weight off; therefore, sweeteners can be now found in almost all food products. There are two main types of sweeteners, i.e., nutritive and artificial ones. The latter does not provide calories and will not influence blood glucose; however, some of nutritive sweeteners such as sugar alcohols also characterize with lower blood glucose response and can be metabolized without insulin, being at the same time natural compounds. Sugar alcohols (polyols or polyhydric alcohols) are low digestible carbohydrates, which are obtained by substituting and aldehyde group with a hydroxyl one [1,2]. As most of sugar alcohols are produced from their corresponding aldose sugars, they are also called alditols [3]. Among sugar alcohols can be listed hydrogenated monosaccharides (sorbitol, mannitol), hydrogenated disaccharides (isomalt, maltitol, lactitol) and mixtures of hydrogenated mono-diand/or oligosaccharides (hydrogenated starch hydrolysates) [1,2,4].Polyols are naturally present in smaller quantities in fruits as well as in certain kinds of vegetables or mushrooms, and they are also regulated as either generally recognized as safe or food additives [5][6][7]. Food additives are substances that are added intentionally to foodstuffs in order to perform certain technological functions such as to give color, to sweeten or to help in food preservation.Abstract Epidemic obesity and diabetes encouraged the changes in population lifestyle and consumers' food products awareness. Food industry has responded people's demand by producing a number of energy-reduced products with sugar alcohols as sweeteners. These compounds are usually produced by a catalytic hydrogenation of carbohydrates, but they can be also found in nature in fruits, vegetables or mushrooms as well as in human organism. Due to their properties, sugar alcohols are widely used in food, beverage, confectionery and pharmaceutical industries throughout the world. They have found use as bulk sweeteners that promote dental health and exert prebiotic effect. They are added to foods as alternative sweeteners what might be helpful in the control of calories intake. Consumption of low-calorie foods by the worldwide population has dramatically increased, as well as health concerns associated with the consequent high intake of sweeteners. This review deals with the role of commonly used sugar alcohols such as erythritol, isomalt, lactitol, maltitol, mannitol, sorbitol and xylitol as sugar substitutes in food ...

show abstract

“…The gut-liver axis involves multiple inflammatory cells, cytokines, and other molecules which evoke immune response [5][6][7][8]. Clinical experiments also indicate amelioration of liver damage in viral hepatitis through improving intestinal microflora [9,10]. The importance of gut microbiota is observed in different types of chronic liver diseases, including hepatitis B.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota modulate the immune effect against hepatitis B virus infection

Huang

Wang

2015

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

The immunological mechanisms by which hepatitis B virus (HBV) initiates and maintains acute or chronic infection, even the formation of cirrhosis and hepatocellular carcinoma, are still undefined. An increasing number of studies have shown that intestinal flora regulate immune homeostasis, and, thus, protect the immunologic function against hepatitis virus infection. In this article, we discuss gut microbiota and its potential immune effects against HBV infection. It may provide a novel insight into the pathogenesis of HBV infection, as well as a potential therapeutic target to HBV-related disease.

show abstract

Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis

Cited by 51 publications

References 20 publications

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Assessment of the Fecal Lactobacilli Population in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis and Hepatitis B Cirrhosis Treated with Liver Transplant

Sugar alcohols—their role in the modern world of sweeteners: a review

Gut microbiota modulate the immune effect against hepatitis B virus infection

Contact Info

Product

Resources

About