Effects of Lactobacillus salivarius isolated from feces of fast-growing pigs on intestinal microbiota and morphology of suckling piglets

Abstract

The study determined the effects of Lactobacillus salivarius (LS) administered early in the life of suckling piglets on their growth performance, gut morphology, and gut microbiota. Thirty litters of 3-day-old crossbreed piglets were randomly assigned to one of the three treatments, and treatments were commenced on day 3 after birth. During the whole period of the experiment, the piglets were kept with their mothers and left to suckle ad libitum while being supplemented with a milk formula with or without the bacterial probiotic supplemented. The control group (CON) was not treated with probiotics, the HLS group was treated with LS144 (HLS) screened from feces of fast-growing pigs with high body mass index (BMI) while the NLS group was supplemented with LS160 (NLS) screened from feces obtained from pigs of normal BMI. At the weaning time, a higher abundance of Actinobacteria, Lentisphaerae, and Elusimicrobia phyla were observed in NLS piglets, whereas the abundance of Fibrobacteres phylum was significantly reduced in NLS and HLS piglets compared with the CON. A greater abundance of Lactobacillus was detected in the HLS treatment compared with the CON. The abundance of Bacteroides and Fibrobacter was higher in the CON piglets compared with the HLS and NLS piglets. Compared with the CON group, the oral administration of LS significantly increased the number of Lactobacillus and villus height in the duodenum, jejunum, and ileum. Moreover, the villus height of the duodenum was significantly improved in the HLS treatment compared with the NLS treatment. Based on the findings in the neonatal piglet model, we suggest that oral supplementation of LS, particularly LS isolated from high BMI pigs, could be beneficial by improving the intestinal villus height.

Supplementation of nano-zinc in lower doses as an alternative to pharmacological doses of ZnO in weanling pigs

“…Weaning is the most stressful time in a pig's life in modern swine farming and often causes diarrheic syndrome and growth depression [1][2][3]. At weaning, pigs are subjected to multiple stressors, including sudden dietary and environmental changes, that induce intestinal inflammation and unstable intestinal microbial communities [1,2,4].…”

Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges

“…Several probiotics have been found effective in improving animal performance and preventing diseases (Bajagai et al 2016). Certain L. salivarius strains have also antimicrobial activity in animals, preventing Salmonella enteritidis colonization in chicken (Pascual et al 1999;Lone et al 2021), and reducing and preventing enteropathogen infections in piglets (Kumar et al 2010;Zhou et al 2020;Moturi et al 2021) and calves (Maldonado et al 2018).…”

Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo

“…Therefore, the increase in relative abundance of Peptococcaceae caused by UA was consistent with the above and beneficial for mice. Normally, Clostridia species are considered pathogenic. , Clostridia may have an antagonistic relationship with Helicobacteraceae . Moreover, UA expands upon this result.…”

“…Normally, Clostridia species are considered pathogenic. 96,97 Clostridia may have an antagonistic relationship with Helicobacteraceae. Moreover, UA expands upon this result.…”