Effects of lanthanum in cellular systems

Das, Tarun; Sharma, Archana; Talukder, Geeta

doi:10.1007/bf02917504

Cited by 133 publications

(68 citation statements)

References 162 publications

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“…The concentration of La found in smelter's lungs was 2 to 16 times higher than in normal lungs (12); La, Ce, Nd, Sm, Eu, Tb, Yb, and Lu were found in a deceased photoengraver's lungs (13). These workers are at risk of pneumoconiosis; one worker, who had been exposed for only 18 months to dust containing 60% of RE (mainly Ce, La, and Nd), was reported to have radiologic evidence of pneumoconiosis (14).…”

Section: Exposure To Rare Earthsmentioning

confidence: 74%

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

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Section: Exposure To Rare Earthsmentioning

confidence: 74%

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

Hirano¹,

Suzuki²

1996

Environmental Health Perspectives

153

187

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“…The results showed the largest influence of Ce and La on viability and inflammatory response, followed by Pr and Nd. Especially the light REE La, Ce and Pr are known to be hepatotoxic by inducing fatty liver 17,48 . Pr is the most toxic element leading to animal death in comparable concentrations used for Ce, probably due to its low clearing rate 17 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

Feyerabend¹,

Fischer²,

Holtz³

et al. 2010

Acta Biomaterialia

532

263

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Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REE) are used to improve the mechanical properties of the alloys, however in more or less undefined mixtures. Therefore in this study the in vitro cytotoxicity of the elements yttrium (Y), neodymium (Nd), dysprosium (Dy), praseodymium (Pr), gadolinium (Gd), lanthanum (La), cerium (Ce), europium (Eu), lithium (Li), zirconium (Zr), was evaluated by incubation with the chlorides (10-2000 µM), magnesium (Mg) and calcium (Ca) were tested at higher concentrations (200 and 50 mM, respectively). The influence on viability of human osteosarcoma cell line MG-63, human umbilical cord perivascular (HUCPV) cells and mouse macrophages (RAW 264.7) was determined, as well as the induction of apoptosis and the expression of inflammatory factors (TNF-α, IL-1α). Significant differences between the applied cells could be observed. RAW exhibited the highest and HUCPV the lowest sensitivity. La and Ce showed the highest cytotoxicity of the analysed elements. From the elements with high solubility in magnesium alloys Gd and Dy seem to be more suitable than Y. The focus of magnesium alloy development for biomedical applications should include most defined alloy compositions with well known tissue specific and systemic effects.

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“…Metabolism and toxicity of REEs have been investigated to date by oral, intravenous, and intraperitoneal administration and instillation or intratracheal instillation in rats, dogs, mice, hamsters, and chicks (Durbin et al, 1956;Magnusson, 1963;Haley et al, 1964a,b;Sihvonen, 1972;Arvela, 1979, Das et al, 1988Evans, 1990;Hirano et al, 1996). Fatty liver was observed in female rats administered light REEs intravenously (Snyder et al, 1959(Snyder et al, , 1960; however, the differences between REEs in terms of behavior in vivo have not yet been clarified.…”

Section: O 1»»7 Society Oftoricologymentioning

confidence: 99%