Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells

Navarro-Moreno, L.G.; Escorza, Martha Angélica Quintanar; González, Silvia; Mondragón, Ricardo; Cerbón-Solórzano, Jorge; Valdés, J.; Calderón-Salinas, José-Víctor

doi:10.1016/j.tiv.2009.07.020

Cited by 78 publications

(43 citation statements)

References 29 publications

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“…Only 1 h after intestinal absorption, lead accumulates in bone, liver, kidney and other organs (Mansouri and Cauli, 2009;Navarro-Moreno et al, 2009). In many countries, including China, Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Few adverse health effects are observed after an acute exposure at middle or low-dose levels (Gautam and Flora, 2010), including neurological, behavioral, hematological, renal, hepatic, growth retardation, immunological and reproductive disfunctions (Bokara et al, 2008;El-Nekeety et al, 2009). The potential role of oxidative stress injury, which is associated with lead poisoning, suggests that antioxidants may enhance the efficacy of treatment designed to mitigate lead-induced toxicity (Yin et al, 2008;Navarro-Moreno et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Xia

Liao

et al. 2010

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Xia

Liao

et al. 2010

Journal of Ethnopharmacology

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“…Lead rapidly accumulates in liver, kidney and other human organs after intestinal absorption (Mansouri & Cauli, 2009;Navarro-Moreno et al, 2009). Many previous studies have suggested that Pb might induce undesirable complications in laboratory animals and humans, such as physiological, biochemical, neurological, behavioral and reproductive dysfunctions (Abdallah et al, 2010;Patrick, 2006).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Heidarian

Rafieian-Kopaei

2013

Pharmaceutical Biology

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Context: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it has antitoxic activity. Objective: Lead (Pb) is a dangerous environmental toxicant that induces a broad range of dysfunctions in human. This study evaluated the protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with lead-containing diet. Materials and methods: Thirty-two rats were randomly divided into four groups. The first (control) group received standard diet. The second, third and fourth groups received 500 mg lead/kg diet, 500 mg lead/kg diet plus 300 mg/kg b.w. artichoke extract daily, and 500 mg lead/ kg diet plus 1 mg vitamin C/100 g b.w. daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), malondialdehyde (MDA) and liver histopathology assessments were conducted. Results: Serum lead, triglyceride (TG), VLDL, ALT, AST, ALP and MDA levels decreased significantly (p50.05) in the artichoke-treated group (35.85, 38.26, 38.38, 21.90, 12.81, 26.86 and 46.91%, respectively) compared to lead-intoxicated rats without treatment. No significant change was observed in serum lead, ALP and ALT between artichoke and vitamin C-treated groups (p40.05). Furthermore, the liver histopathology in rats treated with artichoke showed a mild degree of lymphocyte infiltration that was relatively comparable to the control and vitamin C-treated groups. Discussion and conclusion: These results clearly show that the artichoke extract in lead-poisoned rats has suitable chelating properties for the reduction of blood lead levels.

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“…Lead (Pb), is widely used in developing countries in leaded gasoline, but also in the production of a wide range of products including lead-acid batteries, leaded crystal ware, printing dyes, hair colouring dyes, and cosmetics (Wozniak and Blasiak 2003). Pb toxicity includes, adverse eVects in the gastrointestinal tract, hematopoietic system, cardiovascular system, central and peripheral nervous systems, kidneys, immune system, and reproductive system (Navarro-Moreno et al 2009). To sum up, the eVects of environmental exposure to trace toxic metals such as Cd, W, Te, Be, and Pb could lead to many pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

Comparison of urine toxic metals concentrations in athletes and in sedentary subjects living in the same area of Extremadura (Spain)

et al. 2011

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Cadmium (Cd), tungsten (W), tellurium (Te), beryllium (Be), and lead (Pb), are non-essential metals pervasive in the human environment. Studies on athletes during training periods compared to non-training control subjects, indicate increased loss of minerals through sweat and urine. The aim of this study was to compare the level of these trace elements, determined by inductively coupled plasma mass spectrometry (ICP-MS) in urine samples, between athletes and age-matched sedentary subjects living in the same geographical area, although anthropometric and cardiovascular measurements showed that athletes have significantly (P ≤ 0.001) lower BMI, body fat and heart rate, whereas the muscle and bone percentage was significantly (P ≤ 0.001) higher than in sedentary subjects. The validity of the methodology was checked by the biological certified reference material. Trace element analysis concentrations, expressed in μg/mg creatinine, of five toxic elements in urine from athletes (n = 21) versus sedentary subjects, (n = 26) were as follows: Cd (0.123 ± 0.075 vs. 0.069 ± 0.041, P ≤ 0.05); W (0.082 ± 0.053 vs. < limit of detection); Te (0.244 ± 0.193 vs. 0.066 ± 0.045, P ≤ 0.001), Be (0.536 ± 0.244 vs. 0.066 ± 0.035, P ≤ 0.001); Pb (0.938 ± 0.664 vs. 2.162 ± 1.444 P ≤ 0.001). With the exception of Pb, urine toxic metal concentrations from athletes were higher than from sedentary subjects. This fact suggests that physical activity counteracts, at least in part, the cumulative effect of toxic environment by increasing the urine excretion of toxic metals in trained people.

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Effects of lead intoxication on intercellular junctions and biochemical alterations of the renal proximal tubule cells

Cited by 78 publications

References 29 publications

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Comparison of urine toxic metals concentrations in athletes and in sedentary subjects living in the same area of Extremadura (Spain)

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