Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus

Silva, L.L.; Gomes, Bruno da Silva; Sousa-Neto, Benedito P; Oliveira, J.P.C.; Ferreira, Éverton L. F.; Chaves, Mariana Helena; Oliveira, Francisco de Assis

doi:10.1016/j.jep.2011.10.023

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…Esses resultados estão em acordo com os dados fitoquímicos apresentados na literatura para a espécie. [15][16][17][18][19] Somente no extrato hexânico observou-se a formação de coloração verde na reação de Liebermann-Burchard, indicativo da presença de triterpenos e/ou esteroides. De acordo com Burke e colaboradores, 23 a mudança na coloração é devida a formação do carbocátion 3,5-colestadieno que absorve em torno de 410 nm.…”

Section: Triagem Fitoquímicaunclassified

“…A investigação fitoquímica dos extratos de baixa polaridade das folhas secas de L. pisonis, resultou na identificação da mistura dos triterpenos: epifriedelanol e friedelina (1+2), α-amirina e β-amirina (4+5) e esqualeno (3), da mistura dos esteroides: estigmasterol e β-sitosterol (6+7); α-tocoferol (8); e da mistura dos seguintes ésteres de cadeia longa: palmitato de metila, palmitato de etila, 9-octadecenoato de etila, 9,12,15-octadecanoato de metila, palmitato de butila, octadecanoato de etila e octadecanoato de butila (9)(10)(11)(12)(13)(14)(15). O fracionamento dos extratos de alta polaridade possibilitou a identificação do ácido ursólico (16) (21), ácido gálico (17) e do galato de metila (19). Do hidrolato resultante da extração das folhas frescas em destilador tipo Clevenger, foram identificados o ácido gálico (17) e o ácido elágico (18).…”

Section: Determinação Estrutural Das Substânciasunclassified

“…[11][12][13] Pesquisas sobre a composição química de L. pisonis revelaram a presença de triterpenos, esteroides, saponinas triterpênicas, diterpenos, ácidos fenólicos, flavonoides, álcoois, aldeídos e monoterpenos. [14][15][16][17][18][19] Estudos atribuem à composição química da espécie algumas atividades biológicas, tais como: citotóxica, contra três linhagens celulares de tumor humano, 15 antipruriginosa, 16 antioxidante, 17,[19][20][21] antinociceptiva 22 e anti-inflamatória. 20 Observando o potencial biológico de L. pisonis, este trabalho teve como objetivo realizar a prospecção fitoquímica dos extratos brutos em hexano, MeOH e MeOH:H 2 O das folhas de um espécime de L. pisonis.…”

Section: Introductionunclassified

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Phytochemical Profile and Antioxidant activity of a Lecythis pisonis Cambess. Specimen (Lecythidaceae)

Barreto¹,

Moreira²,

Gomes³

et al. 2020

Rev. Virtual Quim.

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The species Lecythis pisonis (L. pisonis) popularly known as "sapucaia" or "cumbuca de macaco", is a plant belonging to the family Lecythidaceae. This family has interesting pharmacological activities that have driven researchers to explore their species. Observing the biological potential of the species L. pisonis, this work aimed to trace the chemical profile of its leaves and to evaluate the in vitro antioxidant (DPPH and ABTS •+) and cytotoxic activity against Artemia salina Leach larvae. Qualitative tests identified the presence of triterpenes, steroids, saponins, flavonoids, and phenolics in general. The phytochemical investigation of the leaves resulted in the identification of the mixture of triterpenes: epifriedelanol and friedelin (1+2), α-amyrin and β-amyrin (4+5), squalene (3) and ursolic acid (16); the mixture of steroids: stigmasterol and β-sitosterol (6+7); α-tocopherol (8); of the mixture of esters: methyl palmitate, ethyl palmitate, ethyl 9-octadecenoate, 9,12,15-methyl octadecanoate, butyl palmitate, ethyl octadecanoate and butyl octadecanoate (9-15); the mixture of isoquercitrin and astragalin flavonoids (20+21); gallic acid and methyl gallate (17+19); gallic acid (17) and ellagic acid (18). This the first report of the identification of substances 8-15, 17-21 in the leaves of the species L. pisonis. The evaluation of the antioxidant activity of polar extracts revealed a great antioxidant potential, which may be associated with high levels of phenols and total flavonoids. The quantification of proanthocyanidin in the extract in MeOH showed a content of 8.65 mg EC/g of crude extract. The bioassay carried out with A. salina MeOH and MeOH:H 2 O extracts showed mild toxicity. A espécie Lecythis pisonis (L. pisonis), conhecida popularmente como sapucaia ou cumbuca de macaco, é uma planta pertencente à família Lecythidaceae. Esta família possui atividades farmacológicas interessantes que têm impulsionado pesquisadores a explorar suas espécies. Observando o potencial biológico da espécie L. pisonis, este trabalho teve como objetivo traçar o perfil químico de suas folhas, avaliar a atividade antioxidante in vitro (DPPH e ABTS •+) e citotóxica contra larvas de Artemia salina Leach. Os testes qualitativos identificaram a presença de triterpenos, esteroides, saponinas, flavonoides e outros compostos fenólicos. A investigação fitoquímica das folhas resultou na identificação da mistura de triterpenos: epifriedelanol e friedelina (1+2), α-amirina e β-amirina (4+5), esqualeno (3) e ácido ursólico (16); da mistura dos esteroides: estigmasterol e β-sitosterol (6+7); α-tocoferol (8); da mistura dos ésteres: palmitato de metila, palmitato de etila, 9-octadecenoato de etila, 9,12,15-octadecanoato de metila, palmitato de butila, octadecanoato de etila e octadecanoato de butila (9-15); da mistura dos flavonoides isoquercitrina e astragalina (20+21); do ácido gálico e galato de metila (17+19); do ácido gálico (17) e ácido elágico (18). Sendo este o primeiro relato da identificação das substâncias 8-15, 17-21 nas folh...

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Section: Triagem Fitoquímicaunclassified

Section: Determinação Estrutural Das Substânciasunclassified

Section: Introductionunclassified

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Phytochemical Profile and Antioxidant activity of a Lecythis pisonis Cambess. Specimen (Lecythidaceae)

Barreto¹,

Moreira²,

Gomes³

et al. 2020

Rev. Virtual Quim.

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“…Several parts of sapucaia plants such as the leaves, shell, and oil are also used in popular medicine (Agra, Freitas, & Barbosa-Filho, 2007;Franco & Barros, 2006;Wickens, 1995). The antipruritic effects and antinociceptive activity of Lecythis pisonis leaves have been reported (Brandão et al, 2013;Silva et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Sapucaia nut (Lecythis pisonis Cambess) and its by-products: A promising and underutilized source of bioactive compounds. Part II: Phenolic compounds profile

Demoliner

Policarpi

Vasconcelos

et al. 2018

Food Research International

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In this study, the profile of the bioactive compounds of sapucaia nut (Lecythis pisonis Cambess) and its by-products have been investigated. The phenolic profile by LC-ESI-MS/MS, the total phenolic content, the condensed tannins and the antioxidant activity of the sapucaia nut and shell were determined. 14 phenolic compounds were identified in the sapucaia nut extract, primarily phenolic acids and flavonoids. Catechin, epicatechin, myricetin, ellagic acid and ferulic acid presented significant correlation to the antioxidant activity. The sapucaia shell contained 22 phenolic compounds, 13 of which were quantified. The sapucaia shell extract showed a high content of total phenolic compounds, a high condensed tannins content, and high antioxidant activity. The higher antioxidant activity of the shell can be associated with a higher content of phenolics. Overall, it can be concluded that the sapucaia nut is a raw material rich in phenolic compounds that present high antioxidant activity. The nuts and the cake may be used as a promising raw material for the food industry, while the shells could be an alternative source of natural antioxidants. Further use in the cosmetics and pharmaceutical industry may also be envisaged.

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“…The phytochemical study of the leaves of this species led to the isolation of pentacyclic triterpenoids, phytol, sitosterol and stigmasterol (Oliveira et al, 2012). The ethanol extract and the mixture of ursolic and oleanolic acids obtained from the leaves demonstrated antipruritic and cytotoxic activities (Silva et al, 2012;Oliveira et al, 2012). Other studies also showed that ethanol extract, eterea fraction and mixture of ursolic and oleanolic acids from leaves of L. pisonis exhibited antinociceptive activity in models of acute pain in mice (Brandão et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical investigation and antioxidant activity of extracts of Lecythis pisonis Camb.

Ferreira¹,

Mascarenhas

Chaves

et al. 2014

J. Med. Plants Res.

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Phytochemical investigation of the ethanol extract of leaves, twigs and fruit shell of Lecythis pisonis Camb. revealed the presence of squalene, -e -amyrin, lupeol, 3-friedelinol, ursolic and oleanolic acids, (E)-phytol, sitosterol, stigmasterol, campesterol, quercetin-3-O-rutinoside and kaempferol-3-Orustinoside. Structural elucidation was achieved using ultraviolet (UV), nuclear magnetic resonance (NMR), and mass spectrometry. This is the first report of the occurrence of flavonoids, together with squalene, lupeol and campesterol in L. pisonis. The EtOH extract of the leaves showed high antioxidant activity, which can be associated in part with the high level of phenols and flavonoids.

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Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus

Abstract: These results clearly indicate the antipruritic effects of Lecythis pisonis leaves and suggest that this effect may be related to a stabilizing action on mast cell membrane. Furthermore, these data support the traditional use of this plant against cutaneous pruritus.

Cited by 14 publications

References 23 publications

Phytochemical Profile and Antioxidant activity of a Lecythis pisonis Cambess. Specimen (Lecythidaceae)

Phytochemical Profile and Antioxidant activity of a Lecythis pisonis Cambess. Specimen (Lecythidaceae)

Sapucaia nut (Lecythis pisonis Cambess) and its by-products: A promising and underutilized source of bioactive compounds. Part II: Phenolic compounds profile

Phytochemical investigation and antioxidant activity of extracts of Lecythis pisonis Camb.

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