Effects of Leptin on Intestinal Ischemia–Reperfusion Injury

Abstract

Many clinical conditions such as shock, sepsis,

Leptin and curcumin affect renal ischemia-reperfusion injury via modulation of P65 and Bax genes expression

“…Also TNF-α and NF-κB levels were both increased in the cisplatin-induced nephrotoxicity [22]. Moreover pretreatment with NF-κB inhibitor significantly decreased TNF-α gene expression [23] Interestingly our results revealed that leptin could attenuate nephrotoxic effects of I/R injury as it decreased MDA, NO and TNF-α and increased TCA in renal tissue, this is in agree with previous study which showed that leptin decreases intestinal IR injury [24]. Furthermore, leptin has been considered an important factor for treating brain ischemia/ reperfusion injury [25] as it has an anti inflammatory effect through inhibiting the expression of tumor necrosis factor (TNF) α, IL-6, IL-1β and increasing the expression of IL-10 [26].…”

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

“…A preliminary study was done to determine the effect of the vehicle, but there were insignificant differences between the non-treated OVIR group and the OVIR group treated with the vehicle. Both leptin doses (10 and 100 µg/kg) were selected based on the literature data (Erkasap et al 2004(Erkasap et al , 2017Sarsu et al 2015;Ragy and RaMzy 2021) indicating that these doses could improve oxidative stress, apoptosis, and inflammation associated with IR injuries. In addition, these doses are within the physiological range (Feng et al 2013;Pico et al 2021) because high leptin dose may suppress the ovarian functions (Shaikat et al 2021).…”

“…In several animal models of IR injuries, leptin decreased the severity of these injuries via its antioxidant, anti-apoptotic, and anti-inflammatory activities (Sarsu et al 2015;Zhang et al 2019;Ragy and RaMzy 2021). There are many studies demonstrating that agents with antioxidant or anti-inflammatory activities may be beneficial in reducing ovarian IR injury (Colak et al 2020;Ali et al 2021;Demir et al 2021).…”