Effects of Leukemia Inhibitory Factor on Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells

Zhou, Yi; Qian, Mingbo; Liang, Youde; Liu, Yi; Yang, Xu; Jiang, Tao

doi:10.1016/j.joen.2011.02.031

Cited by 20 publications

(19 citation statements)

References 29 publications

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“…In response to cytokines, STAT3 proteins are phosphorylated and form homo-or heterodimers, and translocate to the nucleus, where they act as transcription activators. The STAT3 signal pathway has been reported to be important for odontoblastic differentiation in MSCs by cytokines (34). We have observed that IFNG reduced the phosphorylation level of STAT3 and that this activity was STAT1-dependent.…”

Section: Ifng Is a Primary Checkpoint For Cytokine-induced Odontoblasticmentioning

confidence: 63%

Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

Zha

Bucher

Nejatfard

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Cytokines are protein mediators that are known to be involved in many biological processes, including cell growth, survival, inflammation, and development. To study their regulation, we generated a library of 209 different cytokines. This was used in a combinatorial format to study the effects of cytokines on each other, with particular reference to the control of differentiation. This study showed that IFN-γ is a master checkpoint regulator for many cytokines. It operates via an autocrine mechanism to elevate STAT1 and induce internalization of gp130, a common component of many heterodimeric cytokine receptors. This targeting of a receptor subunit that is common to all members of an otherwise diverse family solves the problem of how a master regulator can control so many diverse receptors. When one adds an autocrine mechanism, fine control at the level of individual cells is achieved.A s our understanding of physiology grows, we are increasingly aware of its Newtonian aspects in that for every action there is another reaction with opposite consequences (1). Irrespective of whether one thinks in terms of homeostasis, feedback loops, or checkpoints, we increasingly uncover molecular systems that, in terms of function, induce cells to move in opposite ways. For example, although immune T-cell activation is critical in controlling disease, one needs a checkpoint to guard against overactivity that could result in autoimmunity (2, 3).In addition to adding to our general knowledge of cellular physiology, detailed understanding of the molecular mechanisms of activation and checkpoint processes has important therapeutic implications. Such an understanding allows two separate entry points into the regulation of cellular events. Thus, if one wants to promote a cellular function, the same outcome can be achieved by either enhancing the effector or inhibiting the checkpoint pathways, usually by perturbing the molecules that initiate them.One of the most important physiological systems is the cytokine cascade (4). However, here, because the cascade contains large numbers of separate molecules, each operating through different receptors, simple models of regulation break down. While one can imagine that each cytokine is paired with a separate checkpoint system operating in an opposite direction, it seemed to us to be unlikely, if for no other reason than the economical use of genetic information. Given that one had large sets of related molecules with overlapping signal transduction mechanisms and pathways, it seemed more reasonable to assume that, depending on the circumstance, some members of the cytokine repertoire regulate other members of the repertoire. This differs from situations such as PD-1, where the checkpoint mechanistic cascade differs completely from the activation mechanism. By contrast, we propose that cytokine members of a family regulate each other by perturbing common molecular mechanisms. Thus, if gene action economy is proposed for a family, its hallmark should be that some of the same molecules used for...

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Section: Ifng Is a Primary Checkpoint For Cytokine-induced Odontoblasticmentioning

confidence: 63%

Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

Zha

Bucher

Nejatfard

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…31 Besides, investigations provide direct evidence that the Jak2-Stat3 signalling regulates odontoblastic differentiation of DPCs, but the underlying mechanism is still unclear. 32 This gene was repressed in undifferentiated pulp cells and induced in odontoblast-like cells. Fas receptor (TNF receptor superfamily member 6) presents several roles in apoptosis during odontogenesis and in cell proliferation of cervical loops.…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated pulp cells and odontoblast-like cells share genes involved in the process of odontogenesis

Ferreira

Dernowsek

Passos

et al. 2015

Archives of Oral Biology

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“…On sait que la pulpe contient des cellules souches capables de se différencier en odontoblastes, permettant ainsi la formation de dentine en cas de lésion carieuse. LIF et LIFR inhiberaient cette différenciation, essentielle pour la formation de dentine régénérative [12]. Ils favoriseraient alors le maintien « ouvert » des canaux dentinaires et leur colonisation bactérienne à l'origine de la pulpite.…”

Section: Discussionunclassified

Ulcérations buccales révélatrices d’une leucémie aiguë myéloïde de type 4

O'hana

Baudet-Pommel

Barthélémy

et al. 2015

Med Buccale Chir Buccale

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Résumé -Introduction :Les leucémies constituent un ensemble d'hémopathies malignes caractérisées par la prolifération de précurseurs des cellules sanguines appelés blastes. Elles sont classées en formes aiguës ou chroniques selon leur comportement clinique, et en type lymphoïde ou myéloïde, en fonction de leur origine histologique. Cette maladie peut survenir à tout âge, mais c'est après 40 ans que sa fréquence augmente, l'âge moyen du diagnostic étant de 65 ans. 25 % des cas sont diagnostiqués avant 25 ans ; les leucémies aiguës (notamment lymphoïdes) sont également la pathologie maligne la plus fréquemment rencontrée chez les moins de 15 ans. Des manifestations buccales sont retrouvées dans 95 % des cas pour les formes aiguës myéloïdes. Cette pathologie se traduit sur les plans clinique et biologique par la survenue d'une anémie, d'une neutropénie et d'une thrombopénie. Observation : Les manifestations buccales de notre cas reflètent toutes ces anomalies : pâleur des muqueuses, présence de pétéchies et d'une ulcération muqueuse probablement d'origine neutropénique. Discussion : Ce sont ces manifestations qui ont alerté l'équipe de soins et ont conduit à la prescription d'un bilan hématologique révélant la leucémie. Ceci montre qu'un simple examen attentif de la cavité buccale peut permettre de dépister une affection systémique sous-jacente.Abstract -Oral ulceration indicative of type 4 acute myeloid leukemia. Introduction: Leukemias are a group of malignancies characterized by proliferation of precursors of blood cells named blasts. They are classified into acute and chronic forms, depending on their clinical behavior, and lymphocytic or myeloid, depending on their histological origin. This disease can occur at any age, but the incidence of the disease increases especially after 40 years of age; the average age at diagnosis is 65. 25% of cases are diagnosed before age 25; acute leukemias (especially lymphoid) are also the malignant disease most commonly found in children under 15 years old. Oral manifestations are found in 95% of cases for acute myeloid forms. This condition is reflected in the clinical and laboratory plans by the development of anemia, neutropenia and thrombocytopenia. Observation: The oral manifestations observed in the case presented in this article reflect these anomalies, with pale mucous membranes, petechiae and mucosal ulceration of neutropenic origin. Discussion: These events alerted the care team and led to the prescription of hematological evaluation revealing leukemia. This shows that a careful examination of the oral cavity may indicate an underlying systemic disease.

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Effects of Leukemia Inhibitory Factor on Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells

Cited by 20 publications

References 29 publications

Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

Undifferentiated pulp cells and odontoblast-like cells share genes involved in the process of odontogenesis

Ulcérations buccales révélatrices d’une leucémie aiguë myéloïde de type 4

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