Effects of levosimendan on indocyanine green plasma disappearance rate and the gastric mucosal–arterial pCO₂ gradient in abdominal aortic aneurysm surgery

Abstract

Levosimendan favours gastric perfusion but appears not to have a major effect on total splanchnic perfusion in patients undergoing an elective aortic aneurysm operation.

A Review of Indocyanine Green Fluorescent Imaging in Surgery

“…A 0.25 mg/kg dose of ICG was injected through a central venous line of the pulmonary artery catheter at baseline, before and during aortic clamping, and postoperatively. Levosimendan did not have a significant effect on total splanchnic perfusion in patients undergoing an elective aortic aneurysm operation [147]. …”

The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

“…After abdominal aortic aneurysm surgery pCO 2 g-a was lower in the levosimendan group in comparison to placebo, but despite a higher cardiac output this was not a result of better regional splanchnic perfusion [84]. In an experimental setting attenuation of sepsis-induced cellular hypoxia was observed, but simultaneous SDF-imaging failed to detect changes in microvascular blood flow [85].…”

The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

“…In patients with sepsis-induced myocardial depression levosimendan in addition to NE plus dobutamine was superior to an incremental dose of dobutamine, with respect to p CO 2g-a , laser Doppler-measured gastric mucosal perfusion, arterial lactate levels and creatinine clearance, either as a direct effect or as result of improved cardiac output [83]. After abdominal aortic aneurysm surgery p CO 2 g-a was lower in the levosimendan group in comparison to placebo, but despite a higher cardiac output this was not a result of better regional splanchnic perfusion [84]. In an experimental setting attenuation of sepsis-induced cellular hypoxia was observed, but simultaneous SDF-imaging failed to detect changes in microvascular blood flow [85].…”