Effects of LHRH, FSH and Activin A on Follistatin Secretion from Cultured Rat Anterior Pituitary Cells.

Liu, Zhonc-Hui; Shintani, Yoshihiro; Sakamoto, Yuki; Harada, Kyoko; Zhang, Chenyu; Fujinaka, Yuichi; Abe, Masahiro; Goto, Tetsuya; Saito, Shiro

doi:10.1507/endocrj.43.321

Cited by 20 publications

(11 citation statements)

References 27 publications

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“…Homo-or hetero-dimerization of two inhibin  subunits (A and B) form three types of activins, activin A (AA), activin B (BB) and activin AB (AB). Activin A plays a critical role in many physiological processes, including regulation of secretion of follicle-stimulating hormone (FSH) from anterior pituitary, differentiation of erythroblasts and embryonic development (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

Wang

Yang

et al. 2009

Cell Mol Immunol

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Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor  (TGF-) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1 and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. Cellular & Molecular Immunology. 2009;6(2):129-133.

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Section: Discussionmentioning

confidence: 99%

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

Wang

Yang

et al. 2009

Cell Mol Immunol

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“…Activin A plays a critical role in many physiological processes, including regulation of secretion of folliclestimulating hormone (FSH) from anterior pituitary, differentiation of erythroblasts and embryonic development (22)(23)(24). Our previous studies have reported that activin A can promote inflammatory mediator NO production from mouse peritoneal macrophages in vitro and induce the activation of mouse macrophage cell line RAW264.7 cells directly (11,18), which suggest that activin A may contribute to macrophage activation in the early stage of inflammation.…”

Section: Discussionmentioning

confidence: 99%

A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo

et al. 2009

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Activin A, a multifunctional factor of the transforming growth factor-beta (TGF-) superfamily, is mainly produced by microglia and macrophages, and its anti-inflammatory and pro-inflammatory activities are both related to macrophage functions. However the direct effect of activin A on the rest macrophages in vivo remains unclear. In the present study, the results showed that activin A not only increased NO and IL-1 release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC I and MHC II expression. Moreover, we found that activin A significantly upregulated the expressions of CD14 and CD68, markers of mature macrophages, on the surface of macrophages in vitro and in vivo. These data suggest that activin A can induce primary macrophage maturation in vitro and in vivo, but may not trigger the acquired immune response via regulating expression of MHC molecules involved in presentation of antigen.

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“…Activin not only play an important role in regulating secretion of hor mone, but also ser ves as autocrine and paracrine factors to regulate the differentiation, p r o l i f e r a t i o n , a p o p t o s i s o f c e l l s a n d e m b r yo n i c development [17][18][19][20][21] . The latest studies have reported that as an important regulator, activin also has effects on inducing liver fibrosis, suppressing hepatocyte growth and so on [21][22][23][24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV

Zhou

Tai²,

Zhou³

et al. 2007

WJG

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AIM:To investigate the regulation of activin receptorinteracting protein 2 (ARIP2) expression and its possible relationships with collagen type Ⅳ (collagen Ⅳ) in mouse hepatoma cell line Hepal-6 cells. METHODS:The ARIP2 mRNA expression kinetics in Hepal-6 cells was detected by RT-PCR, and its regulation fa c t o r s w e re a n a l y ze d by t re a t m e n t w i t h s i g n a l transduction activators such as phorbol 12-myristate 13-acetate (PMA), forskolin and A23187. After pcDNA3-ARIP2 was transfected into Hepal-6 cells, the effects of ARIP2 overexpression on activin type Ⅱ receptor (ActRII) and collagen Ⅳ expression were evaluated. RESULTS:The expression levels of ARIP2 mRNA in Hapel-6 cells were elevated in time-dependent manner 12 h after treatment with activin A and endotoxin LPS, but not changed evidently in the early stage of stimulation (2 or 4 h). The ARIP2 mRNA expression was increased after stimulated with signal transduction activators such as PMA and forskolin in Hepal-6 cells, whereas decreased after treatment with A23187 (25.3% ± 5.7% vs 48.1% ± 3.6%, P < 0.01). ARIP2 overexpression could remarkably suppress the expression of ActRIIA mRNA in dose-dependent manner, but has no effect on ActRIIB in Hepal-6 cells induced by activin A. Furthermore, we have found that overexpression of ARIP2 could inhibit collagen Ⅳ mRNA and protein expressions induced by activin A in Hapel-6 cells. CONCLUSION:

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Effects of LHRH, FSH and Activin A on Follistatin Secretion from Cultured Rat Anterior Pituitary Cells.

Cited by 20 publications

References 27 publications

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo

Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV

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