Effects of light on aging and longevity

Shen, Jie; Tower, John

doi:10.1016/j.arr.2019.100913

Cited by 42 publications

(24 citation statements)

References 71 publications

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“…A number of studies have previously investigated the effects of light exposure on lifespan in Drosophila [41]. These studies, however, have not simultaneously examined the influence of diet and the influence of the photoreceptor cells.…”

Section: Supplemental Discussionmentioning

confidence: 99%

Dietary restriction andclockdelay eye aging to extend lifespan inD. melanogaster

Hodge

Meyerhof

Katewa

et al. 2021

Preprint

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Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in D. melanogaster by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage. Disrupting circadian rhythms in the eye by inhibiting the transcription factor, Clock (CLK), or CLK-output genes, accelerated visual senescence, induced a systemic immune response, and shortened lifespan. Flies subjected to dietary restriction were protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inactivation, achieved via mutating rhodopsin or housing flies in constant darkness, primarily extended lifespan in flies reared on a high-nutrient diet. Our findings establish the eye as a diet-sensitive modulator of lifespan and indicate that vision is an antagonistically pleiotropic process that contributes to organismal aging.

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Section: Supplemental Discussionmentioning

confidence: 99%

Dietary restriction andclockdelay eye aging to extend lifespan inD. melanogaster

Hodge

Meyerhof

Katewa

et al. 2021

Preprint

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“…The use of dimmed or turned off lights during sleep can have a positive effect on awake time or alertness being shorter, and making sleepiness faster [16]. Someone who is exposed to long duration of light at night will get sleep delays [17].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Sleep Quality of Breast Cancer Patients with Chemotherapy

Putri

Makiyah

2021

Open Access Maced J Med Sci

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BACKGROUND: Poor sleep quality becomes the effect of chemotherapy in breast cancer patients. AIM: This study aimed to examine the factors that influence breast cancer patients’ sleep quality undergoing chemotherapy. METHODS: This research used an observational method with cross-sectional design. There were 26 breast cancer patients undergoing chemotherapy at Djojonegoro Regional Hospital in Temanggung, Central Java. The characteristics of the respondent are recorded, including the demographic characteristics, respondents’ sleep quality, and the physiological status data of the respondent. The researchers use the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality. Data were analyzed using Kendall’s Tau and Spearman’s rank correlation test and the Pearson Product-Moment Correlation test. RESULTS: The result showed that breast cancer patients’ sleep quality is classified as poor with PSQI score of 10.96 ± 3.13. The average age of the respondent was 50.08 ± 7.31 years. The major characteristic of the respondent were 80.77% had married, 42.30% had elementary education, 61.54% did not work, and 61.54% had Rp 0, - income. Based on breast cancer patients undergoing chemotherapy, the respondents lived in rice field environment (42.30%), diagnosed with breast cancer <1 year (69.23%), had <1 year chemotherapy (96.15%), had under mastectomy on the left breast (80.76%), and underwent chemotherapy as much as 7.23 ± 4.80 times. Based on sleep quality, the respondents lived with nuclear family (61.54%), had no comorbidities (76.92%), did not consume other drugs (100%), did not consume sleeping pills (80.76%), and used lights during sleep (65.38%). There is a correlation between sleep quality and age and with whom the respondent lives in the same house. CONCLUSION: It was concluded that breast cancer patients undergoing chemotherapy had poor sleep quality, and the factors related to sleep quality were age and with whom the respondent lived in the same house.

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“…Light-induced damage has been widely used as a model system to study retinal degeneration [ 274 ], whereby prolonged and/or raised light exposure causes retinal oxidative stress [ 20 , 43 , 275 , 276 , 277 , 278 , 279 ]. In this sense, Chen et al, 2004 [ 280 ] analyzed the gene expression profile following light-induced retinal damage in a mouse model.…”

Section: Metallothionein Antioxidant Systemmentioning

confidence: 99%

Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

et al. 2021

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The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed.

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Effects of light on aging and longevity

Cited by 42 publications

References 71 publications

Dietary restriction andclockdelay eye aging to extend lifespan inD. melanogaster

Dietary restriction andclockdelay eye aging to extend lifespan inD. melanogaster

Factors Affecting Sleep Quality of Breast Cancer Patients with Chemotherapy

Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

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