Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

Özkan, Gülay; Kostka, Tina; Esatbeyoglu, Tuba; Capanoglu, Esra

doi:10.3390/molecules25235545

Cited by 75 publications

(39 citation statements)

References 119 publications

(183 reference statements)

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“…A previous study of isorhamnetin, an O-methylated quercetin glycoside abundant in onions, suggested that the glucose component in the quercetin glucoside affects its bioavailability [ 22 ]. The application of quercetin is also limited due to stability and solubility issues [ 23 ]. In this study, quercetin solubility and bioavailability were optimized by dissolving in alcohol to a molecular form before dispersing on the dry ingredients.…”

Section: Resultsmentioning

confidence: 99%

Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets

Tan

Tam

Rolston³

et al. 2021

Antioxidants

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Quercetin is a flavonoid that has been shown to have health-promoting capacities due to its potent antioxidant activity. However, the effect of chronic intake of quercetin on the gut microbiome and diabetes-related biomarkers remains unclear. Male C57BL/6J mice were fed HF or HF supplemented with 0.05% quercetin (HFQ) for 6 weeks. Diabetes-related biomarkers in blood were determined in mice fed high-fat (HF) diets supplemented with quercetin. Mice fed the HFQ diet gained less body, liver, and adipose weight, while liver lipid and blood glucose levels were also lowered. Diabetes-related plasma biomarkers insulin, leptin, resistin, and glucagon were significantly reduced by quercetin supplementation. In feces, quercetin supplementation significantly increased the relative abundance of Akkermansia and decreased the Firmicutes/Bacteroidetes ratio. The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation. These results indicated that diabetes biomarkers are associated with early metabolic changes accompanying obesity, and quercetin may ameliorate insulin resistance.

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Section: Resultsmentioning

confidence: 99%

Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets

Tan

Tam

Rolston³

et al. 2021

Antioxidants

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“…In this situation, the negative charge of the Cur-RL-Lips surface has been fully shielded by the CS with positive charge. As the Cur-RL-Lips surface becomes fully covered with CS, the surface charge of the liposomes becomes positive and the repulsion among the CS-coated liposomes dominates [ 3 ].…”

Section: Resultsmentioning

confidence: 99%

“…Liposomes (Lips) are spherically shaped vesicles consisting of a phospholipid bilayer that surrounds an aqueous core; they have attracted widespread attention for their good nutraceutical-loaded property [ 1 ]. Due to their phospholipid bilayer, liposomes are often used for encapsulating both hydrophilic and lipophilic functional ingredients and controlling their release [ 2 , 3 ]. Therefore, they have considerable potential for application in various fields such as functional foods, nutraceutical supplements, and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

The Formation of Chitosan-Coated Rhamnolipid Liposomes Containing Curcumin: Stability and In Vitro Digestion

et al. 2021

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There is growing interest in developing biomaterial-coated liposome delivery systems to improve the stability and bioavailability of curcumin, which is a hydrophobic nutraceutical claimed to have several health benefits. The curcumin-loaded rhamnolipid liposomes (Cur-RL-Lips) were fabricated from rhamnolipid and phospholipids, and then chitosan (CS) covered the surface of Cur-RL-Lips by electrostatic interaction to form CS-coated Cur-RL-Lips. The influence of CS concentration on the physical stability and digestion of the liposomes was investigated. The CS-coated Cur-RL-Lips with RL:CS = 1:1 have a relatively small size (412.9 nm) and positive charge (19.7 mV). The CS-coated Cur-RL-Lips remained stable from pH 2 to 5 at room temperature and can effectively slow the degradation of curcumin at 80 °C; however, they were highly unstable to salt addition. In addition, compared with Cur-RL-Lips, the bioavailability of curcumin in CS-coated Cur-RL-Lips was relatively high due to its high transformation in gastrointestinal tract. These results may facilitate the design of a more efficacious liposomal delivery system that enhances the stability and bioavailability of curcumin in nutraceutical-loaded functional foods and beverages.

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“…Encapsulation improves the solubilization of hydrophobic functional compounds, protecting them against oxidation and gastrointestinal tract chemical modifications, increasing their bioavailability [ 122 ]. Polyphenols are good candidates to be transported in NEs due to their good lipophilicity and their inherent stability limitations and water insolubility as well as their low bioaccessibility and bioavailability, which can be resolved by lipid encapsulation [ 123 ].…”

Section: Brief Overview Of Nano-encapsulated Polyphenols: Nature and Physiochemical Polymer Benefitsmentioning

confidence: 99%

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

et al. 2021

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Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance.

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Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

Cited by 75 publications

References 119 publications

Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets

Quercetin Ameliorates Insulin Resistance and Restores Gut Microbiome in Mice on High-Fat Diets

The Formation of Chitosan-Coated Rhamnolipid Liposomes Containing Curcumin: Stability and In Vitro Digestion

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

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