Effects of lipid chain length on the surface properties of alkylaminomethyl rutin and of its mixture with model lecithin membrane

He, Fang; Lin, Yi; Li, Ruixia; Tang, Guiqian; Wu, Dongfang

doi:10.1016/j.colsurfb.2011.05.017

Cited by 5 publications

References 32 publications

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Structurally Stable Attractive Nanoscale Emulsions with Dipole–Dipole Interaction‐Driven Interdrop Percolation

Shin

Gong

Cuadrado

et al. 2017

Chemistry A European J

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This study introduces an extremely stable attractive nanoscale emulsion fluid, in which the amphiphilic block copolymer, poly(ethylene oxide)-block-poly(ϵ-caprolactone) (PEO-b-PCL), is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO-b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface, which is systematically confirmed by T relaxation and DSC analyses. Moreover, suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops that exhibit no signs of coalescence or phase separation. This unique rheological behavior is attributed to the dipolar interaction between the phosphorylcholine groups of lecithin and the methoxy end groups of PEO-b-PCL. Finally, the nanoemulsion system significantly enhances transdermal delivery efficiency due to its favorable attraction to the skin, as well as high diffusivity of the nanoscale emulsion drops.

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