Effects of Lipidium sativum seeds extract (Garden cress) on the kidney in sodium nitrite receiving rats

Abstract

This study was carried out to investigate the modulating effect of Lipidium sativum (LS) seeds aqueous extract consumption against sodium nitrite (SN) that induced the nephrotoxicity in male rats. Rats were divided into four groups. Group 1 (control): without any treatment; group 2: injected with a single dose of SN (50 mg/kg body weight) 24 h prior to decapitation intraperitoneally (i.p.); group 3: given orally 300 mg/kg body weight of LS for four weeks; group 4: treated orally with LS for four weeks, then injected with a single dose of SN, at 24 h prior to decapitation (i.p.) with the same doses. The results showed that, the treatment with sodium nitrite revealed a significantly increase in the levels of sodium, chloride, total calcium, ionized calcium, urea, creatinine and uric acid comparing to the control group. In respect to serum potassium, there is a significant decrease when compared to the control group. Also, the kidney tissue thiobarbituric acid reactive substances (TBARS) were significantly increased. But the superoxide dismutase (SOD), glutathione (GSH) and Catalase (CAT) enzymes were markedly decreased. The pre-treatment with LS before the injection of SN improved the harmful effects of SN caused in the serum levels of the biochemical parameters tested and the concentrations of GSH, SOD, CAT and TBARS in the kidney tissue comparing to SN-treated rats. It could be concluded that Lipidium sativum seeds act as a natural substance for ameliorating the alterations in serum electrolytes, kidney function and oxidative damage induced by sodium nitrite in the kidney tissue.

Reproductive performance and milk yield of rabbits fed diets supplemented with garden cress (Lepidium sativum) seed

“…In agreement with this finding, Al Hamedan 42 demonstrated that GC seeds suppressed urea and creatinine levels, reducing the risk of acute kidney failure in rats 9 , 10 . This improvement in renal function was due to the active compounds in GC seeds, such as flavonoids and steroidal compounds, as demonstrated in this study, which increase glomerular filtration rate 43 . Moreover, GC seed also has nephroprotective and curative activities 42 .…”

“…Moreover, GC seed also has nephroprotective and curative activities 42 . A previous study reported the ability of GC seeds' aqueous extract to improve the kidneys and restore electrolyte balance and renal functions in sodium nitrite-treated rats 43 . However, flavonoids and phenolic compounds of GC could protect against diabetic nephropathy in streptozotocin-induced diabetic rats, which improved blood urea nitrogen, creatinine, and urine extraction and kidney tissue damage, with a reduction in mitochondrial damage 44 .…”

The Application of Dietary Wheat/Barley Alternative with Addition Cress Seeds Powder to Albino Rats

“…They were kept in cages filled with aspen shavings which was changed once to twice a week. The treatment started after one week for twenty-one days, first group fed a standard diet with wheat, second group replaced all wheat with barley, third group fed an equal amount of wheat and barley, fourth and fifth group study the effect of adding 5% Cress seeds with either wheat/ barley with the standard ratio as shown in table (1).…”