Effects of Lipopolysaccharide on the Recruitment of T Cells in the Seminal Tract of Roosters

Zhang, Ming; Isobe, Naoki; Yoshimura, Y.

doi:10.2141/jpsa.0120081

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Although the population of B cells is relatively low, probably to avoid the induction of antisperm antibody (Yoshimura et al, 2004;Zhang et al, 2013). We demonstrated the expression of nine AvBDs including AvBD3 to -5, -7 and -9 to -13 in the testis, and 10 AvBDs including AvBD1 to -5, -7 and -9 to -12 in the epididymis (Watanabe et al, 2011).…”

Section: Avian β-Defensinsmentioning

confidence: 83%

Innate Immune Functions in hen Reproductive Organs

Yoshimura

Mageed

Nii

et al. 2014

Avian Biology Research

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The ovary and oviduct of the hen are susceptible to various pathogenic microorganisms, and infections in these organs may not only contaminate the eggs, but also disorder the egg formation. The immune function of the ovary and oviduct is essential to protect these tissues from infection as well as for the production of hygienic eggs. This paper reviews recent studies on the host defence system in the reproductive organs with reference to their innate immune functions, with emphasis on the important role of Toll-like receptors and avian β-defensins in this defence system.

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Section: Avian β-Defensinsmentioning

confidence: 83%

Innate Immune Functions in hen Reproductive Organs

Yoshimura

Mageed

Nii

et al. 2014

Avian Biology Research

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Effects of sexual maturation and Salmonella infection on the expression of avian β-defensin genes in the chicken testis

2014

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Rooster infertility is a major concern in the poultry industry and protection of the male reproductive organs from pathogens is an essential aspect of reproductive physiology. During the last years, research on antimicrobial protection has elucidated the critical role of the antimicrobial peptides avian β-defensins (AvBDs) in the innate immunity in chickens. AvBDs have been reported to be expressed in the hen reproductive organs, providing protection against microbial pathogens including Salmonella Enteritidis (SE). However, mechanisms of antimicrobial protection of rooster reproductive organs and especially the testis, mediated by AvBDs are poorly understood. The aim of this study was to investigate the expression of the complete family of the 14 AvBD genes, in the rooster testis in vivo, to determine whether sexual maturation affects their testicular mRNA abundance and to investigate whether SE infection alters their expression. Expression analysis revealed that 9 members of the AvBD family, namely AvBD1, 2, 4, 5, 6, 9, 10, 12 and 14 were expressed in the testis. Quantitative real-time PCR analysis revealed that the mRNA abundance of three AvBDs was up regulated and of three AvBDs was down regulated with respect to sexual maturation. In addition, SE infection resulted in a significant induction of AvBD4, 10, 12 and 14 in the testis of sexually mature roosters. These findings provide strong evidence to suggest that an AvBD-mediated immune response mechanism exists in the rooster testis providing protection against bacterial pathogens including Salmonella species.

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Effects of different doses lipopolysaccharides on the mucosal barrier in mouse intestine

Zhou

et al. 2020

Research in Veterinary Science

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Effects of Lipopolysaccharide on the Recruitment of T Cells in the Seminal Tract of Roosters

Cited by 3 publications

References 27 publications

Innate Immune Functions in hen Reproductive Organs

Innate Immune Functions in hen Reproductive Organs

Effects of sexual maturation and Salmonella infection on the expression of avian β-defensin genes in the chicken testis

Effects of different doses lipopolysaccharides on the mucosal barrier in mouse intestine

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