2007
DOI: 10.1097/jcp.0b013e31815a23c2
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Effects of Lithium on Brain Glucose Metabolism in Healthy Men

Abstract: Lithium is clinically available for the treatment of mood disorders. However, it has remained unclear how lithium acts on the brain to produce its effects. The aim of this study was to evaluate the effects of chronic lithium on human brain activity using positron emission tomography and clarify the correlation between brain activity changes and cognitive functional changes as induced by chronic lithium administration. A total of 20 healthy male subjects (mean age, 32 +/- 6 years) underwent positron emission to… Show more

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Cited by 15 publications
(9 citation statements)
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“…However, only two patients were on lithium at the time of scanning and the results were unchanged in the analysis with exclusion of these two patients. Moreover, lithium related changes in brain activity have been reported for the dorsomedial frontal cortex, cerebellum and lingual cortex [41], but not for any region observed to correlate with psychometric data in our study. As regards verapamil, no verapamil-induced changes in brain metabolism have been reported thus far in the literature.…”
Section: Discussioncontrasting
confidence: 88%
“…However, only two patients were on lithium at the time of scanning and the results were unchanged in the analysis with exclusion of these two patients. Moreover, lithium related changes in brain activity have been reported for the dorsomedial frontal cortex, cerebellum and lingual cortex [41], but not for any region observed to correlate with psychometric data in our study. As regards verapamil, no verapamil-induced changes in brain metabolism have been reported thus far in the literature.…”
Section: Discussioncontrasting
confidence: 88%
“… 46 48 Finding that lithium alters T1ρ in the cerebellum adds to this evidence and is consistent with our interpretation that abnormal metabolism underlies the observed T1ρ abnormalities. Lithium is unlikely to reverse cellular loss but it has been suggested to change glucose consumption in the cerebellum, 49 , 50 perhaps through its effects on glycogen synthase kinase-3 or calcium signaling. 51 …”
Section: Discussionmentioning
confidence: 99%
“…Research across several diagnostic groups suggest pharmacotherapy may modify regional brain activity and volume (Arce et al, 2008; Bell et al, 2005; Foland et al, 2008b; Greicius et al, 2008; Hollander et al, 2008; Kohno et al, 2007; Moresco et al, 2001). Although it is possible medication may have contributed to these findings, previous observations that pharmacotherapy can reduce vPFC and amygdala abnormalities in mood disorders suggest inclusion of medicated subjects might have reduced group differences (Anand et al, 2007; Anand et al, 2005; Blumberg et al, 2005; Chen et al, 2008; Dougherty and Rauch, 2007; Jogia et al, 2008; Lawrence et al, 2004; Ozerdem et al, 2008; Yurgelun-Todd et al, 2000).…”
Section: Discussionmentioning
confidence: 99%