Effects of live attenuated and killed Salmonella vaccine on T-lymphocyte mediated immunity in laying hens

Babu, Uma S.; Scott, Michael L.; Myers, Michael J.; Okamura, Masashi; Gaines, Dennis; Yancy, Haile F.; Lillehoj, Hyun S.; Heckert, Robert A.; Raybourne, Richard B.

doi:10.1016/s0165-2427(02)00265-9

Cited by 66 publications

(30 citation statements)

References 30 publications

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“…Killed vaccines may also be destroyed rapidly and eliminated from the host, F o r P e e r R e v i e w O n l y 12 they may be poorly, immunogenic in unprimed hosts and unable to induce cytotoxic T cells (Nagaraja & Rajashekara, 1999). Live vaccines have been shown to be more effective in increasing lymphocyte proliferation in response to S. Enteritidis antigens in laying hens (Babu et al, 2003). They also have additional protective effects, particularly when administered orally, which can be exploited during their development and application.…”

Section: Live Versus Killed Vaccinesmentioning

confidence: 99%

Salmonella infections: immune and non-immune protection with vaccines

Barrow

2007

Avian Pathology

137

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Section: Live Versus Killed Vaccinesmentioning

confidence: 99%

Salmonella infections: immune and non-immune protection with vaccines

Barrow

2007

Avian Pathology

137

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“…In this context, comprehensive knowledge of immunological defense mechanisms of chickens against Salmonella exposure represents a crucial prerequisite for successful vaccine development. The immune-stimulating properties of various Salmonella vaccine preparations have already been examined for their potential to enhance antibody production, cell-mediated immunity, and induction of invasion of different cell populations in several organs or peripheral blood (3,8,9,13,23,24,39). Notably, T-cell reactions and cellular immune responses seem to be of central importance for defense against Salmonella infections in chickens (8,9,23,24).…”

Section: T Cells In the Spleen After Salmonella Immunization After Imentioning

confidence: 99%

Circulating γδ T Cells in Response toSalmonellaentericaSerovar Enteritidis Exposure in Chickens

Berndt¹,

Pieper

Methner

2006

Infect Immun

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“…Immediately prior to clearance of primary infection significant increases in the levels of mRNA encoding interleukin-1␤ (IL-1␤), gamma interferon (IFN-␥), and transforming growth factor ␤ (TGF-␤) were observed. Increases in ex vivo proliferation of splenocytes following stimulation with flagella and outer membrane proteins have been demonstrated in chickens infected with heat-killed or attenuated vaccine strains (2,3,36).…”

mentioning

confidence: 99%

A Strong Antigen-Specific T-Cell Response Is Associated with Age and Genetically Dependent Resistance to Avian Enteric Salmonellosis

Beal¹,

Powers²,

Wigley³

et al. 2005

Infect Immun

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Chicken genetics and age affect resistance to enteric infection with Salmonella enterica serovar Typhimurium and were used to identify the immune responses that may contribute to rapid clearance. When birds were infected at 40 days of age, line 6 1 chickens cleared the infection more effectively than line N chickens, whereas when birds were infected at 10 days of age, both chicken lines were highly susceptible to infection. Antibody levels, T-cell responsiveness, and cytokine mRNA levels were all elevated during infection. A negative correlation between resistance and antigen-specific antibody production was observed in older chickens. However, this finding was not replicated for age-related resistance; we found that older chickens exhibited a stronger and more rapid antibody response than younger chickens. The levels of interleukin-1␤ (IL-1␤) and gamma interferon (IFN-␥) mRNA were similar in the spleens and cecal tonsils of both line 6 1 and line N chickens, except for higher levels of IL-1␤ in the spleens of line 6 1 chickens at 6 days postinfection. Differences in the levels of IFN-␥ and IL-1␤ 1␤ mRNA between the lines were more apparent in younger chickens, but while the increases were greater than those observed in the older chickens, the clearance of enteric S. enterica serovar Typhimurium was much slower. The level of antigen-specific proliferation of splenocytes was associated with increased resistance in both experimental systems, and the strongest responses were observed in older and genetically resistant chickens. The data presented here implicate T-cell responses in the clearance of S. enterica serovar Typhimurium from the intestine of infected chickens.

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Effects of live attenuated and killed Salmonella vaccine on T-lymphocyte mediated immunity in laying hens

Cited by 66 publications

References 30 publications

Salmonella infections: immune and non-immune protection with vaccines

Salmonella infections: immune and non-immune protection with vaccines

Circulating γδ T Cells in Response toSalmonellaentericaSerovar Enteritidis Exposure in Chickens

A Strong Antigen-Specific T-Cell Response Is Associated with Age and Genetically Dependent Resistance to Avian Enteric Salmonellosis

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