Effects of Lizhong Tang on gastrointestinal motility in mice

Abstract

AIMTo investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.METHODSThe in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).RESULTSIn normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.CONCLUSIONThese results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

Network Pharmacological Analysis and Experimental Validation of the Effect of Smilacis Glabrae Rhixoma on Gastrointestinal Motility Disorder

“…Research on gastrointestinal motility abnormalities in traditional medicine has been actively conducted [ 31 ]. It was found that the possibility of controlling gastrointestinal movement and reduced gastrointestinal movement increased due to various traditional medicines, such as Pyungwi-san [ 32 ], Lizhong Tang [ 33 ], Poncirus trifoliate fruit [ 34 ], So-Cheong-Ryong-Tang [ 35 ], San-Huang-Xie-Xin-tang [ 36 ], Schisandra chinensis [ 37 ], Ge-Gen-Tang [ 38 ], Liriope Platyphylla Wang Et tang [ 39 ], Hwangryunhaedok-tang [ 40 ], Gamisoyo-San [ 41 ], Banhasasim-Tang [ 42 ], and Pinellia ternata Breitenbach [ 43 ]. In order for the oriental medical approach to become an efficient approach in controlling gastrointestinal motility, large-scale clinical studies are needed to prove the reproducibility and validity of the effects.…”

Differential Inhibition of the Rhythm and Amplitude of Acetylcholine-Dependent Contraction in the Murine Jejunum and Ileum &lt;i&gt;In Vitro&lt;/i&gt; by Thiamin and Quinine

“…This study suggested the functional interaction between Qui and β3-adrenoceptors, although it warrants further investigation. Recent studies on herbal medicines, such as Lizhong Tang and Dangkwisoo-san, reported that these modify the gastrointestinal motility or pacemaker activities of ICCs [30,31]. In addition, some herbal extracts of the roots of ginger and Liriope Platyphylla Wang et Tang have been reported to mediate the contraction of the ileal smooth muscle in rats [32,33].…”

Yeokwisan, a Standardized Herbal Formula, Enhances Gastric Emptying via Modulation of the Ghrelin Pathway in a Loperamide-induced Functional Dyspepsia Mouse Model

“…To measure the area of the stomach, all the stomachs were photographed, and then, the area of the stomach was calculated by ImageJ (NIH). In the experiments to determine gastric emptying, the choice of the phenol red solution volume and time point at which approximately 60% delayed gastric emptying was observed were established by our pilot experiment data ( Supplementary Figure S1 ) and other protocols ( Asano et al, 2016 ; Lee et al, 2016 ).…”