Effects of Loading Conditions on Articular Cartilage in a Metal‐on‐Cartilage Pairing

Stotter, Christoph; Stojanović, B.; Bauer, Christoph; Ripoll, Manel Rodríguez; Franek, F.; Klestil, Thomas; Nehrer, Stefan

doi:10.1002/jor.24426

Cited by 14 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the components of SF, the protein albumin, the linear polysaccharide hyaluronic acid (HA), a mucin-like glycoprotein named lubricin, also known as proteoglycan 4 (PRG4) and surface-active phospholipids (SAPL) like 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) are the main components believed to be responsible in joint lubrication [1], [2], [4], [9]. In addition, friction depends on the properties of the contacting interface materials [10]- [12]. Necas et al (2018) found that the addition of albumin and ϒ-globulin to the lubricant reduced friction in hard-onhard pairs, but had no substantial influence on hard-on-soft pairs [13].…”

Section: Introductionmentioning

confidence: 99%

Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulation

Damen

Donkelaar

Cardinaels

et al. 2021

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulation

Damen

Donkelaar

Cardinaels

et al. 2021

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…Recently, our study group reported the occurrence of biotribocorrosion in CoCr implants articulating against articular cartilage, 9 which was enhanced with frictional loading. 10 Considering the fact that CoCr ions release could be a crucial factor in progressive degeneration of articular cartilage, human osteoarthritic chondrocytes were incubated with Co (1.02-16.33 ppm) and Cr (0.42-6.66 ppm) ions at different concentrations. As metal ion levels in the joint after UKA have not been reported, CoCr ions concentrations tested were set according to the findings in MoM bearings.…”

Section: Discussionmentioning

confidence: 99%

Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective Cobalt and chromium (CoCr) ions from metal implants are released into the joint due to biotribocorrosion, inducing apoptosis and altering gene expression in various cell types. Here, we asked whether CoCr ions concentration-dependently changed viability, transcriptional activity, and inflammatory response in human articular chondrocytes. Design Human articular chondrocytes were exposed to Co (1.02-16.33 ppm) and Cr (0.42-6.66 ppm) ions and cell viability and early/late apoptosis (annexin V and 7-AAD) were assessed in 2-dimensional cell cultures using the XTT assay and flow cytometry, respectively. Changes in chondrocyte morphology were assessed using transmitted light microscopy. The effects of CoCr ions on transcriptional activity of chondrocytes were evaluated by quantitative polymerase chain reaction (qPCR). The inflammatory responses were determined by measuring the levels of released pro-inflammatory cytokines (interleukin-1β [IL-1β], IL-6, IL-8, and tumor necrosis factor–α [TNF-α]). Results CoCr ions concentration-dependently reduced metabolic activity and induced early and late apoptosis after 24 hours in culture. After 72 hours, the majority of chondrocytes (>90%) were apoptotic at the highest concentrations of CoCr ions (16.33/6/66 ppm). SOX9 expression was concentration-dependently enhanced, whereas expression of COL2A1 linearly decreased after 24 hours. IL-8 release was enhanced proportionally to CoCr ions levels, whereas IL-1β, IL-6, and TNF-α levels were not affected by the treatments. Conclusions CoCr ions showed concentration- and time-dependent effects on articular chondrocytes. Fractions of apoptotic articular chondrocytes were proportional to CoCr ion concentrations. In addition, metabolic activity and expression of chondrocyte-specific genes were decreased by CoCr ions. Furthermore, exposure to CoCr ions caused a release of pro-inflammatory cytokines.

show abstract

“…Murine chondrocytes, bovine chondrocytes and cartilage explants were associated with reduced inflammatory IL-1β signalling chondrocytes after cyclic mechanical loading [58]. Osteochondral cylinders isolated from bovine stifle joints showed upregulated COL2A1 and ACAN gene expression and increased metabolic activity after high load [59].…”

Section: Common Risk Factors For Oa and Cvdmentioning

confidence: 97%

Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

Vaiciuleviciute

Bironaitė

Uzielienè

et al. 2021

Cells

View full text Add to dashboard Cite

Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, β-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols.

show abstract

Effects of Loading Conditions on Articular Cartilage in a Metal‐on‐Cartilage Pairing

Cited by 14 publications

References 46 publications

Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulation

Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulation

Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes

Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

Contact Info

Product

Resources

About