Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study

Effect of platelet-rich plasma on the rate of orthodontic tooth movement:

“…[28][29][30] In the last month of the study period, results showed a nonsignificant difference in the rate of canine retraction between the two sides. The rate of canine retraction on the control side was slightly more than that reported by Aboul-Ela et al 12 and less than that reported by Hayashi et al 31 On the other hand, Gülec et al 10 reported that PRP induced acceleration of orthodontic tooth movement by 1.4 to 1.7 times. Similarly, Rashid et al 5 reported a higher value of acceleration (PRP:control rate ¼ 2.13:1) compared with the present study.…”

“…20 Textor and Tablin 21 showed that calcium chloride activation might be the most inexpensive and effective method, although it might need 20 minutes for activation of PRP. 20 The injection technique in five different areas around the retracted canine followed the same protocol reported by Rashid et al 5 This may be compared with the findings of Gülec et al, 10 who injected the PRP only at the buccal vestibular mucosa adjacent to the mesial root of the first molar. Intraligamentary injection at the distobuccal and distopalatal surfaces of the canine root was advocated in this study based on the work by Von Böhl et al, 22,23 who reported that, as a consequence of local stress and shear concentrations, most hyalinized areas were not found in the area of the central plane but rather lingually and buccally from it.…”

“…24 Conversely, previous studies evaluating the effects of local pharmacologic agent injection to accelerate tooth movement reported only one or two submucosal or gingival injection sites. 4,10,[25][26][27] Injections were delivered every 3 weeks and repeated until the sixth week following the protocol reported by Rashid et al 5 Although the study continued for 4 months, injections were not continued through the whole duration of the study in order to determine whether PRP injections were enough in the initial phases of tooth movement only, as compared with corticotomy 12 or low-level laser therapy applications. 3 The results of the current study showed a faster rate of canine retraction on the intervention side in the first month by 15% and in the second month by 5%.…”

“…9 The relationship between PRP and orthodontic tooth movement has drawn some attention lately. In two recently published animal studies, Rashid et al 5 and Gülec et al 10 evaluated the effects of PRP on tooth movement. Both studies showed a positive correlation between local injection of PRP and acceleration of orthodontic tooth movement.…”

Effects of Leukocyte-Platelet-Rich Plasma on the Alveolar Bone Changes During Orthodontic Tooth Movement in Rabbits: A Micro-CT Study

“…This finding agreed with a previous study that reported decreased alveolar bone density that began on day 3 and was more significant on day 7 in PRP injected rats. 13 Meanwhile, the results in the control group demonstrated that the reduction of alveolar bone density remained steady from day 3 to 7 and then dropped considerably after the first week. In accordance with the phases of orthodontic tooth movement, the initial phase is a rapid tooth movement that occurs in a few days after force application.…”