Effects of long-term consumption of energy drinks on the body and brain weights of adult Wistar rats

Adjene, Josiah Obaghwarhievwo; Emojevwe, Victor; Idiapho, David Eseoghene

doi:10.4103/1596-2393.142925

Cited by 11 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with previous studies. [11][12][13] Eluwa et al 13 conducted study on the histology of cerebellum after intake of soda carbonated soft drinks to female albino rats and found deleterious effects similar to the present study. Ferraro et al 9 concluded that the sugar containing soft drinks are associated with renal injury with predisposition of renal stone formation.…”

Section: Discussionsupporting

confidence: 84%

“…As the albuminuria is a surrogate marker of glomerular injury, this needs action against the use of soft cola drink. 6,7 The fructose containing carbonated soft drinks is a risk factor for the systemic hypertension, diabetes mellitus, kidney stone and chronic kidney disease (CKD). As the use of soft cola drinks is prevalent not only in large cities but also in villages where non-branded low cost drinks are available, but its adverse health issues are never reported.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adverse Effects of Non-Branded Soft Drink

Almani

Memon

Shaikh

2018

TPMJ

View full text Add to dashboard Cite

Objectives: Investigating the Adverse effects of non-branded soft drink on therenal histology in an albino rat model. Study Design: Experimental study. Place and Duration:Department of Anatomy, Isra University, in collaboration with Animal House, Department ofAnimal Husbandry and Veterinary Sciences, Sindh Agriculture University Tando Jam over sixmonths duration 2014. Methodology: A sample of 30 adult Wistar albino rats of was selectedaccording to criteria. Animals were randomly divided into 3 groups. Group A (n=10) controlrats, Group B (n=10) control rats given normal diet (12 hours fasting) and Group C (n=10)experimental rats. 3- 5 μ thick renal tissue sections were prepared, stained with H & E andexamined by light microscopy. Data was analyzed on statistical software SPSS 21.0 ver(IBM, incorporation, USA) at 95% (α)-level significance was taken at P-value ≤ 0.05. Results:Experimental group C showed an increase in kidney size and weight observed even after 12hours of fasting (P=0.0001). Histological examination of experimental kidneys show gapingBowman`s capsules, interstitial edema, glomerular distortion, calcifications, acidophilichyalinization of renal tubules, vacuolization of epithelial cell, pyknotic nuclei and necrosis.Epithelial cells revealed fragmentation and sloughing in experimental rat kidney. Conclusion:The present study reports deleterious adverse effects of non-branded soft drink on the renalhistology in an experimental albino rat model.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Adverse Effects of Non-Branded Soft Drink

Almani

Memon

Shaikh

2018

TPMJ

View full text Add to dashboard Cite

show abstract

“…However, there was no significant difference in the effects of the long term consumption of instant noodles on the liver weight of the rats (p < 0.05). This is in line with study conducted by Adjene, et al 2017 on the effects of long-term consumption of instant noodles on the body and brain weights of adult Wistar rats [27].…”

Section: Fig 1 Comparison Of Histological Changes Between Control Asupporting

confidence: 92%

Morpho-functional Changes in Liver due to Long Term Consumption of Instant Noodles in Adult Wistar Rats

Saleh

Obaghwarhievwo

Obiajulu

et al. 2019

AJRB

View full text Add to dashboard Cite

Introduction: Food is a basic requirement for the survival of living organisms, and is also necessary for growth, development, replacement and repairs of worn-out tissues, as well as energy production for various body functions, among others. Aim: Current study investigated the histo-architectural and biochemical changes in the liver due to prolonged consumption of instant noodles by Wistar rats. Methods: Fifty (50) adult Wistar rats of an average weight of 200 g were procured for the study. Following two weeks of acclimatization, the animals were randomly assigned into five (5) groups (A, B, C, D and E) of ten (10) rats each. Group A received cooked instant noodle (Type A) only; whereas, group B rats were fed with cooked instant noodles with its spice. Group C received cooked instant noodles (type B) only. Group D received cooked instant noodles type B with its spice while group E were fed with grower marsh (control). After thirty (30) days of administration of test substances, rats were sacrifice by cervical dislocation and liver tissue obtained for histological technique and bioassay of selected antioxidant enzyme levels [Catalase, Malonyldialdehyde (MDA), Glutathione Peroxidase (GPx) and superoxide Dismutase (SOD)]. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS version 21) to evaluate the result obtained. Histological section of liver of the treated animals showed cellular degenerative changes, hypertrophy, hepatic steatosis and mild fibrosis which were sparsely distributed as compared to the control group. Results: Biochemical assay of oxidative stress markers revealed that MDA levels were significantly (p < 0.05) increased in all treated liver groups as compared with the parallel control animals. Concomitantly, the levels of SOD levels were found to be significantly (p < 0.05) decreased in the treated liver groups as compared with the control. Conclusion: Thus, long consumption of instant noodles exert toxic effects by promoting oxidative stress in the liver tissue of adult Wistar rats. Recommendation: Further study aimed at corroborating these findings should be carried out.

show abstract

“…So energy drinks behave as a toxin to parenchymal cells and could affect cellular integrity resulting in disturbed membrane permeability with subsequent changes in homeostasis of cell volume. This occurs as a result of increased rate of catabolism due to high insulin availability caused by sweetening gradients present in energy drinks [43,44] .…”

Section: Discussionmentioning

confidence: 99%

Effect of a caffeinated energy drink and its withdrawal on the submandibular salivary gland of adult male albino rats: A histological and immunohistochemical study

Kassab

Tawfik

2018

Egyptian Journal of Histology

View full text Add to dashboard Cite

Introduction: Energy drinks provide the consumer witha combination of stimulants and energy boosters that increases the physical endurance, concentration, muscular performance and mood. Despite their benefits, many health hazards occur that may be attributed to its caffeine content. Aim: To study the effect of a caffeinated energy drink on the histological structure of submandibular salivary gland of albino rats and evaluation of the effect of its withdrawal. Materials and Methods: Thirty adult male albino rats were divided into 3 equal groups: control group, group II (received the energy drink in a dose 3.75 ml/Kg daily orally for 8 weeks), group III (received the energy drink in a dose 3.75 ml/Kg daily orally for 8 weeks, and left for another 8 weeks without treatment). The submandibular salivary gland specimens were taken and prepared for light and electron microscopic study and immunohistochemical staining for myoepithelial cells using anti α-SMA antibody. Results: Specimens from group II showed disturbance of the normal structure of the submandibular salivary glands. The lining epithelium of the acini and ducts showed cytoplasmic vacuoles with compressed or pyknotic nuclei. Disturbance of the basal striation of the cells lining striated ducts. There was deposition of abundant collagen fibers between the lobules and around the acini and ducts. A statistically highly significant increase in α-SMA immunoreaction was noticed around the acini, intercalated, striated and granular ducts. Ultrastructurally, fusion of the secretory granules, swollen mitochondria, dilatation and fragmentation of rough endoplasmic reticulum of the acinar cells were observed. Amelioration of the previous histological changes was detected in group III after withdrawal of the caffeinated energy drink. Conclusion: The caffeinated energy drink induced structural changes in the submandibular salivary gland of Albino rats which were partially ameliorated by its withdrawal. So, excessive intake of the caffeinated energy drinks should be considered as health hazard for human.

show abstract

Effects of long-term consumption of energy drinks on the body and brain weights of adult Wistar rats

Cited by 11 publications

References 0 publications

Adverse Effects of Non-Branded Soft Drink

Adverse Effects of Non-Branded Soft Drink

Morpho-functional Changes in Liver due to Long Term Consumption of Instant Noodles in Adult Wistar Rats

Effect of a caffeinated energy drink and its withdrawal on the submandibular salivary gland of adult male albino rats: A histological and immunohistochemical study

Contact Info

Product

Resources

About