Effects of long-term feeding of α-glucosylhesperidin on the mechanical properties of rabbit femoral arteries

Abstract

Many people are sensitive to cold, resulting in poor blood circulation. There is evidence that hesperidin results in increased peripheral circulation and skin temperature. A transglycosylated hesperidin, α-glucosylhesperidin, is more bioabsorbable than hesperidin. In the present study, biomechanical studies were performed on the effects of long-term feeding of α-glucosylhesperidin on the contractile response (diameter response) and stiffness of femoral arteries excised from rabbits. Animals in the normal (non-treated), low, and high groups were fed 0, 150 and 4500 mg/day, respectively, of α-glucosylhesperidin for about 24 weeks. The feeding of α-glucosylhesperidin did not change arterial stiffness nor mean blood flow rate in the femoral artery; however, it increased mean aortic blood pressure and decreased arterial diameter at 100 mmHg in the high group. The diameter responses developed by 10−5 M of norepinephrine were significantly lower in the high and low groups than in non-treated group. This result indicates that, due to the long-term feeding of α-glucosylhesperidin, arterial contraction induced by the neurotransmitter of sympathetic nerves decreases. It was estimated that blood flow in such muscular arteries as the femoral artery is maintained at normal by α-glucosylhesperidin even under the conditions of autonomic imbalance and cold intolerance.

Effects of lycium and lycium-composed formula on the peripheral coldness induced by local cooling in mice

“…5), and lycium or LLA led to the faster recovery of the skin surface temperature, thus it is expected to protect the body from heat loss. Hesperidin composed in lycium fruits and LLA, which can increase peripheral circulation and skin temperature under coldness [24,25], thus supports the present study. Furthermore, the polysaccharides of lycium fruits shown antihypertensive effect by a significant decrease in the concentration of phenylephrine in isolated aortic rings [22], and improved the thoracic aorta vasoreactivity in rats under exhaustive exercise [27].…”

“…Furthermore, it has been reported that polysaccharides the increase of blood pressure in hypertension rats, and the arterial compliance by up-regulation of the eNOS expression and improvement of the endothelium the rat aorta ring [22,23]. In addition, hesperidin, a flavonoid composed in lycium fruits [9], resulted in increased peripheral circulation and skin temperature under cold intolerance and rat models [24,25]. On the other hand,…”