Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats

Nozawa, Takashi; Igawa, Akihiko; Fujii, Naohiko; Kato, Bunichi; Yoshida, Naohiro; Asanoi, Hidetsugu; Inoue, Hiroshi

doi:10.1007/s380-002-8317-8

Cited by 86 publications

(64 citation statements)

References 37 publications

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“…Recently, the therapeutic value of renal denervation in heart failure was evaluated in a similar experimental model of coronary ligation-induced myocardial infarction in rats. 45 This study, in which renal denervation was performed before onset of myocardial infarction, demonstrated reduced ventricular filling pressure and improved ventricular function compared with nondenervated controls. As in hypertension, deliberate renal denervation has been exploited to gain physiological insights into pathological conditions.…”

Section: Postmyocardial Infarction and Congestive Heart Failurementioning

confidence: 70%

Renal Denervation as a Therapeutic Approach for Hypertension

et al. 2009

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Section: Postmyocardial Infarction and Congestive Heart Failurementioning

confidence: 70%

Renal Denervation as a Therapeutic Approach for Hypertension

et al. 2009

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“…156,157 Davies et al 158 have recently reported the results of a pilot study of 7 patients with chronic systolic HF, who underwent bilateral renal denervation and were followed up for 6 months. The study found no procedural or postprocedural complications.…”

Section: Use Of Devices To Modulate Autonomic Nervous System In Hfmentioning

confidence: 99%

The Autonomic Nervous System and Heart Failure

Florea

Cohn

2014

Circulation Research

453

366

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Abstract:The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities that result in neurohormonal activation and autonomic imbalance with increase in sympathetic activity and withdrawal of vagal activity. Alterations in receptor activation from this autonomic imbalance may have profound effects on cardiac function and structure. Inhibition of the sympathetic drive to the heart through β-receptor blockade has become a standard component of therapy for HF with a dilated left ventricle because of its effectiveness in inhibiting the ventricular structural remodeling process and in prolonging life. Several devices for selective modulation of sympathetic and vagal activity have recently been developed in an attempt to alter the natural history of HF. The optimal counteraction of the excessive sympathetic activity is still unclear. A profound decrease in adrenergic support with excessive blockade of the sympathetic nervous system may result in adverse outcomes in clinical HF. In this review, we analyze the data supporting a contributory role of the autonomic functional alterations on the course of HF, the techniques used to assess autonomic nervous system activity, the evidence for clinical effectiveness of pharmacological and device interventions, and the potential future role of autonomic nervous system modifiers in the management of this syndrome. (Circ Res. 2014;114:1815-1826.) Key Words: autonomic nervous system ■ heart failure ■ norepinephrine ■ receptors, adrenergicThe Autonomic Nervous System and Heart Failure Viorel G. Florea, Jay N. Cohn This Review is in a thematic series on The Autonomic Nervous System and the Cardiovascular System, which includes the following articles: Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias [Circ Res. 2014;114:1004-1021 The Autonomic Nervous System and Hypertension [Circ Res. 2014;114:1804-1814 The Autonomic Nervous System and Heart Failure Renal Denervation for the Treatment of Cardiovascular High Risk-Hypertension or Beyond? Original received February 10, 2014; revision received April 29, 2014; accepted April 29, 2014. In March 2014, the average time from submission to first decision for all original research papers submitted to Circulation Research was 12.63 days.From the Minneapolis VA Health Care System, Section of Cardiology (V.G.F.) and Rasmussen Center for Cardiovascular Disease Prevention, Department of Medicine (J.N.C.), University of Minnesota Medical School.Correspondence to Jay N. endocardium. Parasympathetic effects are carried by the right and left vagus nerves, originating in the medulla. The vagus nerve further divides into the superior and inferior cardiac nerves, finally merging with the postganglionic sympathetic neurons to form a plexus of nerves at the base of the heart, known as the cardiac plexus. 1The 2 mediators of the SNS, norepinephrine and epinephrine, derive from 2 major sources in the body: the sympathetic nerve endings, which release norepinephrine directly into the synaptic cleft, and the adren...

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“…The reduction in sympathetic activity with renal sympathetic denervation might be expected to have similar benefits. Not surprisingly, decreased left ventricular filling pressures and improved left ventricular systolic function has been demonstrated following renal denervation in rats (47). Future studies will provide a better understanding of renal sympathetic denervation and the subsequent changes in heart failure pathophysiology.…”

Section: Future Directionsmentioning

confidence: 88%

Renal denervation

Drexel¹,

Bertog²,

Vaškelytė³

et al. 2014

Anadolu Kardiyol Derg

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Severe hypertension, resistant to conventional antihypertensive medications, is associated with major adverse cardiovascular and cerebrovascular events and renal insufficiency. Renal sympathetic nerve over-activity frequently accompanies essential hypertension. Catheter-based renal sympathetic denervation leads to a reduction in renal and overall sympathetic nerve activity and improvement in blood pressure in the setting of severe resistant hypertension. In the following, we review the role of the renal sympathetic nervous system in blood pressure control and recent clinical experience with renal denervation. Furthermore, potential beneficial effects on diabetes control, obstructive sleep apnea, atrial and ventricular arrhythmias are discussed. (Anadolu Kardiyol Derg 2014; 14: 186-91)

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Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats

Cited by 86 publications

References 37 publications

Renal Denervation as a Therapeutic Approach for Hypertension

Renal Denervation as a Therapeutic Approach for Hypertension

The Autonomic Nervous System and Heart Failure

Renal denervation

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