Effects of long-term voluntary exercise on learning and memory processes: dependency of the task and level of exercise

García-Capdevila, Sílvia; Portell-Cortès, Isabel; Torras-Garcia, Meritxell; Coll-Andreu, Margalida; David, Cristhian

doi:10.1016/j.bbr.2009.03.020

Cited by 61 publications

(41 citation statements)

References 84 publications

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“…Although some evidences have indicated the significant promotion of cognitive performance, learning and memory by physical activities (Ang and Gomez-Pinilla, 2007;Cotman and Berchtold, 2002;García-Capdevila et al, 2009;Leasure and Jones, 2008;Lin et al, 2012;Saadati et al, 2010;Van Praag et al, 1999) other studies, in agreement with our findings, have revealed lack of improvement (Titterness et al, 2011;Zagaar et al, 2012a,b). This controversy OVX (ovariectomized) (B) female rats.…”

Section: Discussionsupporting

confidence: 93%

Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats

Saadati

Sheibani

Esmaeili‐Mahani

et al. 2014

Brain Research Bulletin

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Section: Discussionsupporting

confidence: 93%

Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats

Saadati

Sheibani

Esmaeili‐Mahani

et al. 2014

Brain Research Bulletin

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“…The lack of behavioural and cognitive effects of intermittent wheel running in our study raises the question of whether there are optimal levels of exercise for behavioural changes to occur. Indeed, a study in rats found that behavioural effects of exercise were dependent on the task and exercise level with low intensity runners showing improved object recognition memory and high intensity runners being impaired, however, increased anxiogenic-like reactions were observed regardless of the exercise level [38]. In contrast, our correlation data would suggest that the mice keener on running are better at spatial discrimination and are less curious whilst also being more emotional.…”

Section: Intermittent Voluntary Wheel Running Does Not Alter Behavioucontrasting

confidence: 50%

“…In contrast, our correlation data would suggest that the mice keener on running are better at spatial discrimination and are less curious whilst also being more emotional. The source of this discrepancy could be the specie or related to exercise levels as we applied an intermittent exercise regimen while the study reported provided unlimited access to wheel running [38]. The timing of exercise can also be a significant factor.…”

Section: Intermittent Voluntary Wheel Running Does Not Alter Behavioumentioning

confidence: 99%

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

Ebada

Kendall

Pardon

2016

Behavioural Brain Research

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Number of tables: 1Number of words in the abstract: 248Number of words in the manuscript (including tables and figure legends): 6,639Number of words in the introduction: 1,290Number of words in the discussion: 1,243 ABSTRACT Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivation on subsequent behaviour, we used a pharmacological approach targeting some reward mechanisms. The stress hormone corticosterone has rewarding effects mediated by activation of low affinity glucocorticoid receptors (GR). To investigate whether corticosterone synthesis motivates exercise via activation of GRs and subsequently, impacts on behaviour, we treated C57BL/6J mice acutely with the inhibitor of corticosterone synthesis metyrapone (35 mg/kg) or repeatedly with the GR antagonist mifepristone (30 mg/kg) prior to 1-hour running wheel sessions. To investigate whether reducing motivation to exercise impacts on behaviour, we antagonised running-induced dopamine D2/D3 receptors activation with sulpiride (25 or 50 mg/kg) and assessed locomotor, anxiety-related and memory performance after 20 running sessions over 4 weeks. We found that corticosterone synthesis contributes to running levels, but the maintenance of running behaviour was not mediated by activation of GRs. Intermittent exercise was not associated with changes in behavioural or cognitive performance. The persistent reduction in exercise levels triggered by sulpiride also had limited impact on behavioural performance, although the level of performance for some behaviours was related to the level of exercise. Altogether, these findings indicate that corticosterone and dopamine D2/D3 receptor activation contribute to the motivation for wheel running, but suggest that motivation for exercise is not a sufficient factor to alter behaviour in healthy mice.

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“…Exercise can improve object recognition memory (Griffin et al, 2009;Hopkins, Bucci, 2010), but also impair it (Drumond et al, 2012;Mello et al, 2008), depending on the duration and type of activity, and on the integrity of the perirhinal cortex and hippocampus (García-Capdevila et al, 2009). Our results demonstrated that both exercise groups had stronger preference for the novel object, indicating that treadmill running, at moderate intensity, is able to enhance the performance in a nonspatial memory task in control and diabetic rats.…”

Section: Discussionmentioning

confidence: 50%

Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats

Senna¹,

Xavier²,

Bagatini³

et al. 2015

Brain Research

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Effects of long-term voluntary exercise on learning and memory processes: dependency of the task and level of exercise

Cited by 61 publications

References 84 publications

Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats

Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats

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