Effects of losartan and l-serine in a mouse liver fibrosis model

Yun, Hyun Ho; Park, Sunyoung; Chung, Myung-Jin; Son, Jun‐Hyeok; Park, Jaemin; Jung, Seung-Jun; Yim, Jae-Hyuk; Kang, Kyung-Ku; Byeon, Seongrim; Baek, Su-Min; Lee, Seoung-Woo; Lee, A-Rang; Kim, Tae‐Hwan; Park, Jin‐Kyu; Jeong, Kyu‐Shik

doi:10.1016/j.lfs.2021.119578

“…67,68 Primary hyperoxalurias (PHs) is a disorder of liver glyoxylate metabolism with abnormal endogenous oxalate production. 69 In this study, disturbances in lactic acid and ethanedioic acid demonstrated that liver damage may be related to energy metabolism.…”

Section: Discussionmentioning

confidence: 60%

Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS

Liu

¹

,

Tian

²

,

Wang

³

et al. 2023

RSC Adv.

1

0

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“…The liver fibrosis model was constructed by carbon tetrachloride (CCl 4 )-induction in C57BL/6 J mice [38] (Figure 6). Fibrosis formed after four weeks of low-dose CCl 4 (20 % v/v) induction and promoted after eight weeks, then aggravated with high-dose CCl 4 (33 % v/v) induction for another four weeks.…”

Section: Monitoring Gsh Levels In Liver Fibrosismentioning

confidence: 99%

A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione

Li

¹

,

Wang

²

,

Wang

³

et al. 2023

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Quantifying glutathione (GSH) in cells and organisms is of great significance for understanding the mechanism of oxidative stress in various physiological and pathological processes. However, the quantification by fluorescence bioimaging in living tissues has much stricter requirements than the "Petri dish"-cultured cells in flat plates. Based on the evaluation of the electronic structure and steric hindrance-tuned reactivity of phospha-substituted rhodamine with GSH, a reversible Förster resonance energy transfer (FRET) probe ZpSiP with a distinct performance (K d = 4.9 mM, t 1/2 = 0.57 s, k = 81 M À 1 s À 1 ) is developed for real time quantifying GSH in living cells. Furthermore, the near-infrared (NIR) probe succeeded in sensitively tracking the dynamics of GSH in the real organisms bearing tumors, chronic renal failure, and liver fibrosis for unveiling the related pathological processes. We believe that the advance in chemistry with quantitative analysis methods will initiate more promising progress and broad applications.

show abstract

A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione

Li

¹

,

Wang

²

,

Wang

³

et al. 2023

View full text Add to dashboard Cite

Quantifying glutathione (GSH) in cells and organisms is of great significance for understanding the mechanism of oxidative stress in various physiological and pathological processes. However, the quantification by fluorescence bioimaging in living tissues has much stricter requirements than the "Petri dish"-cultured cells in flat plates. Based on the evaluation of the electronic structure and steric hindrance-tuned reactivity of phospha-substituted rhodamine with GSH, a reversible Förster resonance energy transfer (FRET) probe ZpSiP with a distinct performance (K d = 4.9 mM, t 1/2 = 0.57 s, k = 81 M À 1 s À 1 ) is developed for real time quantifying GSH in living cells. Furthermore, the near-infrared (NIR) probe succeeded in sensitively tracking the dynamics of GSH in the real organisms bearing tumors, chronic renal failure, and liver fibrosis for unveiling the related pathological processes. We believe that the advance in chemistry with quantitative analysis methods will initiate more promising progress and broad applications.

show abstract

Effects of losartan and l-serine in a mouse liver fibrosis model

Cited by 9 publications

References 30 publications

Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS

Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS

A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione

A Substituted‐Rhodamine‐Based Reversible Fluorescent Probe for In Vivo Quantification of Glutathione

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