Effects of Lovastatin(Mevacor®) on Lowering Plasma Lipids in Patients with Hyperlipidemia

Lee, Hyang Joo; Min, Chul Hong; Choi, Kang Sik; Ryu, Wang Seong; Ryoo, Un Ho

doi:10.4070/kcj.1991.21.4.781

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Pharmacological Therapy For Dyslipidemia1

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Cited by 4 publications

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“…Multiple studies on Koreans have reported the effects of each type of statin on lipid indices and some studies have shown that the same dose of statin leads to a greater reduction of LDL-C among Koreans than among foreigners (Figs. 9 and 10) [92-113].…”

Section: Pharmacological Therapy For Dyslipidemiamentioning

confidence: 99%

2018 Guidelines for the management of dyslipidemia

Rhee

Kim

et al. 2019

Korean J Intern Med

163

128

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Section: Pharmacological Therapy For Dyslipidemiamentioning

confidence: 99%

2018 Guidelines for the management of dyslipidemia

Rhee

Kim

et al. 2019

Korean J Intern Med

163

128

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Statin intolerance: an updated, narrative review mainly focusing on muscle adverse effects

Liu

et al. 2020

Expert Opinion on Drug Metabolism & Toxicology

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Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

Kwon

Kim

Hyun

et al. 2014

J Lipid Atheroscler

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Objective: The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients. Methods: A total of 909 consecutive patients were enrolled prospectively according to the criteria of National Cholesterol Education Program guidelines. Lipid profiles were obtained before and 2 months after statin therapy. Results: Atorvastatin 10 mg (n=260), lovastatin 20 mg (n=145), pitavastatin 2 mg (n=80), pravastatin 20 mg (n=28), rosuvastatin 5 mg (n=145), and simvastatin 20 mg (n=208) reduced low density lipoprotein (LDL) cholesterol by -41.8±11.0%, -33.8±12.8%, -39.3±10.8%, -31.5±8.9%, -48.8±12.3%, and -42.8±13.5%, respectively. LDL cholesterol less than 130 mg/dL was achieved in 90.3%, 76.9%, 88.5%, 85.2%, 97.2%, and 94.2%, respectively. The reduction of LDL cholesterol by 30% or more was obtained in 84.4%, 60.7%, 81.6%, 63.0%, 93.0%, and 83.5%, respectively. LDL cholesterol less than 70 mg/dL or the reduction by 50% or more was observed in a small portion of patients and was variable according to the different types of statins. Conclusion: A low dose statin was enough to manage dyslipidemia in most Korean patients with low to moderate risks and was even effective in a subpopulation of high risk patients.

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Effects of Lovastatin(Mevacor®) on Lowering Plasma Lipids in Patients with Hyperlipidemia

Cited by 4 publications

References 0 publications

2018 Guidelines for the management of dyslipidemia

2018 Guidelines for the management of dyslipidemia

Statin intolerance: an updated, narrative review mainly focusing on muscle adverse effects

Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

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