Effects of low concentrations copper on antioxidant responses, DNA damage and genotoxicity in thick shell mussel Mytilus coruscus

Xu, Kang; Tang, Zurong; Liu, Shuobo; Liao, Zhi; Hu, Xia; Liu, Lianwei; Wang, Zhongming; Qi, Pengzhi

doi:10.1016/j.fsi.2018.08.016

Cited by 39 publications

(11 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whilst copper exposure often leads to increased lipid peroxidation (e.g. Brown et al, 2004;Maria and Bebianno, 2011) and changes in activity of the anti-oxidant enzyme SOD (Xu et al, 2018), here we found no significant changes in lipid peroxidation or SOD activity in A. virens in response to copper under ambient seawater pH/pCO2 conditions. This again is in contrast to the responses previously reported for the mussel Mytilus edulis and the sea urchin Paracentrotus lividus (Lewis et al, 2016), further supporting the idea that this A. virens is relatively robust to copper contamination.…”

Section: Discussioncontrasting

confidence: 77%

Ocean acidification buffers the physiological responses of the king ragworm Alitta virens to the common pollutant copper

2019

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 77%

Ocean acidification buffers the physiological responses of the king ragworm Alitta virens to the common pollutant copper

2019

View full text Add to dashboard Cite

show abstract

“…Excess in • OH increases the production of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). In particular, several studies have reported an increase in SOD activities after exposure to mussels at low but environmentally relevant copper concentrations (Bigot, Minguez, Giambérini, & Rodius, ; Wu et al, ; Xu et al, ). For these reasons, copper is the most toxic metal after mercury and silver to a wide spectrum of marine life.…”

Section: Introductionmentioning

confidence: 99%

Molecular effects of copper on the reproductive system of mytilus galloprovincialis

Lettieri

Mollo

Ambrosino

et al. 2019

Molecular Reproduction Devel

View full text Add to dashboard Cite

This study aims to assess the effects induced by 24 hr exposure to a subtoxic copper concentration on the reproductive system (gonads, spermatozoa, and protamine-like[PL] proteins) of Mytilus galloprovincialis. Inductively coupled plasma-mass spectrometry indicated accumulation of this metal in gonads, spermatozoa, and PL proteins of exposed mussels. Further, real-time polymerase chain reaction analyses showed altered expression levels of mt10 and PL proteins genes in spermatozoa and gonads, respectively, of exposed mussels. Protamine-like proteins, which represent the main basic component of sperm chromatin of this organism, showed a higher DNA binding affinity and a different DNA binding mode in exposed mussels. Moreover, an increased amount of NaCl was required for the release from sperm nuclei of PL-III, the main PL protein component. Finally, PL proteins extracted from exposed mussels promoted DNA oxidative damage in the presence of H 2 O 2. These results demonstrate that the tolerable copper amount could also affect the properties of PL proteins and determine the negative effects on the reproductive system of this organism. These analyses could be useful to develop quick and efficient chromatin-based genotoxicity tests for pollution biomonitoring programs.

show abstract

“…Exposure to Cu may trigger upregulation of metallothioneins 34 , cytochrome P450, heat shock proteins, ferritin, glutathione peroxidase (GPx) and glutathione S-transferase (GST). These play a role in xenobiotic metabolism, detoxification, antioxidant defense or stress response of marine copepods, such as T. japonicus 35,36 and other marine species, such as Mytilus coruscus 37 .…”

Section: Discussionmentioning

confidence: 99%

Development of metal adaptation in a tropical marine zooplankton

Dinh

Pham

et al. 2020

Sci Rep

View full text Add to dashboard Cite

tropical marine ecosystems are highly vulnerable to pollution and climate change. it is relatively unknown how tropical species may develop an increased tolerance to these stressors and the cost of adaptations. We addressed these issues by exposing a keystone tropical marine copepod, Pseudodiaptomus annandalei, to copper (Cu) for 7 generations (F1-F7) during three treatments: control, Cu and pCu (the recovery treatment). In F7, we tested the "contaminant-induced climate change sensitivity" hypothesis (TICS) by exposing copepods to Cu and extreme temperature. We tracked fitness and productivity of all generations. In F1, Cu did not affect survival and grazing but decreased nauplii production. In F2-F4, male survival, grazing, and nauplii production were lower in Cu, but recovered in pCu, indicating transgenerational plasticity. Strikingly, in F5-F6 nauplii production of Cu-exposed females increased, and did not recover in pCu. The earlier result suggests an increased Cu tolerance while the latter result revealed its cost. In F7, extreme temperature resulted in more pronounced reductions in grazing, and nauplii production of Cu or pCu than in control, supporting TICS. The results suggest that widespread pollution in tropical regions may result in high vulnerability of species in these regions to climate change.

show abstract

Effects of low concentrations copper on antioxidant responses, DNA damage and genotoxicity in thick shell mussel Mytilus coruscus

Cited by 39 publications

References 56 publications

Ocean acidification buffers the physiological responses of the king ragworm Alitta virens to the common pollutant copper

Ocean acidification buffers the physiological responses of the king ragworm Alitta virens to the common pollutant copper

Molecular effects of copper on the reproductive system of mytilus galloprovincialis

Development of metal adaptation in a tropical marine zooplankton

Contact Info

Product

Resources

About