Effects of low concentrations of synthetic antioxidant phenosan potassium salt on the thermoinduced structural transitions in the protein component of plasma membranes

Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H2O2-Induced Cytotoxicity in Tumour Cells

“…The S- and Se-containing analogues of phenosanacid can exceed phenosan in the antioxidant activity owing to the presence of S and Segroups, as demonstrated successfully for phenolic compounds containing sulphide groups [ 42 ]. To create a water-soluble antioxidant, a phenosanacid potassium salt was synthesized (potassium phenosan), which, just as phenosanacid, is a promising pharmacologically active substance for use in biology and medicinal chemistry [ 43 , 44 ]. In this regard, the reaction of hydrophobic acids with KHCO 3 synthesises the corresponding hydrophilic salts: Se- and S-containing analogues of potassium phenosan [ 35 ].…”

Disperse Systems Based on a Dodecyl Derivative of p-Sulfonatocalix[6]arene: Self-Organization and Physicochemical Properties in a Wide Range of Concentrations and Temperatures

“…For example, the study of dilute solutions of potassium phenozane antioxidant (PP) by the DSC method showed that the PP solutions used in the range of formation of domains and nanoassociates [2,3] change the thermostability of the protein fraction of plasma membranes in the opposite direction -in the domain formation range, it increases, and in the nanoassociation formation region it is reduced. [27] Both domains and nanoassociates, starting at t>55 °C, are destroyed, the maximum deviations from additivity are observed in both cases in the 50-60 °C interval. Therefore, the peak on the …”