Effects of low‐dose cimetidine on nocturnal acid secretion in healthy subjects

Acton, G; Broom, Colin; Wareham, Kathryn; Laroche, J.; Burnham, Daniel B.; Friedman, Constance L.

doi:10.1111/j.1365-2036.1991.tb00006.x

Cited by 2 publications

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Low dose famotidine and cimetidine in single postprandial doses: a placebo controlled comparative study of overnight pH.

Reilly

Mann²,

Panos³

et al. 1995

Gut

View full text Add to dashboard Cite

To investigate the relative abilities of low doses of famotidine and cimetidine to raise intragastric pH after a single postprandial evening dose, 16 healthy volunteers were recruited to a four period crossover trial of famotidine 10 mg, cimetidine 100 mg and 200 mg compared with placebo. Intragastric pH was monitored between 1800 and 0730 with a nasogastric pH electrode. Median gastric pH rose from 1.35 (interquartile range 1-1-1-65) with placebo to 1 95 (1.6-5.35, p0.2) after cimetidine 100 mg. Intragastric pH was above 3 for 34% (p<0.005) of the time after dosing with famotidine, compared with 13.6% (p>0.2) after cimetidine 200 mg, 9.5% (p>02) after cimetidine 100 mg, and 4.7% after placebo. The rise of intragastric pH after famotidine 10 mg is significantly greater than that after either 200 mg or 100 mg cimetidine when the drugs are used postprandially. (Gut 1995; 37: 325-328) Keywords: H2 receptor antagonist, intragastric pH, famotidine, cimetidine. Study designThe investigation was designed as a four period crossover study with all subjects receiving the four different preparations in a random order. The study was partially blinded in that the drugs were recognisably different but the subjects were not aware of which was which. Of the two principal investigators one (RPW) was blinded to the drugs. There was a wash out period of at least six days between studies.On each study day subjects arrived at 1700 on the investigation unit having fasted for six hours. Bipolar glass pH electrodes (Ingold M440) were calibrated in standard buffer solutions of pH 7.00 and 4.01 and calibration was verified at pH 1.69. These electrodes were passed by the nasogastric route. A drop in pH to less than 2 was taken as evidence of the tip of the probe having entered the stomach, and the electrode was advanced a further 8 cm from this point. At 1830 a standard meal was given, which consisted of a supermarket ready meal of cottage pie, peas, and carrots, followed by chocolate coated ice cream and two chocolate mints to give a total of 700 kcal, provided by 22 g protein, 70 g carbohydrate, and 37 g fat, accompanied by 250 ml mineral water.

show abstract