Effects of low-intensity aerobic training on the high-density lipoprotein cholesterol concentration in healthy elderly subjects

Sunami, Yoshiyuki; Motoyama, Mitsugi; Kinoshita, F; Mizooka, Y.; Sueta, Kazuyo; Matsunaga, Akira; Sasaki, Jun; Tanaka, Hiroaki; Shindo, Munehiro

doi:10.1016/s0026-0495(99)90194-4

Cited by 110 publications

(82 citation statements)

References 41 publications

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“…Studies included-Of the 3750 citations reviewed, 21 met our inclusion criteria [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]39,40]. However, we were unable to include two studies because of the inability to retrieve necessary data for HDL 2 -C [39,40].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…However, we were unable to include two studies because of the inability to retrieve necessary data for HDL 2 -C [39,40]. Thus, our percent loss that met our inclusion criteria was approximately 9%, leaving us with a total of 19 studies for analysis [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. A general description of the included studies is shown in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…while another two each were conducted in either Finland [11,13], Japan [14,16], or Switzerland [9,17]. The remaining six studies were conducted in either Israel [12], New Zealand [18], Portugal [19], Scotland [5], Sweden [20], or the United Kingdom [4].…”

Section: Country Of Origin-seven Studies Were Conducted In the Unitedmentioning

confidence: 99%

“…studies in which there were dropouts, the majority (88%) used an analysis-by-protocol approach to analyze their data [4][5][6][7][8]10,[13][14][15][16][18][19][20][21][22]. A total of 39 groups (20 exercise, 19 control) representing 984 subjects (516 exercise, 468 control) and 20 HDL 2 -C outcomes were available for pooling.…”

Section: Study Design-formentioning

confidence: 99%

“…However, the results of previous randomized controlled trials dealing with the effects of aerobic exercise on HDL 2 -C have led to less than overwhelming results [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], with only 30% of HDL 2 -C outcomes reported as statistically significant. While this may lead one to question the utility of aerobic exercise for increasing HDL 2 -C in adults, such a conclusion would be based on the vote-counting approach (percentage of statistically significant results), a procedure that has been shown to be less accurate than the more quantitative meta-analytic approach [23].…”

Section: Introductionmentioning

confidence: 99%

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley

2006

Atherosclerosis

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Purpose-Use the meta-analytic approach to examine the effects of aerobic exercise on highdensity lipoprotein two cholesterol (HDL 2 -C) in adults.Study sources-(1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list.Study selection-(1) Randomized controlled trials; (2) aerobic exercise ≥8 weeks; (3) adults ≥18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL 2 -C in the fasting state.Data abstraction-All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results-Nineteen randomized controlled trials representing 20 HDL 2 -C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL 2 -C (X̄ ± S.E.M., 2.6±0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL 2 -C were independent of decreases in body weight, body mass index (kg/m 2 ), and percent body fat.Conclusion-Aerobic exercise increases HDL 2 -C in adults.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Country Of Origin-seven Studies Were Conducted In the Unitedmentioning

confidence: 99%

Section: Study Design-formentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley

2006

Atherosclerosis

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Effect of Aerobic Exercise Training on Serum Levels of High-Density Lipoprotein Cholesterol

Kodama

Tanaka²,

Saito³

et al. 2007

Arch Intern Med

523

291

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Background: Aerobic exercise is believed to reduce the risk of cardiovascular disease partially through increasing serum levels of high-density lipoprotein cholesterol (HDL-C). However, this effect varies considerably among exercise intervention studies. Methods: Electronic database searches of MEDLINE (1966-2005) for randomized controlled trials that examined the effect of exercise training on HDL-C level. Results: Twenty-five articles were included. Mean net change in HDL-C level was statistically significant but modest (2.53 mg/dL [0.065 mmol/L]; PϽ.001). Minimal weekly exercise volume for increasing HDL-C level was estimated to be 900 kcal of energy expenditure per week or 120 minutes of exercise per week. Univariate regression analysis indicated that every 10-minute prolongation of exercise per session was associated with an approximately 1.4-mg/dL (0.036-mmol/L) increase in HDL-C level. In contrast, there was no significant asso

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High-density lipoprotein subfractions in normolipidemic individuals without clinical atherosclerosis lipoprotein subfractions in an adult population

Sodré

Castanho

Castilho

et al. 2006

J. Clin. Lab. Anal.

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This study evaluated the serum concentrations of lipids, lipoproteins, apolipoproteins, and high-density lipoprotein (HDL) subfractions in Brazilian adults. We analyzed the distribution of lipids in HDL2 and HDL3 in a normolipidemic population without evidence of established cardiovascular disease (CVD). A total of 93 males and 92 females, healthy and normolipidemic, volunteered to be submitted to a clinical examination, a blood collection, and to answer a questionnaire aimed at determining signs and symptoms of atherosclerotic disease. Their fasting plasma lipid, lipoproteins, apolipoproteins, and the cholesterol and triglyceride concentrations in HDL2 and HDL3, isolated by microultracentrifugation, were determined by enzymatic-colorimetric methods. The interpercentile intervals (2.5-97.5) for the population were established as being 5-18 mg/dL in men and 4-28 mg/dL in women for HDL2 cholesterol (HDL2chol) and 1-57 mg/dL in men and 2-61 mg/dL in women for HDL3 cholesterol (HDL3chol). HDL2 triglyceride levels (HDL2Tg) in men were 1-26 mg/dL and in women 2-28 mg/dL; moreover, the HDL3 triglyceride (HDL3Tg) intervals were established as 4-46 mg/dL for both sexes. The determination of reference ranges for lipids in HDL subfractions in populations without clinical atherosclerosis, is an useful tool for metabolic, diagnostic, and therapeutic approaches. We determined the intervals for HDL2chol, HDL3chol, HDL2Tg, and HDL3Tg. There were variations with sex and/or age for HDL2chol, HDL3chol, and HDL2Tg in the studied population.

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Effects of low-intensity aerobic training on the high-density lipoprotein cholesterol concentration in healthy elderly subjects

Cited by 110 publications

References 41 publications

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Effect of Aerobic Exercise Training on Serum Levels of High-Density Lipoprotein Cholesterol

High-density lipoprotein subfractions in normolipidemic individuals without clinical atherosclerosis lipoprotein subfractions in an adult population

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