Effects of Low-Intensity Pulsed Ultrasound on Healing of Mandibular Fractures: An Experimental Study in Rabbits

Özgür, Erdoğan; Esen, Emin; Üstün, Yakup; Kürkçü, Mehmet; Akova, Tolga; Gönlüşen, Gülfiliz; Uysal, Hakan; Çevlik, Filiz

doi:10.1016/j.joms.2005.10.027

Cited by 53 publications

(44 citation statements)

References 38 publications

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“…Indeed, in vivo studies and randomized, controlled clinical trials clearly proved a significant increase in the rate of bone healing and restoration of biomechanical function following US treatments [11]. Enhanced bone healing in tibial [10], radial [11], scaphoid [38] and mandibular [39] fractures has been observed. Studies carried out on animal models of ligament, tendon and cartilage injury demonstrated the beneficial effects of US stimulation in wound repair of tissues other than bone [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor

Monici¹,

Bernabei²,

Basile³

et al. 2007

Acta Astronautica

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Section: Discussionmentioning

confidence: 99%

Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor

Monici¹,

Bernabei²,

Basile³

et al. 2007

Acta Astronautica

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“…7,8 Erdogan et al found considerable contributions of LIPU (1.5 MHz) to bone healing in mandibular fractures. 9 These previously reported studies used 1.5 MHz ultrasound in the maxillofacial area. 1,[6][7][8][9] Although some compared the bone healing process based on weeks post application, 1,6,8 the effect of different frequencies has not been evaluated in this region.…”

mentioning

confidence: 99%

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Bronoosh

Tanideh

Noorafshan

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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“…Ërdogan et al 36) irradiated the osteotomized area of rabbit mandible with LIPUS and reported an increase in the thickness in the callus that formed and reduced trabecular separation. In this study, expression of OC was observed in the exterior of new bone in both R1CG and P6CG.…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Intensity Pulsed Ultrasound on Bone-Healing Process in Murine Low-Turnover Osteoporosis Model

Yoshida

Sasaki

Yoshinari

et al. 2013

J. Hard Tissue Biology.

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The effects of postmenopausal osteoporosis for bone defect healing processes have already been reported, but not for senile osteoporosis caused by low-turnover metabolism. Low-Intensity-Pulsed Ultrasound (LIPUS) is known to promote bone defect healing in high-turnover osteoporosis an animal model. The aim of this study was to investigate the effect of LIPUS on the bone-healing process in a low-turnover osteoporosis model using the Senescence-Accelerated Mouse Prone 6 (SAMP6) strain of mice. Twenty-week-old SAMP6 and Senescence-Accelerated Mouse Resistant (SAMR1) mice were used as senile osteoporosis and normal aging models, respectively. Bone defects (diameter, 0.9 mm) were created in the both SAMP6 and SAMR1 femurs. At 7days after surgery, the LIPUS irradiation groups of SAMR1 (R1LG) and SAMP6 (P6LG) were exposed to LIPUS (1.0 MHz, 320 mW, 15 min/day) for 6 days. The non-irradiation groups of SAMR1 (R1CG) and SAMP6 (P6CG) were used as controls. All groups were sacrificed at 14 days after creation of bone defects. Radiological analysis, histological evaluation and immunohistochemical staining for osteocalcin (OC) were performed. From the radiological evaluation, the new bone of defected area in SAMR1 group showed cortical bone-like structure, but that in the SAMP6 group showed trabecular bone-like structures. The increase in bone area in P6LG was greater than that in P6CG according to chronological change analysis using X-ray micro-CT (p < 0.01). Histological analysis revealed outward new bone formation originating in the periosteum in P6LG. Positive reaction for OC was localized on the surface of new bone in P6CG, whereas that in P6LG was observed over the whole region of new bone, from the outer to the bone marrow side.These results showed that LIPUS accelerates healing on low-turnover osteoporosis by promoting bone formation from periosteum and supplementing reduced bone formation from bone marrow.

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Effects of Low-Intensity Pulsed Ultrasound on Healing of Mandibular Fractures: An Experimental Study in Rabbits

Cited by 53 publications

References 38 publications

Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor

Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Effect of Low-Intensity Pulsed Ultrasound on Bone-Healing Process in Murine Low-Turnover Osteoporosis Model

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