Effects of low-level laser therapy on osteoblastic bone formation and relapse in an experimental rapid maxillary expansion model

Aras, Mutan Hamdi; Erkılıç, Suna; Demi̇r, Tuncer; Demirkol, Mehmet; Kaplan, Davut Sinan; Yolcu, Ümit

doi:10.4103/1119-3077.154218

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…Although the biological mechanisms of low-level laser irradiation or low-level laser therapy/treatment (LLLT) have not been fully revealed, LLLT is a successfully and widely used non-pharmacological method for bone regeneration in experimental in vivo and in vitro models [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Current research suggests that LLLT stimulates the proliferation and differentiation of various cell types and promotes the repair process in vivo and in vitro : a wavelength of 600–904 nm and an output power of 1–500 mW; activation of ERK1/ERK2 and a phosphatidylinositol 3-kinase (PI3K) pathway; the increase of reactive oxygen species (ROS) and ATP/cyclic AMP; the absorption of light by a photoreceptor and the photoactivation of enzymes in the mitochondria; etc.…”

Section: Introductionmentioning

confidence: 99%

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Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation

Yoo

Lee

Park

et al. 2015

IJMS

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Low-level laser therapy/treatment (LLLT) using a minimally invasive laser needle system (MILNS) might enhance bone formation and suppress bone resorption. In this study, the use of 405 nm LLLT led to decreases in bone volume and bone mineral density (BMD) of tibial trabecular bone in wild-type (WT) and Per2 knockout (KO) mice. Bone volume and bone mineral density of tibial trabecular bone was decreased by 405 nm LLLT in Per2 KO compared to WT mice at two and four weeks. To determine the reduction in tibial bone, mRNA expressions of alkaline phosphatase (ALP) and Per2 were investigated at four weeks after 405 nm laser stimulation using MILNS. ALP gene expression was significantly reduced in the LLLT-stimulated right tibial bone of WT and Per2 KO mice compared to the non-irradiated left tibia (p < 0.001). Per2 mRNA expression in WT mice was significantly reduced in the LLLT-stimulated right tibial bone compared to the non-irradiated left tibia (p < 0.001). To identify the decrease in tibial bone mediated by the Per2 gene, levels of runt-related transcription factor 2 (Runx2) and ALP mRNAs were determined in non-irradiated WT and Per2 KO mice. These results demonstrated significant downregulation of Runx2 and ALP mRNA levels in Per2 KO mice (p < 0.001). Therefore, the reduction in tibial trabecular bone resulting from 405 nm LLLT using MILNS might be associated with Per2 gene expression.

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Section: Introductionmentioning

confidence: 99%

“…[ 1 , 2 ]. With respect to bone, LLLT has been shown to modulate inflammatory processes and bone repair [ 3 , 4 , 5 ], accelerate osteoblast proliferation and bone formation [ 6 , 7 , 8 , 9 , 10 ], and enhance bone healing [ 1 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation

Yoo

Lee

Park

et al. 2015

IJMS

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“…They concluded that histologically, LLLT stimulated bone formation. 19 The effects of LLLT can also be seen on human cells, Khadra et al 2005 studied the effects of LLLT on attachment, proliferation and differentiation of human osteoblast-like cells cultured on titanium implant material using an 830nm Ga-Al-As diode laser. (Rønvig Dental AS, Denmark) Each culture dish was irradiated with 84mW at a dosage of 1.5 or 3J/cm 2 .…”

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confidence: 99%

Clinical and experimental knowledge of photobiomodulation in accelerated orthodontics: a review

Santana

Vega²,

Vázquez³

et al. 2021

Rev Estomatol

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In recent years, there has been an increasing interest in finding a noninvasive method to induce the acceleration of dental movement, methods such as low intensity vibrations, pulsed electromagnetic fields, and low-level laser therapy (LLLT). There have been multiple studies on the efficacy of LLLT in animal models, in vitro and in patients without conclusive results. Objective: Evaluate the state of the art on the use of LLLT to increase the rate of the orthodontic tooth movement to create a concise reference guide of the different laser and protocols available. Materials and Methods: We searched online databases for articles with the keywords LLLT, LLLI, OTM, photobiomodulation. Results: We found conflicting information as to the efficacy of LLLT to accelerate OTM. There is no consensus in the way the irradiation should be performed. Conclusions: The lack of a standardized irradiation protocol makes it hard to compare conflicting results, even in cases where the laser have the same technical specifications.

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The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Effects of low-level laser therapy on osteoblastic bone formation and relapse in an experimental rapid maxillary expansion model

Abstract: Histologically, LLLT stimulated bone formation, as revealed by analysis after the retention period. LLLT during expansion may accelerate bone healing.

Cited by 11 publications

References 17 publications

Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation

Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation

Clinical and experimental knowledge of photobiomodulation in accelerated orthodontics: a review

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

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