Effects of <b><i>Aloe</i></b> Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial

Abstract

Background/Aims: Our previous study confirmed that Aloe sterol stimulates collagen and hyaluronic acid production in human dermal fibroblasts. This study aims to investigate whether Aloe sterol intake affects skin conditions. Methods: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin elasticity, hydration, and the collagen score in 64 healthy women (age range 30-59 years; average 44.3 years) who were randomly assigned to receive either a placebo or an Aloe sterol-supplemented yogurt. Skin parameters were measured and ultrasound analysis of the forearm was performed. Results: ANCOVA revealed statistical differences in skin moisture, transepidermal water loss, skin elasticity, and collagen score between the Aloe sterol and placebo groups. The gross elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores of the Aloe sterol group significantly increased with time. In addition, skin fatigue area F3, which is known to decrease with age and fatigue, also increased with Aloe sterol intake. Ultrasound echogenicity revealed that the collagen content in the dermis increased with Aloe sterol intake. Conclusion: The results suggest that continued Aloe sterol ingestion contributes to maintaining healthy skin.

<em>Aloe</em> sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial

“…Our recent clinical study suggested that the Aloe sterol intake induced a significant increase in the skin hydration of Japanese women’s skin that was protected from sunlight by clothing 15. In a basic research report, we suggested that the Aloe sterols prevented significant UVB irradiation-induced decreases in skin hydration, elasticity, and hyaluronic acid synthase 2 (Has2) in hairless mice 14.…”

“…Our previous study revealed that the levels of skin moisture, skin elasticity, and collagen scores in the Aloe sterol group were higher than those of the placebo groups 15. Furthermore, ultrasound echogenicity revealed that Aloe sterol intake increased the amount of collagen in the dermis.…”

Nutricosmetics: A brief overview

“…Aloe gel supplementation improves collagen production and reduces collagen‐degrading MMP‐1 gene expression, enhancing wrinkles and elasticity in photoaged human skin, with no dose‐response relationship (Cho et al, ). Aloe sterol ingestion contributes to collagen and HA production in human dermal fibroblasts ameliorating skin moisture, trans‐epidermal water loss and, skin elasticity (Tanaka et al, ).…”

“…Barley and soy seeds [Colour figure can be viewed at wileyonlinelibrary.com] Secondary metabolites FIGURE 7 Horsetail (Equisetum arvense L.) [Colour figure can be viewed at wileyonlinelibrary.com] 5.7.3 | Aloe vera (Figure 8)Aloe gel supplementation improves collagen production and reduces collagen-degrading MMP-1 gene expression, enhancing wrinkles and elasticity in photoaged human skin, with no dose-response relationship(Cho et al, 2009). Aloe sterol ingestion contributes to collagen and HA production in human dermal fibroblasts ameliorating skin moisture, trans-epidermal water loss and, skin elasticity(Tanaka et al, 2016).5.7.4 | Pine bark (Pinus pinaster; Figure 9)Pine bark extract supplements contain mainly flavonoids (catechins and procyanidins) and phenolic acids (caffeic, ferulic, and p-hydroxybenzoic acids) and are able to have photoprotective effect and to increase the hydration and the elasticity of the skin. Their biological effects are related to the increase of HA synthase, to the RNA expression, and to gene expression involved in collagen de novo synthesis (Pérez-Sánchez,Barrajón-Catalán, Herranz-López, & Micol, 2018).…”

Epigenetic Roles of Microbiota and Aloe vera in Health and Disease

“…Furthermore, the same research group evaluated the effects of oral aloe sterol supplementation on skin elasticity, hydration, and the collagen score in 64 healthy Japanese women aged 30-59 years. It was concluded that continued aloe sterol ingestion contributes to maintain healthy skin and prevents the skin photo-aging [47] . Saito et al [48] investigated the effects of oral aloe vera gel powder (AVGP) containing aloe sterols on skin elasticity and the extracellular matrix in UVB-irradiated hairless mice.…”