Effects of luteolin on learning acquisition in rats: Involvement of the central cholinergic system

Tsai, Fan-Shiu; Peng, Wen-Huang; Wang, Wen-Hsin; Wu, Chi‐Rei; Hsieh, Chih-Chang; Lin, Yung-Hsiang; Feng, Ifrim-Chen; Hsieh, Μing-Tsuen

doi:10.1016/j.lfs.2007.01.055

Cited by 46 publications

(32 citation statements)

References 39 publications

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“…Luteolin, belongs to the fl avonoids, possesses phytoestrogen mimicking actions and has been shown to have a positive effect on the cognitive function in females (Lee et al, 2005). Our previous study found that luteolin attenuated the defi cits of passive avoidance performance induced by SCOP (Tsai et al, 2007). Similarly, the gonadal hormone 17-estradiol is known to affect the organization of the developing brain (Arai et al, 1996) and also to improve memory and to offer protection against Alzheimer's disease (van Duijn, 1999) as well as other forms of neuronal degeneration (Linford and Dorsa, 2002).…”

Section: Discussionmentioning

confidence: 97%

“…In modern pharmacological studies, luteolin possesses a high DNA protective effect in the presence of H 2 O 2 (Romanova et al, 2001), antiinfl ammatory, antioxidant, anti-AP1 activation (Hirano et al, 2006) and phytoestrogen-like activities (Dall'Acqua and Innocenti, 2004), and is a free radical scavenger (Brown and Rice-Evans, 1998;Sadzuka et al, 1997). A previous study found that luteolin attenuates SCOP-induced amnesia (Tsai et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effect of luteolin on amyloid β protein (25–35)‐induced toxicity in cultured rat cortical neurons

Cheng

Hsieh

Tsai

et al. 2010

Phytotherapy Research

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The present study was carried out to investigate the neuroprotective effect of luteolin on amyloid beta (Abeta) (25-35)-induced neurotoxicity using cultured rat cortical neurons. After exposure of primary cultures of rat cortical cells to 10 muM Abeta (25-35) for 48 h, cortical cell cultures exhibited marked apoptotic death. Pretreatment with luteolin (1, 10 microM) significantly protected cortical cell cultures against Abeta (25-35)-induced toxicity. Luteolin (1, 10 microM) showed a concentration-dependent inhibition on 10 muM Abeta (25-35)-induced apoptotic neuronal death, as assessed by MTT assay. Furthermore, luteolin reduced apoptotic characteristics by DAPI staining. For Western blot analysis, the results showed that the protective effect of luteolin on Abeta (25-35)-induced neurotoxicity was mediated by preventing of ERK-p, JNK, JNK-p, P38-p and caspase 3 activations in rat primary cortical cultures. Taken together, the results suggest that luteolin prevents Abeta (25-35)-induced apoptotic neuronal death through inhibiting the protein level of JNK, ERK and p38 MAP kinases and caspase 3 activations.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of luteolin on amyloid β protein (25–35)‐induced toxicity in cultured rat cortical neurons

Cheng

Hsieh

Tsai

et al. 2010

Phytotherapy Research

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“…Natural products are famous for their anti-oxidant, anti-inflammatory and protective effects on multiple organs [8,9]. One of them is Luteolin (3,4,5,7-tetra-hydroxylflavone) (LUT) that is found in celery, green pepper, perilla leaf and seed, chamomile tea, and Lonicera japonica [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of luteolin on intra peritoneal adhesion bands in rat

Hashemzaei¹,

Badrooze²,

Tabrizian³

et al. 2016

J. Fundam and Appl Sci.

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Intraperitoneal adhesion is consequences of surgery in the abdomen and result in infertility, intestinal obstruction and pelvic pain. Luteolin (LUT) is a natural product that has antiinflammatory, anti-oxidant, anti-angiogenic effects and its effects were evaluated as anti-adhesive in animal model. 30 male rats assigned in to 5 groups (6 animals in each group) of LUT 10, 25 and 50 mg/kg and normal saline as a control group and intact animals. Animal anesthetized and peritoneal injury was conducted and seven days following to surgery, they scarified. Microscopic, macroscopic, lipid peroxidation changes and TNF-α plasma concentration were evaluated. LUT reduced microscopic and macroscopic injury and lipid peroxidation significantly. Plasma concentrations of TNF-α didn't show any changes. LUT reduces lipid peroxidation, adhesion band formation in microscopic and macroscopic scale but no change in the serum levels of TNFalpha.

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“…Luteolin is a naturally occurring yellow pigment or flavone found in a variety of plants, particularly vegetables such as celery, green pepper, perilla leaf, and so on (Tsai et al, 2007;Yoo et al, 2009;Lv et al, 2009). Luteolin is a potent antioxidant (Lee et al, 1995) and has been shown to possess antiplatelet aggregation (Lu et al, 2001), anticancer, and anti-inflammatory properties (Kim et al, 2005;Phosrithong and Ungwitayatorn, 2009).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and anti-inflammatory activities of rare earth metal complexes of luteolin

et al. 2009

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Twelve as yet, unreported complexes of luteolin were synthesized with various rare earth ions through refluxing in ethanol. The characterization of these complexes by elemental analysis, infrared spectra, and differential scanning calorimeter demonstrated that luteolin coordinated the various rare earth ions in a similar manner. Experiments designed to study the anti-inflammatory activities of these rare earth-luteolin complexes indicated that they had a significant inhibitory effect on xyleneinduced ear edema in mice. Five complexes containing

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Effects of luteolin on learning acquisition in rats: Involvement of the central cholinergic system

Cited by 46 publications

References 39 publications

Neuroprotective effect of luteolin on amyloid β protein (25–35)‐induced toxicity in cultured rat cortical neurons

Neuroprotective effect of luteolin on amyloid β protein (25–35)‐induced toxicity in cultured rat cortical neurons

Effects of luteolin on intra peritoneal adhesion bands in rat

Synthesis, characterization, and anti-inflammatory activities of rare earth metal complexes of luteolin

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