Effects of luteolin on sepsis: A comprehensive systematic review

Vajdi, Mahdi; Karimi, Arash; Karimi, Mozhdeh; Farhangi, Mahdieh Abbasalizad; Askari, Gholamreza

doi:10.1016/j.phymed.2023.154734

Cited by 12 publications

(5 citation statements)

References 93 publications

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“…Previous studies reported that both luteolin and kaempferol downregulate MAPK/NF-κB-mediated inflammation [ 36 , 37 ]. Luteolin has been reported to attenuate LPS-induced organ damage and myocardial injury [ 38 , 39 ]. In addition, kaempferol has been reported to potentially inhibit oxidative tissue injury and pulmonary inflammatory response [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice

Choi

Kim

et al. 2023

Pharmaceutics

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The interest in bioconversion through fermentation of sprouts produced in smart farms is increasing due to their potential health benefits. Codonopsis lanceolata (CL) is reported to alleviate inflammatory conditions, but much research is still needed to determine which types and parts of CL are most effective. This study investigated the anti-inflammatory effects of a fermented extract of CL sprouts’ aerial part (F-CSA) against LPS-stimulated RAW 264.7 macrophages and mice. In the screening test, F-CSA showed the most substantial anti-inflammatory effect among several samples, containing the highest total flavonoids, tannins, and polyphenols. UPLC-ESI-Q/TOF-MS and HPLC analysis revealed that F-CSA had the highest amount of luteolin among all the CL samples analyzed. F-CSA reduced the release of inflammatory cytokines and mediators such as NO and PGE2 by inhibiting the expression levels of iNOS and COX-2 in LPS-stimulated macrophages. Further, we found that the anti-inflammatory effects of F-CSA were mediated by inhibiting the JNK/NF-κB signaling pathway. Moreover, F-CSA improved survival rates and reduced plasma levels of NO and IL-6 in CD1 mice stimulated with LPS. These findings suggest that F-CSA, which contains luteolin, can alleviate inflammation in LPS-induced RAW 264.7 cells and a CD1 mouse model by inhibiting the JNK/NF-κB signaling pathways.

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Section: Resultsmentioning

confidence: 99%

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice

Choi

Kim

et al. 2023

Pharmaceutics

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“…[13] It has a benefi cial eff ect on sepsis through multiple pathways, such as alleviating oxidative stress, infl uencing the initiation of inflammatory pathways, reducing the expression of inflammatory factors, and modulating the immune response. [14] Kaempferol is a natural polyphenol small molecule that can inhibit oxidative stress injury and inflammation in the livers of septic rats. [15] Kaempferol can combat sepsis by alleviating the inflammatory response induced by lipopolysaccharides through the regulation of the sphingosine kinase type 1/sphingosine 1-phosphate (SphK1/S1P) signaling pathway, thus stabilizing the endothelial barrier.…”

Section: Discussionmentioning

confidence: 99%

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

Zhou,

Fan,

et al. 2024

World Journal of Emergency Medicine

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BACKGROUND: Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten the intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated with sepsis, but the molecular mechanisms have not been elucidated. This study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology approach. METHODS:The active ingredients and targets of XBJ were retrieved from the ETCM database. Potential targets related to PLA and sepsis were retrieved from the GeneCards, PharmGKB, DisGeNet, Online Mendelian Inheritance in Man (OMIM), Therapeutic Targets Database (TTD), and DrugBank databases. The targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment targets. Protein-protein interaction networks were analyzed using the STRING database. Potential treatment targets were imported into the Metascape platform for Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Molecular docking was performed to validate the interactions between active ingredients and core targets.RESULTS: XBJ was found to have 54 potential treatment targets for PLA complicated with sepsis. Interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF) were identifi ed as core targets. KEGG enrichment analysis revealed important pathways, including the interleukin-17 (IL-17) signaling pathway, the TNF signaling pathway, the nuclear factor-kappa B (NF-κB) signaling pathway, and the Toll-like receptor (TLR) signaling pathway. Molecular docking experiments indicated stable binding between XBJ active ingredients and core targets.CONCLUSION: XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways, such as the TNF, and TLR pathways, and TNF.

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“…[34] More and more studies have shown that luteolin can be used to treat gouty arthritis, diabetes, tumors, and cardiovascular and cerebrovascular diseases. [35][36][37][38][39] Researchers found that luteolin can reduce joint synovial hyperplasia, cartilage, and bone erosion in GA rats. [40] Luteolin reduces the expression of MyD88 by regulating TLR4 receptors, thereby inhibiting the expression of NF-κB-related proteins, reducing the release of related inflammatory factors, and alleviating the inflammatory cascade, thereby protecting joints.…”

Section: Luteolinmentioning

confidence: 99%

Exploring effect of herbal monomers in treating gouty arthritis based on nuclear factor-kappa B signaling: A review

Guo,

Ye,

Tang

et al. 2024

Medicine

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Gouty arthritis (GA) is an inflammatory disease caused by disorders of the purine metabolism. Although increasing number of drugs have been used to treat GA with the deepening of relevant research, GA still cannot be cured by simple drug therapy. The nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in the pathogenesis of GA. A considerable number of Chinese herbal medicines have emerged as new drugs for the treatment of GA. This article collected relevant research on traditional Chinese medicine monomers in the treatment of GA using NF-κB, GA, etc. as keywords; and conducted a systematic search of relevant published articles using the PubMed database. In this study, we analyzed the therapeutic effects of traditional Chinese medicine monomers on GA in the existing literature through in vivo and in vitro experiments using animal and cell models. Based on this review, we believe that traditional Chinese medicine monomers that can treat GA through the NF-κB signaling pathway are potential new drug development targets. This study provides research ideas for the development and application of new drugs for GA.

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Effects of luteolin on sepsis: A comprehensive systematic review

Cited by 12 publications

References 93 publications

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice

Fermented Sprouts of Codonopsis lanceolata Suppress LPS-Induced Inflammatory Responses by Inhibiting NF-κB Signaling Pathway in RAW 264.7 Macrophages and CD1 Mice

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

Exploring effect of herbal monomers in treating gouty arthritis based on nuclear factor-kappa B signaling: A review

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